Gene name:
ATP1A2 (KIAA0778) ;
Protein name:
Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) ;
Alternative:
Sodium pump subunit alpha-2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Composed of three subunits: alpha (catalytic), beta and gamma.
Function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
Subcellular Location:
Membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGRGAGREYS | PAATTAENGG | GKKKQKEKEL | DELKKEVAMD | DHKLSLDELG |
100:
RKYQVDLSKG | LTNQRAQDVL | ARDGPNALTP | PPTTPEWVKF | CRQLFGGFSI |
150:
LLWIGAILCF | LAYGIQAAME | DEPSNDNLYL | GVVLAAVVIV | TGCFSYYQEA |
200:
KSSKIMDSFK | NMVPQQALVI | REGEKMQINA | EEVVVGDLVE | VKGGDRVPAD |
250:
LRIISSHGCK | VDNSSLTGES | EPQTRSPEFT | HENPLETRNI | CFFSTNCVEG |
300:
TARGIVIATG | DRTVMGRIAT | LASGLEVGRT | PIAMEIEHFI | QLITGVAVFL |
350:
GVSFFVLSLI | LGYSWLEAVI | FLIGIIVANV | PEGLLATVTV | CLTLTAKRMA |
400:
RKNCLVKNLE | AVETLGSTST | ICSDKTGTLT | QNRMTVAHMW | FDNQIHEADT |
450:
TEDQSGATFD | KRSPTWTALS | RIAGLCNRAV | FKAGQENISV | SKRDTAGDAS |
500:
ESALLKCIEL | SCGSVRKMRD | RNPKVAEIPF | NSTNKYQLSI | HEREDSPQSH |
550:
VLVMKGAPER | ILDRCSTILV | QGKEIPLDKE | MQDAFQNAYM | ELGGLGERVL |
600:
GFCQLNLPSG | KFPRGFKFDT | DELNFPTEKL | CFVGLMSMID | PPRAAVPDAV |
650:
GKCRSAGIKV | IMVTGDHPIT | AKAIAKGVGI | ISEGNETVED | IAARLNIPMS |
700:
QVNPREAKAC | VVHGSDLKDM | TSEQLDEILK | NHTEIVFART | SPQQKLIIVE |
750:
GCQRQGAIVA | VTGDGVNDSP | ALKKADIGIA | MGISGSDVSK | QAADMILLDD |
800:
NFASIVTGVE | EGRLIFDNLK | KSIAYTLTSN | IPEITPFLLF | IIANIPLPLG |
850:
TVTILCIDLG | TDMVPAISLA | YEAAESDIMK | RQPRNSQTDK | LVNERLISMA |
900:
YGQIGMIQAL | GGFFTYFVIL | AENGFLPSRL | LGIRLDWDDR | TMNDLEDSYG |
950:
QEWTYEQRKV | VEFTCHTAFF | ASIVVVQWAD | LIICKTRRNS | VFQQGMKNKI |
1000:
LIFGLLEETA | LAAFLSYCPG | MGVALRMYPL | KVTWWFCAFP | YSLLIFIYDE |
1020:
VRKLILRRYP | GGWVEKETYY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Chicken
Human
Rat
Pig
ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
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Nature441:315-321(2006)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Ovary .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 211-249
tissue :
Leukocyte .
7.
"The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit."
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FEBS Lett.217:275-278(1987)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 251-442
tissue :
Brain .
tissue :
Placenta .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-4
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-570 AND SER-587;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
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"Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions."
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Ann. Neurol.54:360-366(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS FHM2 GLN-689 AND THR-731
12.
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Cited for : VARIANTS FHM2 PRO-764 AND ARG-887;CHARACTERIZATION OF VARIANTS FMH2 PRO-764 AND ARG-887
13.
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Cited for : VARIANT AHC1 ASN-378
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FHM2 ARG-715
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FHM2 TRP-1007
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FHM2 SER-874