Gene name:
ADAMTS1(KIAA1346;METH1);
Protein name:
A disintegrin and metalloproteinase with thrombospondin motifs 1(ADAM-TS 1;ADAM-TS1;ADAMTS-1);
Alternative:
METH-1;
Organism:
Human (Homo sapiens).
General annotation
Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein attributes
50:
MQRAVPEGFG | RRKLGSDMGN | AERAPGSRSF | GPVPTLLLLA | AALLAVSDAL |
100:
GRPSEEDEEL | VVPELERAPG | HGTTRLRLHA | FDQQLDLELR | PDSSFLAPGF |
150:
TLQNVGRKSG | SETPLPETDL | AHCFYSGTVN | GDPSSAAALS | LCEGVRGAFY |
200:
LLGEAYFIQP | LPAASERLAT | AAPGEKPPAP | LQFHLLRRNR | QGDVGGTCGV |
250:
VDDEPRPTGK | AETEDEDEGT | EGEDEGAQWS | PQDPALQGVG | QPTGTGSIRK |
300:
KRFVSSHRYV | ETMLVADQSM | AEFHGSGLKH | YLLTLFSVAA | RLYKHPSIRN |
350:
SVSLVVVKIL | VIHDEQKGPE | VTSNAALTLR | NFCNWQKQHN | PPSDRDAEHY |
400:
DTAILFTRQD | LCGSQTCDTL | GMADVGTVCD | PSRSCSVIED | DGLQAAFTTA |
450:
HELGHVFNMP | HDDAKQCASL | NGVNQDSHMM | ASMLSNLDHS | QPWSPCSAYM |
500:
ITSFLDNGHG | ECLMDKPQNP | IQLPGDLPGT | SYDANRQCQF | TFGEDSKHCP |
550:
DAASTCSTLW | CTGTSGGVLV | CQTKHFPWAD | GTSCGEGKWC | INGKCVNKTD |
600:
RKHFDTPFHG | SWGMWGPWGD | CSRTCGGGVQ | YTMRECDNPV | PKNGGKYCEG |
650:
KRVRYRSCNL | EDCPDNNGKT | FREEQCEAHN | EFSKASFGSG | PAVEWIPKYA |
700:
GVSPKDRCKL | ICQAKGIGYF | FVLQPKVVDG | TPCSPDSTSV | CVQGQCVKAG |
750:
CDRIIDSKKK | FDKCGVCGGN | GSTCKKISGS | VTSAKPGYHD | IITIPTGATN |
800:
IEVKQRNQRG | SRNNGSFLAI | KAADGTYILN | GDYTLSTLEQ | DIMYKGVVLR |
850:
YSGSSAALER | IRSFSPLKEP | LTIQVLTVGN | ALRPKIKYTY | FVKKKKESFN |
900:
AIPTFSAWVI | EEWGECSKSC | ELGWQRRLVE | CRDINGQPAS | ECAKEVKPAS |
950:
TRPCADHPCP | QWQLGEWSSC | SKTCGKGYKK | RSLKCLSHDG | GVLSHESCDP |
967:
LKKPKHFIDF | CTMAECS

Vaild
Sequence:
Database Reference
Uniprot: