BIRC2 ELISA Kit for Human(Homo sapiens) | EIAab.comBIRC2 ELISA Kit for Human(Homo sapiens)

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BIRC2 (Gene name),

Baculoviral IAP repeat-containing protein 2 (Protein name ), BIRC2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BIRC2(API1;IAP2;MIHB;RNF48);

Protein name:

Baculoviral IAP repeat-containing protein 2;

Alternative:

IAP homolog B;C-IAP1;RING finger protein 48;Inhibitor of apoptosis protein 2(IAP-2;hIAP-2;hIAP2);TNFR2-TRAF-signaling complex protein 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9.

Function:

Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

618

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

618:

KCPICRGIIK | GTVRTFLS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000227758

String:

Q13490

MIM:

601712

UniGene:

Hs.696238

Pfam:

PF00653

SMR:

Q13490

KEGG:

hsa:329

Uniprot:

Q13490

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ELISA Kit for Human Baculoviral IAP repeat-containing protein 2

Cat.:

E10854h

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96T

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ELISA Kit for Human Baculoviral IAP repeat-containing protein 2

Cat.:

E10854m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Baculoviral IAP repeat-containing protein 2

Cat.:

U10854m

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MSDS:

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Packing:

96T

CLIA Kit for Human Baculoviral IAP repeat-containing protein 2

Cat.:

U10854h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Baculoviral IAP repeat-containing protein 2

Cat.:

P10854Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Baculoviral IAP repeat-containing protein 2

Protein for Human Baculoviral IAP repeat-containing protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤5.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤8.4%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of BIRC2 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	95	91-101
Plasma	97	93-104

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of BIRC2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-99%	90-102%	91-101%	88-103%
EDTA plasma(n=5)	90-105%	89-107%	92-101%	95-99%
heparin plasma(n=5)	93-100%	94-102%	91-103%	91-105%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins."
Rothe M. , Pan M.-G. , Henzel W.J. , Ayres T.M. , Goeddel D.V.
Cell83:1243-1252(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes."
Liston P. , Roy N. , Tamai K. , Lefebvre C. , Baird S. , Cherton-Horvat G. , Farahani R. , McLean M. , Ikeda J. , Mackenzie A. , Korneluk R.G.
Nature379:349-353(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
3.

"Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors."
Uren A.G. , Pakusch M. , Hawkins C.J. , Puls K.L. , Vaux D.L.
Proc. Natl. Acad. Sci. U.S.A.93:4974-4978(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal liver.
4.

NIEHS SNPs program
Submitted (2005-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-453; VAL-506 AND SER-549
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Thymus.
6.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
tissue: Uterus.
8.

"cIAP1 Localizes to the nuclear compartment and modulates the cell cycle."
Samuel T. , Okada K. , Hyer M. , Welsh K. , Zapata J.M. , Reed J.C.
Cancer Res.65:210-218(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BIRC5/SURVIVIN
9.

"c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1."
Xu L. , Zhu J. , Hu X. , Zhu H. , Kim H.T. , LaBaer J. , Goldberg A. , Yuan J.
Mol. Cell28:914-922(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE UBIQUITINATION OF MXD1/MAD1
10.

"IAPs: more than just inhibitors of apoptosis proteins."
Dubrez-Daloz L. , Dupoux A. , Cartier J.
Cell Cycle7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
13.

"To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death."
Lopez J. , Meier P.
Curr. Opin. Cell Biol.22:872-881(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
14.

"Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."
Broemer M. , Tenev T. , Rigbolt K.T. , Hempel S. , Blagoev B. , Silke J. , Ditzel M. , Meier P.
Mol. Cell40:810-822(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE OF THE NEDD8 CONJUGATION PATHWAY
15.

"IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer."
Gyrd-Hansen M. , Meier P.
Nat. Rev. Cancer10:561-574(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
16.

"Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity."
Damgaard R.B. , Gyrd-Hansen M.
Discov. Med.11:221-231(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
17.

"Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription."
Cartier J. , Berthelet J. , Marivin A. , Gemble S. , Edmond V. , Plenchette S. , Lagrange B. , Hammann A. , Dupoux A. , Delva L. , Eymin B. , Solary E. , Dubrez L.
J. Biol. Chem.286:26406-26417(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH E2F1 AND TRAF2;SUBCELLULAR LOCATION
18.

"The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2."
Mei Y. , Hahn A.A. , Hu S. , Yang X.
J. Biol. Chem.286:35380-35387(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;INTERACTION WITH USP19
19.

"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."
Bertrand M.J. , Lippens S. , Staes A. , Gilbert B. , Roelandt R. , De Medts J. , Gevaert K. , Declercq W. , Vandenabeele P.
PLoS ONE6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE UBIQUITINATION OF RIPK1; RIPK2; RIPK3 AND RIPK4;INTERACTION WITH RIPK1; RIPK2; RIPK3 AND RIPK4
20.

"IAPs: guardians of RIPK1."
Darding M. , Meier P.
Cell Death Differ.19:58-66(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
21.

"IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."
Zhou A.Y. , Shen R.R. , Kim E. , Lock Y.J. , Xu M. , Chen Z.J. , Hahn W.C.
Cell Rep.3:724-733(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IKBKE UBIQUITINATION
22.

"Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat."
Hinds M.G. , Norton R.S. , Vaux D.L. , Day C.L.
Nat. Struct. Biol.6:648-651(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 266-363
23.

"The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9."
Kulathila R. , Vash B. , Sage D. , Cornell-Kennon S. , Wright K. , Koehn J. , Stams T. , Clark K. , Price A.
Acta Crystallogr. D65:58-66(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 260-352 IN COMPLEXES WITH ZINC IONS; DIABLO AND CASP9 PEPTIDES;SUBUNIT
24.

"CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration."
Lopez J. , John S.W. , Tenev T. , Rautureau G.J. , Hinds M.G. , Francalanci F. , Wilson R. , Broemer M. , Santoro M.M. , Day C.L. , Meier P.
Mol. Cell42:569-583(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 435-562;DOMAIN CARD;ENZYME REGULATION

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