Protein name:
Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) ;
Alternative:
Activating transcription factor 6 alpha (ATF6-alpha) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF.
Function:
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
Subcellular Location:
Processed cyclic AMP-dependent transcription factor ATF-6 alpha
Nucleus
Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Protein Attributes:
50:
MGEPAGVAGT | MESPFSPGLF | HRLDEDWDSA | LFAELGYFTD | TDELQLEAAN |
100:
ETYENNFDNL | DFDLDLMPWE | SDIWDINNQI | CTVKDIKAEP | QPLSPASSSY |
150:
SVSSPRSVDS | YSSTQHVPEE | LDLSSSSQMS | PLSLYGENSN | SLSSAEPLKE |
200:
DKPVTGPRNK | TENGLTPKKK | IQVNSKPSIQ | PKPLLLPAAP | KTQTNSSVPA |
250:
KTIIIQTVPT | LMPLAKQQPI | ISLQPAPTKG | QTVLLSQPTV | VQLQAPGVLP |
300:
SAQPVLAVAG | GVTQLPNHVV | NVVPAPSANS | PVNGKLSVTK | PVLQSTMRNV |
350:
GSDIAVLRRQ | QRMIKNRESA | CQSRKKKKEY | MLGLEARLKA | ALSENEQLKK |
400:
ENGTLKRQLD | EVVSENQRLK | VPSPKRRVVC | VMIVLAFIIL | NYGPMSMLEQ |
450:
DSRRMNPSVS | PANQRRHLLG | FSAKEAQDTS | DGIIQKNSYR | YDHSVSNDKA |
500:
LMVLTEEPLL | YIPPPPCQPL | INTTESLRLN | HELRGWVHRH | EVERTKSRRM |
550:
TNNQQKTRIL | QGALEQGSNS | QLMAVQYTET | TSSISRNSGS | ELQVYYASPR |
600:
SYQDFFEAIR | RRGDTFYVVS | FRRDHLLLPA | TTHNKTTRPK | MSIVLPAINI |
650:
NENVINGQDY | EVMMQIDCQV | MDTRILHIKS | SSVPPYLRDQ | QRNQTNTFFG |
670:
SPPAATEATH | VVSTIPESLQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
ELISA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
ELISA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
CLIA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
CLIA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
CLIA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
Protein for Human cAMP-dependent transcription factor ATF-6 alpha
Protein for Human cAMP-dependent transcription factor ATF-6 alpha
Protein for Human cAMP-dependent transcription factor ATF-6 alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS PRO-145 AND SER-157
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Cervix carcinoma .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-202;VARIANT VAL-67
tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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