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Index > Protein center > ATF6(Gene name) > Human
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  • ATF6 (Gene name),
  • Cyclic AMP-dependent transcription factor ATF-6 alpha (Protein name ),  ATF6A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ATF6;
    Protein name:
    Cyclic AMP-dependent transcription factor ATF-6 alpha(cAMP-dependent transcription factor ATF-6 alpha);
    Alternative:
    Activating transcription factor 6 alpha(ATF6-alpha);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF.
    Function:
    Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
    Subcellular Location:
    Processed cyclic AMP-dependent transcription factor ATF-6 alpha Nucleus Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
    Protein Attributes:
    Sequence length:
    670
    Sequence:
    50:
    MGEPAGVAGT | MESPFSPGLF | HRLDEDWDSA | LFAELGYFTD | TDELQLEAAN | 
    100:
    ETYENNFDNL | DFDLDLMPWE | SDIWDINNQI | CTVKDIKAEP | QPLSPASSSY | 
    150:
    SVSSPRSVDS | YSSTQHVPEE | LDLSSSSQMS | PLSLYGENSN | SLSSAEPLKE | 
    200:
    DKPVTGPRNK | TENGLTPKKK | IQVNSKPSIQ | PKPLLLPAAP | KTQTNSSVPA | 
    250:
    KTIIIQTVPT | LMPLAKQQPI | ISLQPAPTKG | QTVLLSQPTV | VQLQAPGVLP | 
    300:
    SAQPVLAVAG | GVTQLPNHVV | NVVPAPSANS | PVNGKLSVTK | PVLQSTMRNV | 
    350:
    GSDIAVLRRQ | QRMIKNRESA | CQSRKKKKEY | MLGLEARLKA | ALSENEQLKK | 
    400:
    ENGTLKRQLD | EVVSENQRLK | VPSPKRRVVC | VMIVLAFIIL | NYGPMSMLEQ | 
    450:
    DSRRMNPSVS | PANQRRHLLG | FSAKEAQDTS | DGIIQKNSYR | YDHSVSNDKA | 
    500:
    LMVLTEEPLL | YIPPPPCQPL | INTTESLRLN | HELRGWVHRH | EVERTKSRRM | 
    550:
    TNNQQKTRIL | QGALEQGSNS | QLMAVQYTET | TSSISRNSGS | ELQVYYASPR | 
    600:
    SYQDFFEAIR | RRGDTFYVVS | FRRDHLLLPA | TTHNKTTRPK | MSIVLPAINI | 
    650:
    NENVINGQDY | EVMMQIDCQV | MDTRILHIKS | SSVPPYLRDQ | QRNQTNTFFG | 
    670:
    SPPAATEATH | VVSTIPESLQ | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    Pfam:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
    ELISA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
    ELISA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
    CLIA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
    CLIA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
    CLIA Kit for Human cAMP-dependent transcription factor ATF-6 alpha
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-6 alpha
    Protein for Human cAMP-dependent transcription factor ATF-6 alpha
    Protein for Human cAMP-dependent transcription factor ATF-6 alpha
    Protein for Human cAMP-dependent transcription factor ATF-6 alpha

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    Precision
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    Linearity
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    References
    1. 1.
      "Interaction of ATF6 and serum response factor."
      Zhu C. , Johansen F.E. , Prywes R.
      Mol. Cell. Biol.17:4957-4966(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS LEU-67; PRO-145 AND SER-157
      tissue: Cervix carcinoma.
    2. 2.
      "Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors."
      Yoshida H. , Haze K. , Yanagi H. , Yura T. , Mori K.
      J. Biol. Chem.273:33741-33749(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS PRO-145 AND SER-157
      tissue: Cervix carcinoma.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-202;VARIANT VAL-67
      tissue: Pancreas.
    5. 5.
      "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
      Hai T. , Liu F. , Coukos W.J. , Green M.R.
      Genes Dev.3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-369
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    7. 7.
      "Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress."
      Haze K. , Yoshida H. , Yanagi H. , Yura T. , Mori K.
      Mol. Biol. Cell10:3787-3799(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    8. 8.
      "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs."
      Ye J. , Rawson R.B. , Komuro R. , Chen X. , Dave U.P. , Prywes R. , Brown M.S. , Goldstein J.L.
      Mol. Cell6:1355-1364(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING BY PS1 AND PS2;MUTAGENESIS OF ASN-391; PRO-394; 415-ARG-ARG-416 AND LEU-419
    9. 9.
      "Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response."
      Yoshida H. , Okada T. , Haze K. , Yanagi H. , Yura T. , Negishi M. , Mori K.
      Mol. Cell. Biol.21:1239-1248(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis."
      Hai T. , Hartman M.G.
      Gene273:1-11(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response."
      Hong M. , Luo S. , Baumeister P. , Huang J.M. , Gogia R.K. , Li M. , Lee A.S.
      J. Biol. Chem.279:11354-11363(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-472; ASN-584 AND ASN-643;MUTAGENESIS OF THR-474; THR-586 AND THR-645
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THBS4
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