ATR ELISA Kit for Human(Homo sapiens) | EIAab.comATR ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > ATR(Gene name) > Human

ATR (Gene name),

Serine/threonine-protein kinase ATR (Protein name ), ATR_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

ATR(FRP1);

Protein name:

Serine/threonine-protein kinase ATR;

Alternative:

FRAP-related protein 1;Ataxia telangiectasia and Rad3-related protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms an heterodimer with ATRIP. Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with BCR-ABL after genotoxic stress. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164. Interacts with TELO2 AND TTI1.

Function:

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Subcellular Location:

Nucleus Nucleus PML body Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.

Protein Attributes:

Sequence length:

2644

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1400:

1450:

1500:

1550:

1600:

1650:

1700:

1750:

1800:

1850:

1900:

1950:

2000:

2050:

2100:

2150:

2200:

2250:

2300:

2350:

2400:

2450:

2500:

2550:

2600:

2644:

GVIKTRNRVT | GLPLSIEGHV | HYLIQEATDE | NLLCQMYLGW | TPYM

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q13535

STRING:

9606.ENSP00000343741

UniGene:

Hs.271791

Pfam:

PF02259

KEGG:

hsa:545

SMR:

Q13535

MIM:

210600

Uniprot:

Q13535

FOR

ELISA Kit for Human Serine/threonine-protein kinase ATR

Cat.:

E15117m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Serine/threonine-protein kinase ATR

Cat.:

E15117h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Serine/threonine-protein kinase ATR

Cat.:

U15117m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Serine/threonine-protein kinase ATR

Cat.:

U15117h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Serine/threonine-protein kinase ATR

Cat.:

P15117Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Serine/threonine-protein kinase ATR

Cat.:

P15117Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Serine/threonine-protein kinase ATR

Protein for Human Serine/threonine-protein kinase ATR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The Schizosaccharomyces pombe rad3 checkpoint gene."
Bentley N.J. , Holtzman D.A. , Flaggs G. , Keegan K.S. , DeMaggio A. , Ford J.C. , Hoekstra M. , Carr A.M.
EMBO J.15:6641-6651(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein."
Cimprich K.A. , Shin T.B. , Keith C.T. , Schreiber S.L.
Proc. Natl. Acad. Sci. U.S.A.93:2850-2855(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: T-cell.
3.

"Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR."
Mannino J.L. , Kim W.-J. , Wernick M. , Nguyen S.V. , Braquet R. , Adamson A.W. , Den Z. , Batzer M.A. , Collins C.C. , Brown K.D.
Gene272:35-43(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 433-526 (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
4.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2155-2644 (ISOFORM 3)
tissue: Brain.
5.

"The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes."
Keegan K.S. , Holtzman D.A. , Plug A.W. , Christenson E.R. , Brainerd E.E. , Flaggs G. , Bentley N.J. , Taylor E.M. , Meyn M.S. , Moss S.B. , Carr A.M. , Ashley T. , Hoekstra M.F.
Genes Dev.10:2423-2437(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin."
Sarkaria J.N. , Tibbetts R.S. , Busby E.C. , Kennedy A.P. , Hill D.E. , Abraham R.T.
Cancer Res.58:4375-4382(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
7.

"Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints."
Cliby W.A. , Roberts C.J. , Cimprich K.A. , Stringer C.M. , Lamb J.R. , Schreiber S.L. , Friend S.H.
EMBO J.17:159-169(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;AUTOPHOSPHORYLATION;MUTAGENESIS OF ASP-2475
8.

"Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control."
Wright J.A. , Keegan K.S. , Herendeen D.R. , Bentley N.J. , Carr A.M. , Hoekstra M.F. , Concannon P.
Proc. Natl. Acad. Sci. U.S.A.95:7445-7450(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-2494
9.

"Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4."
Schmidt D.R. , Schreiber S.L.
Biochemistry38:14711-14717(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC2;IDENTIFICATION IN A COMPLEX CONTAINING HDAC2 AND CHD4
10.

"A role for ATR in the DNA damage-induced phosphorylation of p53."
Tibbetts R.S. , Brumbaugh K.M. , Williams J.M. , Sarkaria J.N. , Cliby W.A. , Shieh S.-Y. , Taya Y. , Prives C. , Abraham R.T.
Genes Dev.13:152-157(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-2327 AND ASP-2475
11.

"Substrate specificities and identification of putative substrates of ATM kinase family members."
Kim S.-T. , Lim D.-S. , Canman C.E. , Kastan M.B.
J. Biol. Chem.274:37538-37543(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COFACTOR;FUNCTION
12.

"ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK."
Hall-Jackson C.A. , Cross D.A.E. , Morrice N. , Smythe C.
Oncogene18:6707-6713(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;AUTOPHOSPHORYLATION;MUTAGENESIS OF ASP-2494;ENZYME REGULATION
13.

"Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint."
Liu Q. , Guntuku S. , Cui X.-S. , Matsuoka S. , Cortez D. , Tamai K. , Luo G. , Carattini-Rivera S. , DeMayo F. , Bradley A. , Donehower L.A. , Elledge S.J.
Genes Dev.14:1448-1459(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress."
Tibbetts R.S. , Cortez D. , Brumbaugh K.M. , Scully R. , Livingston D. , Elledge S.J. , Abraham R.T.
Genes Dev.14:2989-3002(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-2327
15.

"Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress."
Ward I.M. , Chen J.
J. Biol. Chem.276:47759-47762(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses."
Bao S. , Tibbetts R.S. , Brumbaugh K.M. , Fang Y. , Richardson D.A. , Ali A. , Chen S.M. , Abraham R.T. , Wang X.-F.
Nature411:969-974(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAD17
17.

