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Index > Protein center > ATF4(Gene name) > Human
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  • ATF4 (Gene name),
  • Cyclic AMP-dependent transcription factor ATF-4 (Protein name ),  ATF4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ATF4(CREB2;TXREB);
    Protein name:
    Cyclic AMP-dependent transcription factor ATF-4(cAMP-dependent transcription factor ATF-4);
    Alternative:
    Cyclic AMP-responsive element-binding protein 2(CREB-2;cAMP-responsive element-binding protein 2);Activating transcription factor 4;Tax-responsive enhancer element-binding protein 67(TaxREB67);DNA-binding protein TAXREB67;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo- or heterodimer. Interacts with the N-terminal region of CEP290. Forms a heterodimer with TXLNG in osteoblasts. Interacts with NEK6.
    Function:
    Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
    Subcellular Location:
    Cytoplasm Cell membrane Nucleus Cytoplasm cytoskeleton centrosome Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co-localizes with NEK6 in the centrosome.
    Protein Attributes:
    Sequence length:
    351
    Sequence:
    50:
    MTEMSFLSSE | VLVGDLMSPF | DQSGLGAEES | LGLLDDYLEV | AKHFKPHGFS | 
    100:
    SDKAKAGSSE | WLAVDGLVSP | SNNSKEDAFS | GTDWMLEKMD | LKEFDLDALL | 
    150:
    GIDDLETMPD | DLLTTLDDTC | DLFAPLVQET | NKQPPQTVNP | IGHLPESLTK | 
    200:
    PDQVAPFTFL | QPLPLSPGVL | SSTPDHSFSL | ELGSEVDITE | GDRKPDYTAY | 
    250:
    VAMIPQCIKE | EDTPSDNDSG | ICMSPESYLG | SPQHSPSTRG | SPNRSLPSPG | 
    300:
    VLCGSARPKP | YDPPGEKMVA | AKVKGEKLDK | KLKKMEQNKT | AATRYRQKKR | 
    350:
    AEQEALTGEC | KELEKKNEAL | KERADSLAKE | IQYLKDLIEE | VRKARGKKRV | 
    351:
    P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    MIM:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human cAMP-dependent transcription factor ATF-4
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    CLIA Kit for Human cAMP-dependent transcription factor ATF-4
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    CLIA Kit for Human cAMP-dependent transcription factor ATF-4
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    U9187b
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    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
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    P9187Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
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    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-4
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-4
    Protein for Human cAMP-dependent transcription factor ATF-4
    Protein for Human cAMP-dependent transcription factor ATF-4
    Protein for Human cAMP-dependent transcription factor ATF-4
    Protein for Human cAMP-dependent transcription factor ATF-4

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    References
    1. 1.
      "Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I."
      Tsujimoto A. , Nyunoya H. , Morita T. , Sato T. , Shimotohno K.
      J. Virol.65:1420-1426(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PRO-22
      tissue: Fibroblast.
    2. 2.
      "Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element."
      Karpinski B.A. , Morle G.D. , Huggenvik J. , Uhler M.D. , Leiden J.M.
      Proc. Natl. Acad. Sci. U.S.A.89:4820-4824(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PRO-22
      tissue: Leukemic T-cell.
    3. 3.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PRO-22
      tissue: Lung.
      tissue: Placenta.
    5. 5.
      "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
      Hai T. , Liu F. , Coukos W.J. , Green M.R.
      Genes Dev.3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 274-341
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    7. 7.
      "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."
      Ohoka N. , Yoshii S. , Hattori T. , Onozaki K. , Hayashi H.
      EMBO J.24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice."
      Yu V.W. , Ambartsoumian G. , Verlinden L. , Moir J.M. , Prud'homme J. , Gauthier C. , Roughley P.J. , St-Arnaud R.
      J. Cell Biol.169:591-601(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXLNG
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CEP290
    10. 10.
      "C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene."
      Su N. , Kilberg M.S.
      J. Biol. Chem.283:35106-35117(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DDIT3
    11. 11.
      "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
      Vaz Meirelles G. , Ferreira Lanza D.C. , da Silva J.C. , Santana Bernachi J. , Paes Leme A.F. , Kobarg J.
      J. Proteome Res.9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NEK6;PHOSPHORYLATION
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."
      Shoval Y. , Berissi H. , Kimchi A. , Pietrokovski S.
      PLoS ONE6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAPK2 AND ZIPK/DAPK3
    14. 14.
      "Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA."
      Podust L.M. , Krezel A.M. , Kim Y.
      J. Biol. Chem.276:505-513(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 279-341 IN COMPLEX WITH MOUSE CEBPB
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