Atp5a1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAtp5a1 ELISA Kit for Rat(Rattus norvegicus)

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Atp5a1 (Gene name),

ATP synthase subunit alpha, mitochondrial (Protein name ), ATPA_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Atp5a1;

Protein name:

ATP synthase subunit alpha, mitochondrial;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro).

Function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.

Subcellular Location:

Mitochondrion inner membrane Cell membrane Peripheral membrane protein Extracellular side Colocalizes with HRG on the cell surface of T-cells.

Protein Attributes:

Sequence length:

553

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

553:

FEP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:65262

STRING:

10116.ENSRNOP00000022892

Pfam:

PF00006

UniGene:

Rn.40255

String:

P15999

SMR:

P15999

Uniprot:

P15999

FOR

ELISA Kit for Rat ATP synthase subunit alpha, mitochondrial

CLIA Kit for Rat ATP synthase subunit alpha, mitochondrial

Polyclonal Antibody for Rat ATP synthase subunit alpha, mitochondrial

Monoclonal Antibody for Rat ATP synthase subunit alpha, mitochondrial

Protein for Rat ATP synthase subunit alpha, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Prostate.
2.

"Mitochondrial ATP synthase. cDNA cloning, amino acid sequence, overexpression, and properties of the rat liver alpha subunit."
Lee J.H. , Garboczi D.N. , Thomas P.J. , Pedersen P.L.
J. Biol. Chem.265:4664-4669(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-553
tissue: Liver.
3.

Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Kang S.U.
Submitted (2007-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 46-58; 104-123; 134-161; 195-204; 335-347; 403-416; 435-463; 467-493; 507-527 AND 540-553;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Brain.
tissue: Hippocampus.
tissue: Spinal cord.
4.

Frey B.A.J. , Weber F.E. , Fett R. , Pette D.
Submitted (1990-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-553
tissue: Muscle.
5.

"Identification of two proteins associated with mammalian ATP synthase."
Meyer B. , Wittig I. , Trifilieff E. , Karas M. , Schaegger H.
Mol. Cell. Proteomics6:1690-1699(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE ATP SYNTHASE COMPLEX
6.

"Identification of novel immunodominant epididymal sperm proteins using combinatorial approach."
Khan S.A. , Suryawanshi A.R. , Ranpura S.A. , Jadhav S.V. , Khole V.V.
Reproduction138:81-93(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;TISSUE SPECIFICITY
7.

"Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase."
Alavian K.N. , Li H. , Collis L. , Bonanni L. , Zeng L. , Sacchetti S. , Lazrove E. , Nabili P. , Flaherty B. , Graham M. , Chen Y. , Messerli S.M. , Mariggio M.A. , Rahner C. , McNay E. , Shore G.C. , Smith P.J. , Hardwick J.M. , more...
Nat. Cell Biol.13:1224-1233(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL2L1
8.

"Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods."
Cao W. , Cao J. , Huang J. , Yao J. , Yan G. , Xu H. , Yang P.
PLoS ONE8:E76399-E76399(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-76
9.

"The 2.8-A structure of rat liver F1-ATPase: configuration of a critical intermediate in ATP synthesis/hydrolysis."
Bianchet M.A. , Hullihen J. , Pedersen P.L. , Amzel L.M.
Proc. Natl. Acad. Sci. U.S.A.95:11065-11070(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 44-553

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