BECN1 ELISA Kit for Human(Homo sapiens) | EIAab.comBECN1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > BECN1(Gene name) > Human

BECN1 (Gene name),

Beclin-1 (Protein name ), BECN1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

BECN1(GT197);

Protein name:

Beclin-1;

Alternative:

Protein GT197;Coiled-coil myosin-like BCL2-interacting protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 upregulates autophagy, while the one containing Rubicon downregulates autophagy (By similarity). Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB.

Function:

Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Subcellular Location:

Golgi apparatus trans-Golgi network membrane Peripheral membrane protein Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

Protein Attributes:

Sequence length:

450

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.716464

String:

Q14457

STRING:

9606.ENSP00000355231

KEGG:

hsa:8678

SMR:

Q14457

Pfam:

PF04111

MIM:

604378

Uniprot:

Q14457

FOR

ELISA Kit for Human Beclin-1

Cat.:

E1025h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Beclin-1

Cat.:

E1025m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Beclin-1

Cat.:

E1025r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Beclin-1

Cat.:

E1025p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Beclin-1

Cat.:

E1025b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Beclin-1

Cat.:

E1025c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Beclin-1

Cat.:

U1025b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Beclin-1

Cat.:

U1025c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Beclin-1

Cat.:

U1025p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Beclin-1

Cat.:

U1025r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Beclin-1

Cat.:

U1025m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Beclin-1

Cat.:

U1025h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human Beclin-1

Cat.:

P1025Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Beclin-1

Cat.:

P1025Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Beclin-1

Cat.:

P1025Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Beclin-1

Protein for Human Beclin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein."
Liang X.H. , Kleeman L.K. , Jiang H.H. , Gordon G. , Goldman J.E. , Berry G. , Herman B. , Levine B.
J. Virol.72:8586-8596(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH BCL-2
tissue: Brain.
2.

"Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21."
Aita V.M. , Liang X.H. , Murty V.V.V.S. , Pincus D.L. , Yu W. , Cayanis E. , Kalachikov S. , Gilliam T.C. , Levine B.
Genomics59:59-65(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Liver.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Cervix.
5.

"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21."
Rommens J.M. , Durocher F. , McArthur J. , Tonin P. , Leblanc J.-F. , Allen T. , Samson C. , Ferri L. , Narod S. , Morgan K. , Simard J.
Genomics28:530-542(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-450
tissue: Mammary gland.
6.

"Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG."
Itakura E. , Kishi C. , Inoue K. , Mizushima N.
Mol. Biol. Cell19:5360-5372(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG14; PIK3C3; PIK3R4 AND UVRAG
7.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells."
Sauermann M. , Sahin O. , Sultmann H. , Hahne F. , Blaszkiewicz S. , Majety M. , Zatloukal K. , Fuzesi L. , Poustka A. , Wiemann S. , Arlt D.
Oncogene27:1320-1326(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VMP1
9.

"Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase."
Sun Q. , Fan W. , Chen K. , Ding X. , Chen S. , Zhong Q.
Proc. Natl. Acad. Sci. U.S.A.105:19211-19216(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG14; PIK3C3 AND UVRAG;SUBCELLULAR LOCATION
10.

"DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy."
Zalckvar E. , Berissi H. , Mizrachy L. , Idelchuk Y. , Koren I. , Eisenstein M. , Sabanay H. , Pinkas-Kramarski R. , Kimchi A.
EMBO Rep.10:285-292(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-119;INTERACTION WITH DAPK1
11.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."
Matsunaga K. , Saitoh T. , Tabata K. , Omori H. , Satoh T. , Kurotori N. , Maejima I. , Shirahama-Noda K. , Ichimura T. , Isobe T. , Akira S. , Noda T. , Yoshimori T.
Nat. Cell Biol.11:385-396(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG14; KIAA0226; PIK3C3; PIK3R4 AND UVRAG
13.

"PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."
Sagona A.P. , Nezis I.P. , Pedersen N.M. , Liestol K. , Poulton J. , Rusten T.E. , Skotheim R.I. , Raiborg C. , Stenmark H.
Nat. Cell Biol.12:362-371(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13."
Liu J. , Xia H. , Kim M. , Xu L. , Li Y. , Zhang L. , Cai Y. , Norberg H.V. , Zhang T. , Furuya T. , Jin M. , Zhu Z. , Wang H. , Yu J. , Li Y. , Hao Y. , Choi A. , Ke H. , more...
Cell147:223-234(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH USP10 AND USP13
15.

"Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1."
Platta H.W. , Abrahamsen H. , Thoresen S.B. , Stenmark H.
Biochem. J.441:399-406(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY NEDD4;MUTAGENESIS OF TYR-352
16.

"The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1."
Chaumorcel M. , Lussignol M. , Mouna L. , Cavignac Y. , Fahie K. , Cotte-Laffitte J. , Geballe A. , Brune W. , Beau I. , Codogno P. , Esclatine A.
J. Virol.86:2571-2584(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN TRS1
17.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein."
Oberstein A. , Jeffrey P.D. , Shi Y.
J. Biol. Chem.282:13123-13132(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 107-135 IN COMPLEX WITH BCL2L1;DOMAIN BH3 MOTIF
19.

"Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin-1."
Feng W. , Huang S. , Wu H. , Zhang M.
J. Mol. Biol.372:223-235(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 106-128 IN COMPLEX WITH BCL2L1

Product Feedback Wall

* Email:
*Comments: