Aspn ELISA Kit for Mouse(Mus musculus) | EIAab.comAspn ELISA Kit for Mouse(Mus musculus)

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Aspn (Gene name),

Asporin (Protein name ), ASPN_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aspn;

Protein name:

Asporin;

Alternative:

Periodontal ligament-associated protein 1(PLAP-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with type I collagen. DCN can inhibit collagen binding (By similarity). Interacts with TGFB1, TGFB2 and TGFB3. DCN, BGN, and FMOD inhibit binding to TGFB1. Interacts with BMP2. Interacts in vitro with type II collagen.

Function:

Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to the BMP receptor-IB (BMPR-IB), resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

373

Sequence:

50:

100:

150:

200:

250:

300:

350:

373:

EIQPATFRCV | LGRMSVQLGN | VGK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:66695

UniGene:

Mm.383216

String:

Q99MQ4

SMR:

Q99MQ4

Pfam:

PF00560

Pfam:

PF01462

Uniprot:

Q99MQ4

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ELISA Kit for Mouse Asporin

Cat.:

E1043b

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96T

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ELISA Kit for Mouse Asporin

Cat.:

E1043m

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96T

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ELISA Kit for Mouse Asporin

Cat.:

E1043h

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96T

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CLIA Kit for Mouse Asporin

Cat.:

U1043h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse Asporin

Cat.:

U1043b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Asporin

Cat.:

U1043m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Asporin

Cat.:

P1043Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Asporin

Cat.:

P1043Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Asporin

Monoclonal Antibody for Mouse Asporin

Protein for Mouse Asporin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan."
Lorenzo P. , Aspberg A. , Oennerfjord P. , Bayliss M.T. , Neame P.J. , Heinegaard D.
J. Biol. Chem.276:12201-12211(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6 X 129/SvJ.
tissue: Aorta.
2.

"Expression pattern and gene characterization of asporin. A newly discovered member of the leucine-rich repeat protein family."
Henry S.P. , Takanosu M. , Boyd T.C. , Mayne P.M. , Eberspaecher H. , Zhou W. , de Crombrugghe B. , Hoeoek M. , Mayne R.
J. Biol. Chem.276:12212-12221(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Skin.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Mammary gland.
5.

"PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization."
Yamada S. , Tomoeda M. , Ozawa Y. , Yoneda S. , Terashima Y. , Ikezawa K. , Ikegawa S. , Saito M. , Toyosawa S. , Murakami S.
J. Biol. Chem.282:23070-23080(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH BMP2
6.

"Mechanisms for asporin function and regulation in articular cartilage."
Nakajima M. , Kizawa H. , Saitoh M. , Kou I. , Miyazono K. , Ikegawa S.
J. Biol. Chem.282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TGFB1; TGFB2 AND TGFB3
7.

"Expression and regulation of the osteoarthritis-associated protein asporin."
Kou I. , Nakajima M. , Ikegawa S.
J. Biol. Chem.282:32193-32199(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY TGFB1;TISSUE SPECIFICITY
8.

"PLAP-1/asporin inhibits activation of BMP receptor via its leucine-rich repeat motif."
Tomoeda M. , Yamada S. , Shirai H. , Ozawa Y. , Yanagita M. , Murakami S.
Biochem. Biophys. Res. Commun.371:191-196(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ARG-170; GLU-194 AND ARG-219;DOMAIN LRR
9.

"Binding characteristics of the osteoarthritis-associated protein asporin."
Kou I. , Nakajima M. , Ikegawa S.
J. Bone Miner. Metab.28:395-402(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TGFB1 AND TYPE II COLLAGEN

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