AURKA ELISA Kit for Bovine(Bos taurus) | EIAab.comAURKA ELISA Kit for Bovine(Bos taurus)

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AURKA (Gene name),

Aurora kinase A (Protein name ), AURKA_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AURKA(AIK;AIRK1;ARK1;AURA;AYK1;BTAK;IAK1;STK15;STK6);

Protein name:

Aurora kinase A;

Alternative:

Aurora/IPL1-related kinase 1(ARK-1;Aurora-related kinase 1);Aurora 2;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase aurora-A;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1.

Function:

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity.

Subcellular Location:

Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle pole Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles.

Protein Attributes:

Sequence length:

402

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

402:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

bta:504437

String:

Q2TA06

STRING:

9913.ENSBTAP00000042073

UniGene:

Bt.40371

SMR:

Q2TA06

Pfam:

PF00069

Uniprot:

Q2TA06

FOR

ELISA Kit for Bovine Aurora kinase A

CLIA Kit for Bovine Aurora kinase A

Polyclonal Antibody for Bovine Aurora kinase A

Monoclonal Antibody for Bovine Aurora kinase A

Protein for Bovine Aurora kinase A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Aurora-A kinase in bovine oocytes and preimplantation embryos."
Uzbekova S. , Uzbekov R. , Dalbies-Tran R. , Dupont J. , Mermillod P.
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Crossbred X Angus.
tissue: Liver.

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