Atrx ELISA Kit for Mouse(Mus musculus) | EIAab.comAtrx ELISA Kit for Mouse(Mus musculus)

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Atrx (Gene name),

Transcriptional regulator ATRX (Protein name ), ATRX_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Atrx(Hp1bp2;Xnp);

Protein name:

Transcriptional regulator ATRX;

Alternative:

HP1 alpha-interacting protein;ATP-dependent helicase ATRX;Heterochromatin protein 2;HP1-BP38 protein;X-linked nuclear protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Probably binds EZH2. Binds annexin V in a calcium and phosphatidylcholine/phosphatidylserine-dependent manner. Interacts directly with CBX5 via the PxVxL motif.

Function:

Could be a global transcriptional regulator. Modifies gene expression by affecting chromatin.

Subcellular Location:

Nucleus Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with HP1.

Protein Attributes:

Sequence length:

2476

Sequence:

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2450:

2476:

QPPPLQRAPP | PTVRSKNPGP | SPGKSM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q61687

UniGene:

Mm.10141

KEGG:

mmu:22589

Pfam:

PF00271

SMR:

Q61687

Uniprot:

Q61687

FOR

ELISA Kit for Mouse Transcriptional regulator ATRX

CLIA Kit for Mouse Transcriptional regulator ATRX

Polyclonal Antibody for Mouse Transcriptional regulator ATRX

Monoclonal Antibody for Mouse Transcriptional regulator ATRX

Protein for Mouse Transcriptional regulator ATRX

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains."
Picketts D.J. , Tastan A.O. , Higgs D.R. , Gibbons R.J.
Mamm. Genome9:400-403(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors."
le Douarin B. , Nielsen A.L. , Garnier J.-M. , Ichinose H. , Jeanmougin F. , Losson R. , Chambon P.
EMBO J.15:6701-6715(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 325-1176
4.

"Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes."
McDowell T.L. , Gibbons R.J. , Sutherland H. , O'Rourke D.M. , Bickmore W.A. , Pombo A. , Turley H. , Gatter K. , Picketts D.J. , Buckle V.J. , Chapman L. , Rhodes D. , Higgs D.R.
Proc. Natl. Acad. Sci. U.S.A.96:13983-13988(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ASSOCIATION WITH PERICENTROMERIC HETEROCHROMATIN
5.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-89; SER-717; SER-719; SER-801 AND SER-1339;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
6.

"Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."
Nan X. , Hou J. , Maclean A. , Nasir J. , Lafuente M.J. , Shu X. , Kriaucionis S. , Bird A.
Proc. Natl. Acad. Sci. U.S.A.104:2709-2714(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MECP2
7.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
9.

"ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner."
Law M.J. , Lower K.M. , Voon H.P. , Hughes J.R. , Garrick D. , Viprakasit V. , Mitson M. , De Gobbi M. , Marra M. , Morris A. , Abbott A. , Wilder S.P. , Taylor S. , Santos G.M. , Cross J. , Ayyub H. , Jones S. , Ragoussis J. , more...
Cell143:367-378(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Distinct factors control histone variant H3.3 localization at specific genomic regions."
Goldberg A.D. , Banaszynski L.A. , Noh K.M. , Lewis P.W. , Elsaesser S.J. , Stadler S. , Dewell S. , Law M. , Guo X. , Li X. , Wen D. , Chapgier A. , DeKelver R.C. , Miller J.C. , Lee Y.L. , Boydston E.A. , Holmes M.C. , Gregory P.D. , more...
Cell140:678-691(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH HISTONE H3.3
11.

"The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3."
Drane P. , Ouararhni K. , Depaux A. , Shuaib M. , Hamiche A.
Genes Dev.24:1253-1265(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH HISTONE H3.3
12.

"Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin."
Eustermann S. , Yang J.C. , Law M.J. , Amos R. , Chapman L.M. , Jelinska C. , Garrick D. , Clynes D. , Gibbons R.J. , Rhodes D. , Higgs D.R. , Neuhaus D.
Nat. Struct. Mol. Biol.18:777-782(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-239 AND VAL-580
13.

"Citrullination regulates pluripotency and histone H1 binding to chromatin."
Christophorou M.A. , Castelo-Branco G. , Halley-Stott R.P. , Oliveira C.S. , Loos R. , Radzisheuskaya A. , Mowen K.A. , Bertone P. , Silva J.C. , Zernicka-Goetz M. , Nielsen M.L. , Gurdon J.B. , Kouzarides T.
Nature507:104-108(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CITRULLINATION AT ARG-1063
14.

"ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain."
Kernohan K.D. , Jiang Y. , Tremblay D.C. , Bonvissuto A.C. , Eubanks J.H. , Mann M.R. , Berube N.G.
Dev. Cell18:191-202(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MECP2; SMC1 AND SMC3
15.

"ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells."
Wong L.H. , McGhie J.D. , Sim M. , Anderson M.A. , Ahn S. , Hannan R.D. , George A.J. , Morgan K.A. , Mann J.R. , Choo K.H.
Genome Res.20:351-360(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH HISTONE H3.3
16.

"ATRX dysfunction induces replication defects in primary mouse cells."
Clynes D. , Jelinska C. , Xella B. , Ayyub H. , Taylor S. , Mitson M. , Bachrati C.Z. , Higgs D.R. , Gibbons R.J.
PLoS ONE9:E92915-E92915(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAD50; MRE11A AND NBN

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