Atn1 ELISA Kit for Mouse(Mus musculus) | EIAab.comAtn1 ELISA Kit for Mouse(Mus musculus)

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Atn1 (Gene name),

Atrophin-1 (Protein name ), ATN1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Atn1(Drpla);

Protein name:

Atrophin-1;

Alternative:

Dentatorubral-pallidoluysian atrophy protein homolog;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with BAIAP2, WWP1, WWP2, WWP3 and RERE. Interacts (via its N-terminus) with MTG8; the interaction enhances transcriptional repression of MTG8 (By similarity). Interacts with NR2E1; the interaction represses the transcriptional activity of NR2E1. Interacts with FAT1 (via a C-terminus domain).

Function:

Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation.

Subcellular Location:

Nucleus Cytoplasm perinuclear region Cell junction Nucleus Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots.

Protein Attributes:

Sequence length:

1175

Sequence:

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1050:

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1150:

1175:

PLHSVPLPAQ | EDYYSHLKKE | SDKPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O35126

Pfam:

PF03154

UniGene:

Mm.333380

KEGG:

mmu:13498

Uniprot:

O35126

FOR

ELISA Kit for Mouse Atrophin-1

CLIA Kit for Mouse Atrophin-1

Polyclonal Antibody for Mouse Atrophin-1

Monoclonal Antibody for Mouse Atrophin-1

Protein for Mouse Atrophin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of murine homologue dentatorubral-pallidoluysian atrophy (DRPLA) cDNA: strong conservation of a polymorphic CAG repeat in the murine gene."
Oyake M. , Onodera O. , Shiroishi T. , Takano H. , Takahashi Y. , Komonami R. , Moriwaki K. , Ikeuchi T. , Igarashi S. , Tanaka H. , Tsuji S.
Genomics40:205-207(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;POLYMORPHISM OF POLY-GLN REGION
2.

"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6."
Ansari-Lari M.A. , Oeltjen J.C. , Schwartz S. , Zhang Z. , Muzny D.M. , Lu J. , Gorrell J.H. , Chinault A.C. , Belmont J.W. , Miller W. , Gibbs R.A.
Genome Res.8:29-40(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
5.

"Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1."
Zhang C.L. , Zou Y. , Yu R.T. , Gage F.H. , Evans R.M.
Genes Dev.20:1308-1320(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR2E1;FUNCTION
6.

"Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice."
Sato T. , Miura M. , Yamada M. , Yoshida T. , Wood J.D. , Yazawa I. , Masuda M. , Suzuki T. , Shin R.M. , Yau H.J. , Liu F.C. , Shimohata T. , Onodera O. , Ross C.A. , Katsuki M. , Takahashi H. , Kano M. , Aosaki T. , more...
Hum. Mol. Genet.18:723-736(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERISTICS OF THE MOUSE MODEL OF DRPLA
7.

"Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells."
Hou R. , Sibinga N.E.
J. Biol. Chem.284:6955-6965(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAT1;INDUCTION;FUNCTION

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