BAD ELISA Kit for Human(Homo sapiens) | EIAab.comBAD ELISA Kit for Human(Homo sapiens) | EIAab.com

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BAD (Gene name),

Bcl2 antagonist of cell death (Protein name ), BAD_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

BAD(BBC6;BCL2L8);

Protein name:

Bcl2 antagonist of cell death(BAD);

Alternative:

Bcl-2-like protein 8(Bcl2-L-8);Bcl-2-binding component 6;Bcl-XL/Bcl-2-associated death promoter;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with PIM3.

Function:

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Subcellular Location:

Mitochondrion outer membrane Cytoplasm Upon phosphorylation, locates to the cytoplasm.

Protein Attributes:

Sequence length:

168

Sequence:

50:

MFQIPEFEPS | EQEDSSSAER | GLGPSPAGDG | PSGSGKHHRQ | APGLLWDASH |

100:

QQEQPTSSSH | HGGAGAVEIR | SRHSSYPAGT | EDDEGMGEEP | SPFRGRSRSA |

150:

PPNLWAAQRY | GRELRRMSDE | FVDSFKKGLP | RPKSAGTATQ | MRQSSSWTRV |

168:

FQSWWDRNLG | RGSSAPSQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Pfam:

STRING:

9606.ENSP00000309103

String:

KEGG:

MIM:

SMR:

Uniprot:

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ELISA Kit for Human BAD

Cat.:

E15040h

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96T

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ELISA Kit for Human BAD

MSDS:

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ELISA Kit for Human BAD

Cat.:

E15040m

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96T

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CLIA Kit for Human BAD

MSDS:

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CLIA Kit for Human BAD

MSDS:

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CLIA Kit for Human BAD

Cat.:

U15040h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human BAD

Polyclonal Antibody for Human BAD

Polyclonal Antibody for Human BAD

Monoclonal Antibody for Human BAD

Monoclonal Antibody for Human BAD

Monoclonal Antibody for Human BAD

Protein for Human BAD

Protein for Human BAD

Protein for Human BAD

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A human protein that interacts with Bcl-2 and have homology to mouse BAD."
Yin D.X. , Li Z. , Huang B. , Chen S. , Zhou H.
Submitted (1996-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Bcl-2 targets the protein kinase Raf-1 to mitochondria."
Wang H.-G. , Rapp U.R. , Reed J.C.
Cell87:629-638(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PHOSPHORYLATION BY RAF-1
3.

Takayama S. , Reed J.C.
Submitted (1997-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins."
Ottilie S. , Diaz J.-L. , Horne W. , Chang J. , Wang Y. , Wilson G. , Chang S. , Weeks S. , Fritz L.C. , Oltersdorf T.
J. Biol. Chem.272:30866-30872(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DIMERIZATION
tissue: Bone marrow.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Skeletal muscle.
6.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
11.

"Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage."
Koh H. , Lee K.H. , Kim D. , Kim S. , Kim J.W. , Chung J.
J. Biol. Chem.275:34451-34458(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKT1;PHOSPHORYLATION AT SER-99
12.

"The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis."
Gnesutta N. , Qu J. , Minden A.
J. Biol. Chem.276:14414-14419(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-75
13.

"p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD."
Cotteret S. , Jaffer Z.M. , Beeser A. , Chernoff J.
Mol. Cell. Biol.23:5526-5539(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-75
14.

"Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines."
Li Y.Y. , Popivanova B.K. , Nagai Y. , Ishikura H. , Fujii C. , Mukaida N.
Cancer Res.66:6741-6747(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-75
15.

"Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis."
Popivanova B.K. , Li Y.Y. , Zheng H. , Omura K. , Fujii C. , Tsuneyama K. , Mukaida N.
Cancer Sci.98:321-328(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIM3
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91 AND SER-118;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
18.

"Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt."
Sakamaki J. , Daitoku H. , Ueno K. , Hagiwara A. , Yamagata K. , Fukamizu A.
Proc. Natl. Acad. Sci. U.S.A.108:6085-6090(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT ARG-94 AND ARG-96 BY PRMT1;MUTAGENESIS OF ARG-94 AND ARG-96
19.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies."
Petros A.M. , Nettesheim D.G. , Wang Y. , Olejniczak E.T. , Meadows R.P. , Mack J. , Swift K. , Matayoshi E.D. , Zhang H. , Thompson C.B. , Fesik S.W.
Protein Sci.9:2528-2534(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 103-127

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