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Index > Protein center > Acot7(Gene name) > Mouse
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  • Acot7 (Gene name),
  • Cytosolic acyl coenzyme A thioester hydrolase (Protein name ),  BACH_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Acot7(Bach);
    Protein name:
    Cytosolic acyl coenzyme A thioester hydrolase;
    Alternative:
    Brain acyl-CoA hydrolase(BACH);Acyl-CoA thioesterase 7;Long chain acyl-CoA thioester hydrolase;CTE-IIa(CTE-II);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homohexamer.
    Function:
    Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
    Subcellular Location:
    Isoform D Cytoplasm
    Protein Attributes:
    Sequence length:
    381
    Sequence:
    50:
    MKLLVGTLRL | WEVGRQVAFS | SLTPGQECSG | LRKTFWAAMR | AVRTRADHQK | 
    100:
    LGHCVTMGRI | MRPDDANVAG | NVHGGTILKM | IEEAGAIIST | RHCNSQNGER | 
    150:
    CVAALARVER | TDFLSPMCIG | EVAHVSAEIT | YTSKHSVEVQ | VHVMSENILT | 
    200:
    GTKKLTNKAT | LWYVPLSLKN | VDKVLEVPPI | VYLRQEQEEE | GRKRYEAQKL | 
    250:
    ERMETKWRNG | DIVQPVLNPE | PNTVSYSQSS | LIHLVGPSDC | TLHGFVHGGV | 
    300:
    TMKLMDEVAG | IVAARHCKTN | IVTASVDAIN | FHDKIRKGCV | ITISGRMTFT | 
    350:
    SNKSMEIEVL | VDADPVVDNS | QKRYRAASAF | FTYVSLNQEG | KPMPVPQLVP | 
    381:
    ETEDEKKRFE | EGKGRYLQMK | AKRQGHTEPQ | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    E14518r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    E14518h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    E14518m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    U14518m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    U14518h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    U14518r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    P14518Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    P14518Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    P14518Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Monoclonal Antibody for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Monoclonal Antibody for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Protein for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Protein for Mouse Cytosolic acyl coenzyme A thioester hydrolase
    Protein for Mouse Cytosolic acyl coenzyme A thioester hydrolase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human brain acyl-CoA hydrolase isoforms encoded by a single gene."
      Yamada J. , Kuramochi Y. , Takagi M. , Watanabe T. , Suga T.
      Biochem. Biophys. Res. Commun.299:49-56(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C)
      strain: ICR.
      tissue: Brain.
    2. 2.
      "Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization."
      Kuramochi Y. , Takagi-Sakuma M. , Kitahara M. , Emori R. , Asaba Y. , Sakaguchi R. , Watanabe T. , Kuroda J. , Hiratsuka K. , Nagae Y. , Suga T. , Yamada J.
      Brain Res. Mol. Brain Res.98:81-92(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);FUNCTION;TISSUE SPECIFICITY;ALTERNATIVE SPLICING
      strain: ICR.
      tissue: Brain.
    3. 3.
      "A 50-kDa isoform of mouse brain acyl-CoA hydrolase: expression and molecular properties."
      Takagi M. , Kawabe K. , Suga T. , Yamada J.
      Arch. Biochem. Biophys.429:100-105(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D);BIOPHYSICOCHEMICAL PROPERTIES;SUBCELLULAR LOCATION
      strain: ICR.
      tissue: Brain.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
      strain: C57BL/6J.
      tissue: Bone marrow.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
      tissue: Colon.
    7. 7.
      Lubec G. , Klug S. , Yang J.W. , Zigmond M.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 174-184 AND 269-284;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Hippocampus.
    8. 8.
      "Expression of acyl-CoA hydrolase in the developing mouse brain."
      Yamada J. , Kuramochi Y. , Takagi M. , Suga T.
      Neurosci. Lett.355:89-92(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    9. 9.
      "Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation."
      Forwood J.K. , Thakur A.S. , Guncar G. , Marfori M. , Mouradov D. , Meng W. , Robinson J. , Huber T. , Kellie S. , Martin J.L. , Hume D.A. , Kobe B.
      Proc. Natl. Acad. Sci. U.S.A.104:10382-10387(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 203-381;X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 59-206 (ISOFORM A);SUBUNIT;INDUCTION;MUTAGENESIS OF ASN-67 AND ASP-256;ACTIVE SITE
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