BRCA2 ELISA Kit for Human(Homo sapiens) | EIAab.comBRCA2 ELISA Kit for Human(Homo sapiens)

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BRCA2 (Gene name),

Breast cancer type 2 susceptibility protein (Protein name ), BRCA2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

BRCA2(FACD;FANCD1);

Protein name:

Breast cancer type 2 susceptibility protein;

Alternative:

Fanconi anemia group D1 protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer and dimer. Interacts with RAD51 and DSS1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Interacts with WDR16. Interacts with USP11. Interacts with DMC1. Part of a trimeric complex containing BRCA1, BRCA2 and PALB2. Interacts with PALB2. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with ROCK2 and NPM1.

Function:

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

3418

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3418:

TEECEKNKQD | TITTKKYI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P51587

KEGG:

hsa:675

UniGene:

Hs.34012

SMR:

P51587

MIM:

114480

STRING:

9606.ENSP00000369497

Pfam:

PF09169

Uniprot:

P51587

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ELISA Kit for Human Breast cancer type 2 susceptibility protein

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E1364h

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96T

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ELISA Kit for Human Breast cancer type 2 susceptibility protein

Cat.:

E1364m

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MSDS:

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Packing:

96T

ELISA Kit for Human Breast cancer type 2 susceptibility protein

Cat.:

E1364r

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MSDS:

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96T

CLIA Kit for Human Breast cancer type 2 susceptibility protein

Cat.:

U1364h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Breast cancer type 2 susceptibility protein

Cat.:

U1364r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Breast cancer type 2 susceptibility protein

Cat.:

U1364m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Breast cancer type 2 susceptibility protein

Cat.:

P1364Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Breast cancer type 2 susceptibility protein

Cat.:

P1364Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Breast cancer type 2 susceptibility protein

Cat.:

P1364Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Breast cancer type 2 susceptibility protein

Protein for Human Breast cancer type 2 susceptibility protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of the breast cancer susceptibility gene BRCA2."
Wooster R. , Bignell G. , Lancaster J. , Swift S. , Seal S. , Mangion J. , Collins N. , Gregory S. , Gumbs C. , Micklem G. , Barfoot R. , Hamoudi R. , Patel S. , Rice C. , Biggs P. , Hashim Y. , Smith A. , Connor F. , more...
Nature378:789-792(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds."
Tavtigian S.V. , Simard J. , Rommens J. , Couch F. , Shattuck-Eidens D. , Neuhausen S. , Merajver S. , Thorlacius S. , Offit K. , Stoppa-Lyonnet D. , Belanger C. , Bell R. , Berry S. , Bogden R. , Chen Q. , Davis T. , Dumont M. , Frye C. , more...
Nat. Genet.12:333-337(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PHE-599
3.

NIEHS SNPs program
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-289; GLN-322; ASN-372; VAL-784; SER-929; PHE-976; ILE-987; ASP-991; ASN-1561; LYS-1880; MET-1915; PHE-2138; ARG-2162; ARG-2440; VAL-2466; THR-2490; PRO-2835; ALA-2856; PHE-2944; THR-2951; ILE-3244 AND VAL-3412
4.

"The DNA sequence and analysis of human chromosome 13."
Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS ASN-372 AND VAL-2466
5.

"Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients."
Ozcelik H. , Schmocker B. , Di Nicola N. , Shi X.H. , Langer B. , Moore M. , Taylor B.R. , Narod S.A. , Darlington G. , Andrulis I.L. , Gallinger S. , Redston M.
Nat. Genet.16:17-18(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PNCA2
6.

"Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways."
Hussain S. , Wilson J.B. , Medhurst A.L. , Hejna J. , Witt E. , Ananth S. , Davies A. , Masson J.-Y. , Moses R. , West S.C. , de Winter J.P. , Ashworth A. , Jones N.J. , Mathew C.G.
Hum. Mol. Genet.13:1241-1248(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FANCD2
7.

"Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin."
Wang X.Z. , Andreassen P.R. , D'Andrea A.D.
Mol. Cell. Biol.24:5850-5862(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH FANCD2
8.

"BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage."
Schoenfeld A.R. , Apgar S. , Dolios G. , Wang R. , Aaronson S.A.
Mol. Cell. Biol.24:7444-7455(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION;INTERACTION WITH USP11
9.

"Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms tumour."
The famillial Wilms tumor collaboration , Reid S. , Renwick A. , Seal S. , Baskcomb L. , Barfoot R. , Jayatilake H. , Pritchard-Jones K. , Stratton M.R. , Ridolfi-Luethy A. , Rahman N.
J. Med. Genet.42:147-151(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN GLM3
10.

"FANCD2 functions independently of BRCA2 and RAD51 associated homologous recombination in response to DNA damage."
Ohashi A. , Zdzienicka M.Z. , Chen J. , Couch F.J.
J. Biol. Chem.280:14877-14883(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair."
Esashi F. , Christ N. , Gannon J. , Liu Y. , Hunt T. , Jasin M. , West S.C.
Nature434:598-604(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-3291 BY CDK2;INTERACTION WITH RAD51;MUTAGENESIS OF SER-3291
12.

"WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation."
Silva F.P. , Hamamoto R. , Nakamura Y. , Furukawa Y.
Neoplasia7:348-355(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WDR16
13.

"Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2."
Xia B. , Sheng Q. , Nakanishi K. , Ohashi A. , Wu J. , Christ N. , Liu X. , Jasin M. , Couch F.J. , Livingston D.M.
Mol. Cell22:719-729(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PALB2;CHARACTERIZATION OF VARIANTS BC ARG-25; CYS-31 AND ARG-31
14.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-755;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
15.

"FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3."
Wilson J.B. , Yamamoto K. , Marriott A.S. , Hussain S. , Sung P. , Hoatlin M.E. , Mathew C.G. , Takata M. , Thompson L.H. , Kupfer G.M. , Jones N.J.
Oncogene27:3641-3652(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FANCD2; FANCG AND XRCC3
16.

"The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage."
Bahassi E.M. , Ovesen J.L. , Riesenberg A.L. , Bernstein W.Z. , Hasty P.E. , Stambrook P.J.
Oncogene27:3977-3985(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RAD51-DEPENDENT DNA REPAIR;PHOSPHORYLATION AT THR-3387 BY CHEK1 AND CHEK2;MUTAGENESIS OF THR-3387;INTERACTION WITH RAD51
17.

"PALB2 is an integral component of the BRCA complex required for homologous recombination repair."
Sy S.M. , Huen M.S. , Chen J.
Proc. Natl. Acad. Sci. U.S.A.106:7155-7160(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A BRCA COMPLEX WITH BRCA1 AND PALB2
18.

"Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA."
Liu J. , Doty T. , Gibson B. , Heyer W.D.
Nat. Struct. Mol. Biol.17:1260-1262(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAD51
19.

"The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA."
Thorslund T. , McIlwraith M.J. , Compton S.A. , Lekomtsev S. , Petronczki M. , Griffith J.D. , West S.C.
Nat. Struct. Mol. Biol.17:1263-1265(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
20.

"Purified human BRCA2 stimulates RAD51-mediated recombination."
Jensen R.B. , Carreira A. , Kowalczykowski S.C.
Nature467:678-683(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH RAD51 AND DMC1
21.

"BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2."
Wang H.F. , Takenaka K. , Nakanishi A. , Miki Y.
Cancer Res.71:68-77(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ROCK2 AND NPM1
22.

"Homologous recombination proteins are associated with centrosomes and are required for mitotic stability."
Cappelli E. , Townsend S. , Griffin C. , Thacker J.
Exp. Cell Res.317:1203-1213(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
23.

"Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair."
Park J.Y. , Singh T.R. , Nassar N. , Zhang F. , Freund M. , Hanenberg H. , Meetei A.R. , Andreassen P.R.
Oncogene33:4803-4812(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PALB2;IDENTIFICATION IN A PALB2-CONTAINING HR COMPLEX
24.

"Breast cancer proteins PALB2 and BRCA2 stimulate polymerase eta in recombination-associated DNA synthesis at blocked replication forks."
Buisson R. , Niraj J. , Pauty J. , Maity R. , Zhao W. , Coulombe Y. , Sung P. , Masson J.Y.
Cell Rep.6:553-564(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH POLH
25.

"BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2."
Bhatia V. , Barroso S.I. , Garcia-Rubio M.L. , Tumini E. , Herrera-Moyano E. , Aguilera A.
Nature511:362-365(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN R-LOOP PROCESSING;INTERACTION WITH DSS1 AND PCID2
26.

"Insights into DNA recombination from the structure of a RAD51-BRCA2 complex."
Pellegrini L. , Yu D.S. , Lo T. , Anand S. , Lee M. , Blundell T.L. , Venkitaraman A.R.
Nature420:287-293(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1519-1551 IN COMPLEX WITH RAD51
27.

"Structural basis for recruitment of BRCA2 by PALB2."
Oliver A.W. , Swift S. , Lord C.J. , Ashworth A. , Pearl L.H.
EMBO Rep.10:990-996(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 21-39 IN COMPLEX WITH PALB2
28.

"Mutations of the BRCA2 gene in ovarian carcinomas."
Takahashi H. , Chiu H.-C. , Bandera C.A. , Behbakht K. , Liu P.C. , Couch F.J. , Weber B.L. , LiVolsi V.A. , Furusato M. , Rebane B.A. , Cardonick A. , Benjamin I. , Morgan M.A. , King S.A. , Mikuta J.J. , Rubin S.C. , Boyd J.
Cancer Res.56:2738-2741(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OVARIAN CANCER HIS-2787;VARIANTS ASN-372; MET-1915 AND VAL-2466
29.

"BRCA2 germline mutations in male breast cancer cases and breast cancer families."
Couch F.J. , Farid L.M. , Deshano M.L. , Tavtigian S.V. , Calzone K. , Campeau L. , Peng Y. , Bogden B. , Chen Q. , Neuhausen S. , Shattuck-Eidens D. , Godwin A.K. , Daly M. , Radford D.M. , Sedlacek S. , Rommens J. , Simard J. , Garber J. , more...
Nat. Genet.13:123-125(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-372; ASP-991; SER-1147; MET-1915 AND CYS-2034
30.

"BRCA2 mutations in primary breast and ovarian cancers."
Lancaster J.M. , Wooster R. , Mangion J. , Phelan C.M. , Cochran C. , Gumbs C. , Seal S. , Barfoot R. , Collins N. , Bignell G. , Patel S. , Hamoudi R. , Larsson C. , Wiseman R.W. , Berchuck A. , Iglehart J.D. , Marks J.R. , Ashworth A. , more...
Nat. Genet.13:238-240(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLU-3095
31.

"Low incidence of BRCA2 mutations in breast carcinoma and other cancers."
Teng D.H.-F. , Bogden R. , Mitchell J. , Baumgard M. , Bell R. , Berry S. , Davis T. , Ha P.C. , Kehrer R. , Jammulapati S. , Chen Q. , Offit K. , Skolnick M.H. , Tavtigian S.V. , Jhanwar S. , Swedlund B. , Wong A.K.C. , Kamb A.
Nat. Genet.13:241-244(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS
32.

"Mutation analysis in the BRCA2 gene in primary breast cancers."
Miki Y. , Katagiri T. , Kasumi F. , Yoshimoto T. , Nakamura Y.
Nat. Genet.13:245-247(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC ASN-2415
33.