"ATR and ATRIP: partners in checkpoint signaling."
Cortez D. , Guntuku S. , Qin J. , Elledge S.J.
Science294:1713-1716(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH ATRIP
18.

"ATR regulates fragile site stability."
Casper A.M. , Nghiem P. , Arlt M.F. , Glover T.W.
Cell111:779-789(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Hypoxia links ATR and p53 through replication arrest."
Hammond E.M. , Denko N.C. , Dorie M.J. , Abraham R.T. , Giaccia A.J.
Mol. Cell. Biol.22:1834-1843(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
20.

"Preferential binding of ATR protein to UV-damaged DNA."
Uensal-Kacmaz K. , Makhov A.M. , Griffith J.D. , Sancar A.
Proc. Natl. Acad. Sci. U.S.A.99:6673-6678(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;MUTAGENESIS OF LYS-2327
21.

"ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation."
Barr S.M. , Leung C.G. , Chang E.E. , Cimprich K.A.
Curr. Biol.13:1047-1051(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-2475
22.

"Human claspin is required for replication checkpoint control."
Chini C.C.S. , Chen J.
J. Biol. Chem.278:30057-30062(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLSPN
23.

"MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation."
Wang Y. , Qin J.
Proc. Natl. Acad. Sci. U.S.A.100:15387-15392(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MSH2;IDENTIFICATION BY MASS SPECTROMETRY
24.

"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes."
Zou L. , Elledge S.J.
Science300:1542-1548(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;IDENTIFICATION IN A COMPLEX WITH RPA AND ATRIP
25.

"BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint."
Dierov J. , Dierova R. , Carroll M.
Cancer Cell5:275-285(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCR-ABL
26.

"UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress."
Ward I.M. , Minn K. , Chen J.
J. Biol. Chem.279:9677-9680(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
27.

"Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase."
Dart D.A. , Adams K.E. , Akerman I. , Lakin N.D.
J. Biol. Chem.279:16433-16440(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;SUBCELLULAR LOCATION
28.

"ATR couples FANCD2 monoubiquitination to the DNA-damage response."
Andreassen P.R. , D'Andrea A.D. , Taniguchi T.
Genes Dev.18:1958-1963(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
29.

"Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway."
Alderton G.K. , Joenje H. , Varon R. , Borglum A.D. , Jeggo P.A. , O'Driscoll M.
Hum. Mol. Genet.13:3127-3138(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities."
Uensal-Kacmaz K. , Sancar A.
Mol. Cell. Biol.24:1292-1300(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;IDENTIFICATION IN A COMPLEX WITH ATRIP AND RPA1;DNA-BINDING;ENZYME REGULATION
31.

"Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases."
Cortez D. , Glick G. , Elledge S.J.
Proc. Natl. Acad. Sci. U.S.A.101:10078-10083(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
32.

"The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR."
Park B.-J. , Kang J.W. , Lee S.W. , Choi S.-J. , Shin Y.K. , Ahn Y.H. , Choi Y.H. , Choi D. , Lee K.S. , Kim S.
Cell120:209-221(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EEF1E1
33.

"Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage."
Falck J. , Coates J. , Jackson S.P.
Nature434:605-611(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATRIP
34.

"Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1."
Sivasubramaniam S. , Sun X. , Pan Y.R. , Wang S. , Lee E.Y.
Genes Dev.22:587-600(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CEP164;SUBCELLULAR LOCATION
35.

"A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome."
O'Driscoll M. , Ruiz-Perez V.L. , Woods C.G. , Jeggo P.A. , Goodship J.A.
Nat. Genet.33:497-501(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SCKL1
36.

"Protein phosphatase 5 is required for ATR-mediated checkpoint activation."
Zhang J. , Bao S. , Furumai R. , Kucera K.S. , Ali A. , Dean N.M. , Wang X.F.
Mol. Cell. Biol.25:9910-9919(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DNA DAMAGE RESPONSE;INTERACTION WITH PPP5C;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION
37.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428 AND THR-1989;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
38.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
39.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
40.

"A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability."
Hurov K.E. , Cotta-Ramusino C. , Elledge S.J.
Genes Dev.24:1939-1950(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TTI1
41.

"Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."
Takai H. , Xie Y. , de Lange T. , Pavletich N.P.
Genes Dev.24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TELO2
42.

"Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly."
Kaizuka T. , Hara T. , Oshiro N. , Kikkawa U. , Yonezawa K. , Takehana K. , Iemura S. , Natsume T. , Mizushima N.
J. Biol. Chem.285:20109-20116(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TELO2 AND TTI1
43.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
44.

"Protein phosphatase 5 is necessary for ATR-mediated DNA repair."
Kang Y. , Cheong H.M. , Lee J.H. , Song P.I. , Lee K.H. , Kim S.Y. , Jun J.Y. , You H.J.
Biochem. Biophys. Res. Commun.404:476-481(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DNA REPAIR;PHOSPHORYLATION AT SER-428
45.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
46.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-64; TYR-90; ASN-297; ILE-316; MET-959; HIS-1087; GLY-1213; PRO-1488; ASN-1607; SER-1612; GLY-2002; ALA-2120; ASP-2132; ILE-2233; GLN-2425; ALA-2434; LYS-2438 AND GLN-2537
47.

"Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome."
Tanaka A. , Weinel S. , Nagy N. , O'Driscoll M. , Lai-Cheong J.E. , Kulp-Shorten C.L. , Knable A. , Carpenter G. , Fisher S.A. , Hiragun M. , Yanase Y. , Hide M. , Callen J. , McGrath J.A.
Am. J. Hum. Genet.90:511-517(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FCTCS ARG-2144

Product Feedback Wall

* Email:
*Comments: