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Index > Protein center > ATP1A2(Gene name) > Human
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  • ATP1A2 (Gene name),
  • Sodium/potassium-transporting ATPase subunit alpha-2 (Protein name ),  AT1A2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ATP1A2(KIAA0778);
    Protein name:
    Sodium/potassium-transporting ATPase subunit alpha-2(Na(+)/K(+) ATPase alpha-2 subunit);
    Alternative:
    Sodium pump subunit alpha-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Composed of three subunits: alpha (catalytic), beta and gamma.
    Function:
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
    Subcellular Location:
    Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1020
    Sequence:
    50:
    MGRGAGREYS | PAATTAENGG | GKKKQKEKEL | DELKKEVAMD | DHKLSLDELG | 
    100:
    RKYQVDLSKG | LTNQRAQDVL | ARDGPNALTP | PPTTPEWVKF | CRQLFGGFSI | 
    150:
    LLWIGAILCF | LAYGIQAAME | DEPSNDNLYL | GVVLAAVVIV | TGCFSYYQEA | 
    200:
    KSSKIMDSFK | NMVPQQALVI | REGEKMQINA | EEVVVGDLVE | VKGGDRVPAD | 
    250:
    LRIISSHGCK | VDNSSLTGES | EPQTRSPEFT | HENPLETRNI | CFFSTNCVEG | 
    300:
    TARGIVIATG | DRTVMGRIAT | LASGLEVGRT | PIAMEIEHFI | QLITGVAVFL | 
    350:
    GVSFFVLSLI | LGYSWLEAVI | FLIGIIVANV | PEGLLATVTV | CLTLTAKRMA | 
    400:
    RKNCLVKNLE | AVETLGSTST | ICSDKTGTLT | QNRMTVAHMW | FDNQIHEADT | 
    450:
    TEDQSGATFD | KRSPTWTALS | RIAGLCNRAV | FKAGQENISV | SKRDTAGDAS | 
    500:
    ESALLKCIEL | SCGSVRKMRD | RNPKVAEIPF | NSTNKYQLSI | HEREDSPQSH | 
    550:
    VLVMKGAPER | ILDRCSTILV | QGKEIPLDKE | MQDAFQNAYM | ELGGLGERVL | 
    600:
    GFCQLNLPSG | KFPRGFKFDT | DELNFPTEKL | CFVGLMSMID | PPRAAVPDAV | 
    650:
    GKCRSAGIKV | IMVTGDHPIT | AKAIAKGVGI | ISEGNETVED | IAARLNIPMS | 
    700:
    QVNPREAKAC | VVHGSDLKDM | TSEQLDEILK | NHTEIVFART | SPQQKLIIVE | 
    750:
    GCQRQGAIVA | VTGDGVNDSP | ALKKADIGIA | MGISGSDVSK | QAADMILLDD | 
    800:
    NFASIVTGVE | EGRLIFDNLK | KSIAYTLTSN | IPEITPFLLF | IIANIPLPLG | 
    850:
    TVTILCIDLG | TDMVPAISLA | YEAAESDIMK | RQPRNSQTDK | LVNERLISMA | 
    900:
    YGQIGMIQAL | GGFFTYFVIL | AENGFLPSRL | LGIRLDWDDR | TMNDLEDSYG | 
    950:
    QEWTYEQRKV | VEFTCHTAFF | ASIVVVQWAD | LIICKTRRNS | VFQQGMKNKI | 
    1000:
    LIFGLLEETA | LAAFLSYCPG | MGVALRMYPL | KVTWWFCAFP | YSLLIFIYDE | 
    1020:
    VRKLILRRYP | GGWVEKETYY | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-2 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-2 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-2 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-2 subunit

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    References
    1. 1.
      "Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms."
      Shull M.M. , Pugh D.G. , Lingrel J.B.
      J. Biol. Chem.264:17532-17543(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ovary.
    6. 6.
      "Multiple genes encode the human Na+,K+-ATPase catalytic subunit."
      Shull M.M. , Lingrel J.B.
      Proc. Natl. Acad. Sci. U.S.A.84:4039-4043(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-249
      tissue: Leukocyte.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 251-442
      tissue: Brain.
      tissue: Placenta.
    8. 8.
      "Family of human Na+,K+-ATPase genes. Structure of the putative regulatory region of the alpha+-gene."
      Sverdlov E.D. , Bessarab D.A. , Malyshev I.V. , Petrukhin K.E. , Smirnov Y.V. , Ushkaryov Y.A. , Monastyrskaya G.S. , Broude N.E. , Modyanov N.N.
      FEBS Lett.244:481-483(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-4
    9. 9.
      "Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle."
      Hundal H.S. , Maxwell D.L. , Ahmed A. , Darakhshan F. , Mitsumoto Y. , Klip A.
      Mol. Membr. Biol.11:255-262(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-570 AND SER-587;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions."
      Vanmolkot K.R.J. , Kors E.E. , Hottenga J.-J. , Terwindt G.M. , Haan J. , Hoefnagels W.A.J. , Black D.F. , Sandkuijl L.A. , Frants R.R. , Ferrari M.D. , van den Maagdenberg A.M.J.M.
      Ann. Neurol.54:360-366(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FHM2 GLN-689 AND THR-731
    12. 12.
      "Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2."
      De Fusco M. , Marconi R. , Silvestri L. , Atorino L. , Rampoldi L. , Morgante L. , Ballabio A. , Aridon P. , Casari G.
      Nat. Genet.33:192-196(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FHM2 PRO-764 AND ARG-887;CHARACTERIZATION OF VARIANTS FMH2 PRO-764 AND ARG-887
    13. 13.
      "Alternating hemiplegia of childhood or familial hemiplegic migraine? A novel ATP1A2 mutation."
      Swoboda K.J. , Kanavakis E. , Xaidara A. , Johnson J.E. , Leppert M.F. , Schlesinger-Massart M.B. , Ptacek L.J. , Silver K. , Youroukos S.
      Ann. Neurol.55:884-887(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHC1 ASN-378
    14. 14.
      "Prolonged sporadic hemiplegic migraine associated with a novel de novo missense ATP1A2 gene mutation."
      De Sanctis S. , Grieco G.S. , Breda L. , Casali C. , Nozzi M. , Del Torto M. , Chiarelli F. , Verrotti A.
      Headache51:447-450(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHM2 ARG-715
    15. 15.
      "Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy."
      Pisano T. , Spiller S. , Mei D. , Guerrini R. , Cianchetti C. , Friedrich T. , Pruna D.
      Cephalalgia33:1302-1310(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHM2 TRP-1007
    16. 16.
      "A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy."
      Costa C. , Prontera P. , Sarchielli P. , Tonelli A. , Bassi M.T. , Cupini L.M. , Caproni S. , Siliquini S. , Donti E. , Calabresi P.
      Cephalalgia34:68-72(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHM2 SER-874
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