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Index > Protein center > BMP7(Gene name) > Human
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  • BMP7 (Gene name),
  • Bone morphogenetic protein 7 (Protein name ),  BMP7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    BMP7(OP1);
    Protein name:
    Bone morphogenetic protein 7(BMP-7);
    Alternative:
    Osteogenic protein 1(OP-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.
    Function:
    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    431
    Sequence:
    50:
    MHVRSLRAAA | PHSFVALWAP | LFLLRSALAD | FSLDNEVHSS | FIHRRLRSQE | 
    100:
    RREMQREILS | ILGLPHRPRP | HLQGKHNSAP | MFMLDLYNAM | AVEEGGGPGG | 
    150:
    QGFSYPYKAV | FSTQGPPLAS | LQDSHFLTDA | DMVMSFVNLV | EHDKEFFHPR | 
    200:
    YHHREFRFDL | SKIPEGEAVT | AAEFRIYKDY | IRERFDNETF | RISVYQVLQE | 
    250:
    HLGRESDLFL | LDSRTLWASE | EGWLVFDITA | TSNHWVVNPR | HNLGLQLSVE | 
    300:
    TLDGQSINPK | LAGLIGRHGP | QNKQPFMVAF | FKATEVHFRS | IRSTGSKQRS | 
    350:
    QNRSKTPKNQ | EALRMANVAE | NSSSDQRQAC | KKHELYVSFR | DLGWQDWIIA | 
    400:
    PEGYAAYYCE | GECAFPLNSY | MNATNHAIVQ | TLVHFINPET | VPKPCCAPTQ | 
    431:
    LNAISVLYFD | DSSNVILKKY | RNMVVRACGC | H
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human BMP-7
    Cat.:
    E0799m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human BMP-7
    Cat.:
    E0799h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human BMP-7
    MSDS:
    Please sign in first.
    CLIA Kit for Human BMP-7
    MSDS:
    Please sign in first.
    CLIA Kit for Human BMP-7
    Cat.:
    U0799m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human BMP-7
    Cat.:
    U0799h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human BMP-7
    Cat.:
    P0799Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human BMP-7
    Polyclonal Antibody for Human BMP-7
    Cat.:
    P0799Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human BMP-7
    Monoclonal Antibody for Human BMP-7
    Monoclonal Antibody for Human BMP-7
    Protein for Human BMP-7
    Protein for Human BMP-7
    Cat.:
    R0799h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human BMP-7
    Cat.:
    R0799m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

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    References
    1. 1.
      "OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."
      Oezkaynak E. , Rueger D.C. , Drier E.A. , Corbett C. , Ridge R.J. , Sampath T.K. , Oppermann H.
      EMBO J.9:2085-2093(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Placenta.
    2. 2.
      "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
      Celeste A.J. , Iannazzi J.A. , Taylor R.C. , Hewick R.M. , Rosen V. , Wang E.A. , Wozney J.M.
      Proc. Natl. Acad. Sci. U.S.A.87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "Expression and characterization of a human BMP-7 variant with improved biochemical properties."
      Swencki-Underwood B. , Mills J.K. , Vennarini J. , Boakye K. , Luo J. , Pomerantz S. , Cunningham M.R. , Farrell F.X. , Naso M.F. , Amegadzie B.
      Protein Expr. Purif.57:312-319(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 293-302
    6. 6.
      "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."
      Yanagita M. , Oka M. , Watabe T. , Iguchi H. , Niida A. , Takahashi S. , Akiyama T. , Miyazono K. , Yanagisawa M. , Sakurai T.
      Biochem. Biophys. Res. Commun.316:490-500(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOSTDC1
    7. 7.
      "Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."
      Wyatt A.W. , Osborne R.J. , Stewart H. , Ragge N.K.
      Hum. Mutat.31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;VARIANTS PRO-198 AND SER-321;ASSOCIATION WITH DEVELOPMENTAL EYE ANOMALIES
    8. 8.
      "Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."
      Griffith D.L. , Keck P.C. , Sampath T.K. , Rueger D.C. , Carlson W.D.
      Proc. Natl. Acad. Sci. U.S.A.93:878-883(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 293-431
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