Gene name:
BCL11B (CTIP2;RIT1) ;
Protein name:
B-cell lymphoma/leukemia 11B (BCL-11B) ;
Alternative:
COUP-TF-interacting protein 2 ;B-cell CLL/lymphoma 11B ;Radiation-induced tumor suppressor gene 1 protein (hRit1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.
Function:
Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSRRKQGNPQ | HLSQRELITP | EADHVEAAIL | EEDEGLEIEE | PSGLGLMVGG |
100:
PDPDLLTCGQ | CQMNFPLGDI | LVFIEHKRKQ | CGGSLGACYD | KALDKDSPPP |
150:
SSRSELRKVS | EPVEIGIQVT | PDEDDHLLSP | TKGICPKQEN | IAGPCRPAQL |
200:
PAVAPIAASS | HPHSSVITSP | LRALGALPPC | LPLPCCSARP | VSGDGTQGEG |
250:
QTEAPFGCQC | QLSGKDEPSS | YICTTCKQPF | NSAWFLLQHA | QNTHGFRIYL |
300:
EPGPASSSLT | PRLTIPPPLG | PEAVAQSPLM | NFLGDSNPFN | LLRMTGPILR |
350:
DHPGFGEGRL | PGTPPLFSPP | PRHHLDPHRL | SAEEMGLVAQ | HPSAFDRVMR |
400:
LNPMAIDSPA | MDFSRRLREL | AGNSSTPPPV | SPGRGNPMHR | LLNPFQPSPK |
450:
SPFLSTPPLP | PMPPGGTPPP | QPPAKSKSCE | FCGKTFKFQS | NLIVHRRSHT |
500:
GEKPYKCQLC | DHACSQASKL | KRHMKTHMHK | AGSLAGRSDD | GLSAASSPEP |
550:
GTSELAGEGL | KAADGDFRHH | ESDPSLGHEP | EEEDEEEEEE | EEELLLENES |
600:
RPESSFSMDS | ELSRNRENGG | GGVPGVPGAG | GGAAKALADE | KALVLGKVME |
650:
NVGLGALPQY | GELLADKQKR | GAFLKRAAGG | GDAGDDDDAG | GCGDAGAGGA |
700:
VNGRGGGFAP | GTEPFPGLFP | RKPAPLPSPG | LNSAAKRIKV | EKDLELPPAA |
750:
LIPSENVYSQ | WLVGYAASRH | FMKDPFLGFT | DARQSPFATS | SEHSSENGSL |
800:
RFSTPPGDLL | DGGLSGRSGT | ASGGSTPHLG | GPGPGRPSSK | EGRRSDTCEY |
850:
CGKVFKNCSN | LTVHRRSHTG | ERPYKCELCN | YACAQSSKLT | RHMKTHGQIG |
894:
KEVYRCDICQ | MPFSVYSTLE | KHMKKWHGEH | LLTNDVKIEQ | AERS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human BCL-11B
ELISA Kit for Human BCL-11B
CLIA Kit for Human BCL-11B
CLIA Kit for Human BCL-11B
Polyclonal Antibody for Human BCL-11B
Polyclonal Antibody for Human BCL-11B
Monoclonal Antibody for Human BCL-11B
Monoclonal Antibody for Human BCL-11B
Protein for Human BCL-11B
Protein for Human BCL-11B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Thymus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; THR-120; SER-256; THR-260; SER-277; SER-358; THR-376; SER-381; SER-398; THR-417; SER-483; SER-488; SER-496; SER-497; SER-678 AND SER-765;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-851;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Science314:268-274(2006)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] PRO-331
6.
"Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
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Arch. Neurol.68:587-593(2011)
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Cited for : VARIANTS VAL-32 AND SER-229