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Index > Protein center > Atg5(Gene name) > Mouse
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  • Atg5 (Gene name),
  • Autophagy protein 5 (Protein name ),  ATG5_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Atg5(Apg5l);
    Protein name:
    Autophagy protein 5;
    Alternative:
    APG5-like;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed.
    Subcellular Location:
    Cytoplasm Cytoplasmic or associated with cytoplasmic isolation membrane.
    Protein Attributes:
    Sequence length:
    275
    Sequence:
    50:
    MTDDKDVLRD | VWFGRIPTCF | TLYQDEITER | EAEPYYLLLP | RVSYLTLVTD | 
    100:
    KVKKHFQKVM | RQEDVSEIWF | EYEGTPLKWH | YPIGLLFDLL | ASSSALPWNI | 
    150:
    TVHFKSFPEK | DLLHCPSKDA | VEAHFMSCMK | EADALKHKSQ | VINEMQKKDH | 
    200:
    KQLWMGLQND | RFDQFWAINR | KLMEYPPEEN | GFRYIPFRIY | QTTTERPFIQ | 
    250:
    KLFRPVAADG | QLHTLGDLLR | EVCPSAVAPE | DGEKRSQVMI | HGIEPMLETP | 
    275:
    LQWLSEHLSY | PDNFLHISIV | PQPTD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Autophagy protein 5
    Cat.:
    E15032h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Autophagy protein 5
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Autophagy protein 5
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Autophagy protein 5
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Autophagy protein 5
    Cat.:
    E15032m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Autophagy protein 5
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Autophagy protein 5
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Autophagy protein 5
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Autophagy protein 5
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Autophagy protein 5
    Cat.:
    U15032h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Autophagy protein 5
    Polyclonal Antibody for Mouse Autophagy protein 5
    Polyclonal Antibody for Mouse Autophagy protein 5
    Polyclonal Antibody for Mouse Autophagy protein 5
    Polyclonal Antibody for Mouse Autophagy protein 5
    Monoclonal Antibody for Mouse Autophagy protein 5
    Monoclonal Antibody for Mouse Autophagy protein 5
    Monoclonal Antibody for Mouse Autophagy protein 5
    Monoclonal Antibody for Mouse Autophagy protein 5
    Monoclonal Antibody for Mouse Autophagy protein 5
    Protein for Mouse Autophagy protein 5
    Protein for Mouse Autophagy protein 5
    Protein for Mouse Autophagy protein 5
    Protein for Mouse Autophagy protein 5
    Protein for Mouse Autophagy protein 5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells."
      Mizushima N. , Yamamoto A. , Hatano M. , Kobayashi Y. , Kabeya Y. , Suzuki K. , Tokuhisa T. , Ohsumi Y. , Yoshimori T.
      J. Cell Biol.152:657-668(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CONJUGATION TO ATG12;MUTAGENESIS OF LYS-130
      tissue: Embryonic stem cell.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Brain.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method."
      Mizushima N. , Yoshimori T. , Ohsumi Y.
      FEBS Lett.532:450-454(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG10;CONJUGATION TO ATG12
    5. 5.
      "The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification."
      Nemoto T. , Tanida I. , Tanida-Miyake E. , Minematsu-Ikeguchi N. , Yokota M. , Ohsumi M. , Ueno T. , Kominami E.
      J. Biol. Chem.278:39517-39526(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12 BY ATG10;FUNCTION
    6. 6.
      "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate."
      Mizushima N. , Kuma A. , Kobayashi Y. , Yamamoto A. , Matsubae M. , Takao T. , Natsume T. , Ohsumi Y. , Yoshimori T.
      J. Cell Sci.116:1679-1688(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH ATG12 AND ATG16L
    7. 7.
      "Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death."
      Nishiyama J. , Miura E. , Mizushima N. , Watanabe M. , Yuzaki M.
      Autophagy3:591-596(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "A critical role for the autophagy gene Atg5 in T cell survival and proliferation."
      Pua H.H. , Dzhagalov I. , Chuck M. , Mizushima N. , He Y.W.
      J. Exp. Med.204:25-31(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "The autophagy gene ATG5 plays an essential role in B lymphocyte development."
      Miller B.C. , Zhao Z. , Stephenson L.M. , Cadwell K. , Pua H.H. , Lee H.K. , Mizushima N.N. , Iwasaki A. , He Y.W. , Swat W. , Virgin H.W.
      Autophagy4:309-314(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice."
      Sou Y.S. , Waguri S. , Iwata J. , Ueno T. , Fujimura T. , Hara T. , Sawada N. , Yamada A. , Mizushima N. , Uchiyama Y. , Kominami E. , Tanaka K. , Komatsu M.
      Mol. Biol. Cell19:4762-4775(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12
    11. 11.
      "Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation."
      Zhang J. , Randall M.S. , Loyd M.R. , Dorsey F.C. , Kundu M. , Cleveland J.L. , Ney P.A.
      Blood114:157-164(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12
    12. 12.
      "Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice."
      Baerga R. , Zhang Y. , Chen P.H. , Goldman S. , Jin S.
      Autophagy5:1118-1130(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "In vivo requirement for Atg5 in antigen presentation by dendritic cells."
      Lee H.K. , Mattei L.M. , Steinberg B.E. , Alberts P. , Lee Y.H. , Chervonsky A. , Mizushima N. , Grinstein S. , Iwasaki A.
      Immunity32:227-239(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
    15. 15.
      "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
      Tang Z. , Lin M.G. , Stowe T.R. , Chen S. , Zhu M. , Stearns T. , Franco B. , Zhong Q.
      Nature502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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