"A low proportion of BRCA2 mutations in Finnish breast cancer families."
Vehmanen P. , Friedman L.S. , Eerola H. , Sarantaus L. , Pyrhoenen S. , Ponder B.A.J. , Muhonen T. , Nevanlinna H.
Am. J. Hum. Genet.60:1050-1058(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC ASP-2089;VARIANT VAL-3412
34.

"High throughput fluorescence-based conformation-sensitive gel electrophoresis (F-CSGE) identifies six unique BRCA2 mutations and an overall low incidence of BRCA2 mutations in high-risk BRCA1-negative breast cancer families."
Ganguly T. , Dhulipala R. , Godmilow L. , Ganguly A.
Hum. Genet.102:549-556(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC/PANCREAS CANCER TRP-554
35.

"High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families."
Katagiri T. , Kasumi F. , Yoshimoto M. , Nomizu T. , Asaishi K. , Abe R. , Tsuchiya A. , Sugano M. , Takai S. , Yoneda M. , Fukutomi T. , Nanba K. , Makita M. , Okazaki H. , Hirata K. , Okazaki M. , Furutsuma Y. , Morishita Y. , more...
J. Hum. Genet.43:42-48(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC LEU-32; ARG-53; LEU-81; ARG-201; ALA-211; SER-222 AND THR-3118
36.

"The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes."
Gayther S.A. , Russell P. , Harrington P. , Antoniou A.C. , Easton D.F. , Ponder B.A.J.
Am. J. Hum. Genet.65:1021-1029(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OVARIAN CANCER PRO-75; HIS-2502 AND HIS-3098
37.

"Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in Taiwan."
Li S.S.-L. , Tseng H.-M. , Yang T.-P. , Liu C.-H. , Teng S.-J. , Huang H.-W. , Chen L.-M. , Kao H.-W. , Chen J.H. , Tseng J.-N. , Chen A. , Hou M.-F. , Huang T.-J. , Chang H.-T. , Mok K.-T. , Tsai J.-H.
Hum. Genet.104:201-204(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-289; ASN-372; ASP-991 AND VAL-3412
38.

"Global sequence diversity of BRCA2: analysis of 71 breast cancer families and 95 control individuals of worldwide populations."
Wagner T.M.U. , Hirtenlehner K. , Shen P. , Moeslinger R. , Muhr D. , Fleischmann E. , Concin H. , Doeller W. , Haid A. , Lang A.H. , Mayer P. , Petru E. , Ropp E. , Langbauer G. , Kubista E. , Scheiner O. , Underhill P. , Mountain J. , more...
Hum. Mol. Genet.8:413-423(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC;VARIANTS
39.

"Germline brca2 sequence variants in patients with ocular melanoma."
Sinilnikova O.M. , Egan K.M. , Quinn J.L. , Boutrand L. , Lenoir G.M. , Stoppa-Lyonnet D. , Desjardins L. , Levy C. , Goldgar D. , Gragoudas E.S.
Int. J. Cancer82:325-328(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC ARG-326;VARIANT ILE-2728
40.

"A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability."
Healey C.S. , Dunning A.M. , Teare M.D. , Chase D. , Parker L. , Burn J. , Chang-Claude J. , Mannermaa A. , Kataja V. , Huntsman D.G. , Pharoah P.D.P. , Luben R.N. , Easton D.F. , Ponder B.A.J.
Nat. Genet.26:362-364(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-372
41.

"BRCA2 germline mutations among early onset breast cancer patients unselected for family history of the disease."
Plaschke J. , Commer T. , Jacobi C. , Schackert H.K. , Chang-Claude J.
J. Med. Genet.37:E17-E17(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC MET-729; ILE-2515 AND ILE-2728;VARIANTS HIS-289; ASN-372; ASP-991; MET-1915 AND VAL-3412
42.

"BRCA2 germline mutations in male breast cancer patients in the Polish population."
Kwiatkowska E. , Teresiak M. , Lamperska K.M. , Karczewska A. , Breborowicz D. , Stawicka M. , Godlewski D. , Krzyzosiak W.J. , Mackiewicz A.
Hum. Mutat.17:73-73(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC ASN-1179; ILE-3124 AND GLU-3196;VARIANT TYR-1420
43.

