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Index > Protein center > Atg3(Gene name) > Mouse
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  • Atg3 (Gene name),
  • Ubiquitin-like-conjugating enzyme ATG3 (Protein name ),  ATG3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Atg3(Apg3l);
    Protein name:
    Ubiquitin-like-conjugating enzyme ATG3;
    Alternative:
    Autophagy-related protein 3(APG3-like);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.
    Function:
    E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    314
    Sequence:
    50:
    MQNVINTVKG | KALEVAEYLT | PVLKESKFKE | TGVITPEEFV | AAGDHLVHHC | 
    100:
    PTWQWATGEE | LKVKAYLPTD | KQFLVTKNVP | CYKRCKQMEY | SDELEAIIEE | 
    150:
    DDGDGGWVDT | YHNTGITGIT | EAVKEITLES | KDSIKLQDCS | ALCDEEDEED | 
    200:
    EGEAADMEEY | EESGLLETDE | ATLDTRKIVE | ACKAKADAGG | EDAILQTRTY | 
    250:
    DLYITYDKYY | QTPRLWLFGY | DEQRQPLTVE | HMYEDISQDH | VKKTVTIENH | 
    300:
    PHLPPPPMCS | VHPCRHAEVM | KKIIETVAEG | GGELGVHMYL | LIFLKFVQAV | 
    314:
    IPTIEYDYTR | HFTM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    ELISA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    ELISA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    ELISA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    CLIA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    CLIA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    CLIA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    CLIA Kit for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Polyclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Polyclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Polyclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Polyclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Monoclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Monoclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Monoclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Monoclonal Antibody for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Protein for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Protein for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Protein for Mouse Ubiquitin-like-conjugating enzyme ATG3
    Protein for Mouse Ubiquitin-like-conjugating enzyme ATG3

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    Linearity
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    References
    1. 1.
      "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
      Tanida I. , Tanida-Miyake E. , Komatsu M. , Ueno T. , Kominami E.
      J. Biol. Chem.277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone marrow.
      tissue: Cerebellum.
      tissue: Colon.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Kidney.
    4. 4.
      "The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy."
      Fujita N. , Itoh T. , Omori H. , Fukuda M. , Noda T. , Yoshimori T.
      Mol. Biol. Cell19:2092-2100(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG12
    5. 5.
      "The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice."
      Sou Y.S. , Waguri S. , Iwata J. , Ueno T. , Fujimura T. , Hara T. , Sawada N. , Yamada A. , Mizushima N. , Uchiyama Y. , Kominami E. , Tanaka K. , Komatsu M.
      Mol. Biol. Cell19:4762-4775(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death."
      Radoshevich L. , Murrow L. , Chen N. , Fernandez E. , Roy S. , Fung C. , Debnath J.
      Cell142:590-600(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CONJUGATION TO ATG12 AT LYS-243;MUTAGENESIS OF LYS-71; LYS-83; LYS-243; CYS-264; LYS-271 AND LYS-295
    7. 7.
      "Vaccinia virus leads to ATG12-ATG3 conjugation and deficiency in autophagosome formation."
      Moloughney J.G. , Monken C.E. , Tao H. , Zhang H. , Thomas J.D. , Lattime E.C. , Jin S.
      Autophagy7:1434-1447(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12
    8. 8.
      "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
      Tang Z. , Lin M.G. , Stowe T.R. , Chen S. , Zhu M. , Stearns T. , Franco B. , Zhong Q.
      Nature502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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