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Index > Protein center > AVIL(Gene name) > Human
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  • AVIL (Gene name),
  • Advillin (Protein name ),  AVIL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    AVIL;
    Protein name:
    Advillin;
    Alternative:
    p92;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates (via C-terminus) with actin. Interacts with SCARF1 (By similarity). Interacts with F-actin.
    Function:
    Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell projection Cell projection axon
    Protein Attributes:
    Sequence length:
    819
    Sequence:
    50:
    MPLTSAFRAV | DNDPGIIVWR | IEKMELALVP | VSAHGNFYEG | DCYVILSTRR | 
    100:
    VASLLSQDIH | FWIGKDSSQD | EQSCAAIYTT | QLDDYLGGSP | VQHREVQYHE | 
    150:
    SDTFRGYFKQ | GIIYKQGGVA | SGMKHVETNT | YDVKRLLHVK | GKRNIRATEV | 
    200:
    EMSWDSFNRG | DVFLLDLGKV | IIQWNGPESN | SGERLKAMLL | AKDIRDRERG | 
    250:
    GRAKIGVIEG | DKEAASPELM | KVLQDTLGRR | SIIKPTVPDE | IIDQKQKSTI | 
    300:
    MLYHISDSAG | QLAVTEVATR | PLVQDLLNHD | DCYILDQSGT | KIYVWKGKGA | 
    350:
    TKAEKQAAMS | KALGFIKMKS | YPSSTNVETV | NDGAESAMFK | QLFQKWSVKD | 
    400:
    QTMGLGKTFS | IGKIAKVFQD | KFDVTLLHTK | PEVAAQERMV | DDGNGKVEVW | 
    450:
    RIENLELVPV | EYQWYGFFYG | GDCYLVLYTY | EVNGKPHHIL | YIWQGRHASQ | 
    500:
    DELAASAYQA | VEVDRQFDGA | AVQVRVRMGT | EPRHFMAIFK | GKLVIFEGGT | 
    550:
    SRKGNAEPDP | PVRLFQIHGN | DKSNTKAVEV | PAFASSLNSN | DVFLLRTQAE | 
    600:
    HYLWYGKGSS | GDERAMAKEL | ASLLCDGSEN | TVAEGQEPAE | FWDLLGGKTP | 
    650:
    YANDKRLQQE | ILDVQSRLFE | CSNKTGQFVV | TEITDFTQDD | LNPTDVMLLD | 
    700:
    TWDQVFLWIG | AEANATEKES | ALATAQQYLH | THPSGRDPDT | PILIIKQGFE | 
    750:
    PPIFTGWFLA | WDPNIWSAGK | TYEQLKEELG | DAAAIMRITA | DMKNATLSLN | 
    800:
    SNDSEPKYYP | IAVLLKNQNQ | ELPEDVNPAK | KENYLSEQDF | VSVFGITRGQ | 
    819:
    FAALPGWKQL | QMKKEKGLF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Advillin
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    E12414h
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    96T
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    ELISA Kit for Human Advillin
    Cat.:
    E12414m
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    96T
    ELISA Kit for Human Advillin
    Cat.:
    E12414r
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    Packing:
    96T
    CLIA Kit for Human Advillin
    Cat.:
    U12414m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Advillin
    Cat.:
    U12414r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Advillin
    Cat.:
    U12414h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Advillin
    Cat.:
    P12414Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Advillin
    Cat.:
    P12414Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Advillin
    Cat.:
    P12414Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Advillin
    Monoclonal Antibody for Human Advillin
    Monoclonal Antibody for Human Advillin
    Protein for Human Advillin
    Protein for Human Advillin
    Protein for Human Advillin

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    References
    1. 1.
      "Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins."
      Marks P.W. , Arai M. , Bandura J.L. , Kwiatkowski D.J.
      J. Cell Sci.111:2129-2136(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-204
      tissue: Uterus.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-204
      tissue: Brain.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-204
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLU-204
    6. 6.
      "Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2)."
      Tumer Z. , Croucher P.J. , Jensen L.R. , Hampe J. , Hansen C. , Kalscheuer V. , Ropers H.H. , Tommerup N. , Schreiber S.
      Gene288:179-185(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      "Functional genomic screen for modulators of ciliogenesis and cilium length."
      Kim J. , Lee J.E. , Heynen-Genel S. , Suyama E. , Ono K. , Lee K. , Ideker T. , Aza-Blanc P. , Gleeson J.G.
      Nature464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements."
      Vermeulen W. , Vanhaesebrouck P. , Van Troys M. , Verschueren M. , Fant F. , Goethals M. , Ampe C. , Martins J.C. , Borremans F.A.
      Protein Sci.13:1276-1287(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 784-819;INTERACTION WITH F-ACTIN;MUTAGENESIS OF TRP-62
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