BAP1 ELISA Kit for Bovine(Bos taurus) | EIAab.comBAP1 ELISA Kit for Bovine(Bos taurus)

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BAP1 (Gene name),

Ubiquitin carboxyl-terminal hydrolase BAP1 (Protein name ), BAP1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BAP1;

Protein name:

Ubiquitin carboxyl-terminal hydrolase BAP1;

Alternative:

BRCA1-associated protein 1;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1.

Function:

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor.

Subcellular Location:

Cytoplasm Nucleus Mainly nuclear. Binds to chromatin.

Protein Attributes:

Sequence length:

711

Sequence:

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711:

KRSRPYKAKR | Q

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Bt.20209

KEGG:

bta:100124510

Pfam:

PF01088

Uniprot:

A2VDM8

FOR

ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase BAP1

CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase BAP1

Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase BAP1

Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase BAP1

Protein for Bovine Ubiquitin carboxyl-terminal hydrolase BAP1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2007-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Hereford.
tissue: Basal ganglia.

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