Gene name:
ATF4 (CREB2;TXREB) ;
Protein name:
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) ;
Alternative:
Cyclic AMP-responsive element-binding protein 2 (CREB-2;cAMP-responsive element-binding protein 2) ;Activating transcription factor 4 ;Tax-responsive enhancer element-binding protein 67 (TaxREB67) ;DNA-binding protein TAXREB67 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo- or heterodimer. Interacts with the N-terminal region of CEP290. Forms a heterodimer with TXLNG in osteoblasts. Interacts with NEK6.
Function:
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
Subcellular Location:
Cytoplasm
Cell membrane
Nucleus
Cytoplasm
cytoskeleton
centrosome
Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co-localizes with NEK6 in the centrosome.
Protein Attributes:
50:
MTEMSFLSSE | VLVGDLMSPF | DQSGLGAEES | LGLLDDYLEV | AKHFKPHGFS |
100:
SDKAKAGSSE | WLAVDGLVSP | SNNSKEDAFS | GTDWMLEKMD | LKEFDLDALL |
150:
GIDDLETMPD | DLLTTLDDTC | DLFAPLVQET | NKQPPQTVNP | IGHLPESLTK |
200:
PDQVAPFTFL | QPLPLSPGVL | SSTPDHSFSL | ELGSEVDITE | GDRKPDYTAY |
250:
VAMIPQCIKE | EDTPSDNDSG | ICMSPESYLG | SPQHSPSTRG | SPNRSLPSPG |
300:
VLCGSARPKP | YDPPGEKMVA | AKVKGEKLDK | KLKKMEQNKT | AATRYRQKKR |
350:
AEQEALTGEC | KELEKKNEAL | KERADSLAKE | IQYLKDLIEE | VRKARGKKRV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
Rat
ELISA Kit for Human cAMP-dependent transcription factor ATF-4
ELISA Kit for Human cAMP-dependent transcription factor ATF-4
ELISA Kit for Human cAMP-dependent transcription factor ATF-4
ELISA Kit for Human cAMP-dependent transcription factor ATF-4
CLIA Kit for Human cAMP-dependent transcription factor ATF-4
CLIA Kit for Human cAMP-dependent transcription factor ATF-4
CLIA Kit for Human cAMP-dependent transcription factor ATF-4
CLIA Kit for Human cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
Protein for Human cAMP-dependent transcription factor ATF-4
Protein for Human cAMP-dependent transcription factor ATF-4
Protein for Human cAMP-dependent transcription factor ATF-4
Protein for Human cAMP-dependent transcription factor ATF-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT PRO-22
tissue :
Fibroblast .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT PRO-22
tissue :
Leukemic T-cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PRO-22
tissue :
Lung .
tissue :
Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 274-341
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CEP290
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DDIT3
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH NEK6;PHOSPHORYLATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DAPK2 AND ZIPK/DAPK3
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 279-341 IN COMPLEX WITH MOUSE CEBPB