"An improved high throughput heteroduplex mutation detection system for screening BRCA2 mutations-fluorescent mutation detection (F-MD)."
Edwards S.M. , Kote-Jarai Z. , Hamoudi R. , Eeles R.A.
Hum. Mutat.17:220-232(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC THR-505; TYR-1730; HIS-2135 AND CYS-2222;VARIANT LYS-1880
44.

"BRCA2 T2722R is a deleterious allele that causes exon skipping."
Fackenthal J.D. , Cartegni L. , Krainer A.R. , Olopade O.I.
Am. J. Hum. Genet.71:625-631(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC ARG-2722
45.

Fackenthal J.D. , Cartegni L. , Krainer A.R. , Olopade O.I.
Am. J. Hum. Genet.73:1477-1477(2002)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
46.

"BRCA2 gene mutations in families with aggregations of breast and stomach cancers."
Jakubowska A. , Nej K. , Huzarski T. , Scott R.J. , Lubinski J.
Br. J. Cancer87:888-891(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC CYS-2072; CYS-2094 AND ASN-2128
47.

"Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%."
Murphy K.M. , Brune K.A. , Griffin C. , Sollenberger J.E. , Petersen G.M. , Bansal R. , Hruban R.H. , Kern S.E.
Cancer Res.62:3789-3793(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-192
48.

"Infrequent mutation in the BRCA2 gene in esophageal squamous cell carcinoma."
Hu N. , Li G. , Li W.-J. , Wang C. , Goldstein A.M. , Tang Z.-Z. , Roth M.J. , Dawsey S.M. , Huang J. , Wang Q.-H. , Ding T. , Giffen C. , Taylor P.R. , Emmert-Buck M.R.
Clin. Cancer Res.8:1121-1126(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-118; SER-315; ILE-1988; CYS-2842 AND SER-3300
49.

"Characterization of common BRCA1 and BRCA2 variants."
Deffenbaugh A.M. , Frank T.S. , Hoffman M. , Cannon-Albright L. , Neuhausen S.L.
Genet. Test.6:119-121(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-598; TYR-1420; CYS-2034; ILE-2728 AND THR-2951
50.

"BRCA1 and BRCA2 in Indian breast cancer patients."
Saxena S. , Szabo C.I. , Chopin S. , Barjhoux L. , Sinilnikova O. , Lenoir G. , Goldgar D.E. , Bhatanager D.
Hum. Mutat.20:473-474(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-1593 AND SER-2706
51.

"BRCA1 and BRCA2 sequence variants in Chinese breast cancer families."
Zhi X. , Szabo C. , Chopin S. , Suter N. , Wang Q.-S. , Ostrander E.A. , Sinilnikova O.M. , Lenoir G.M. , Goldgar D. , Shi Y.-R.
Hum. Mutat.20:474-474(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC ASN-2729;VARIANT VAL-3412
52.

"BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico."
Ruiz-Flores P. , Sinilnikova O.M. , Badzioch M. , Calderon-Garciduenas A.L. , Chopin S. , Fabrice O. , Gonzalez-Guerrero J.F. , Szabo C. , Lenoir G. , Goldgar D.E. , Barrera-Saldana H.A.
Hum. Mutat.20:474-475(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC CYS-42; ARG-613; LEU-2118; LEU-2293 AND ARG-2793;VARIANT ILE-3374
53.

"Somatic mutations in the BRCA2 gene and high frequency of allelic loss of BRCA2 in sporadic male breast cancer."
Kwiatkowska E. , Teresiak M. , Breborowicz D. , Mackiewicz A.
Int. J. Cancer98:943-945(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC TYR-1580 AND MET-1915
54.

"Biallelic inactivation of BRCA2 in Fanconi anemia."
Howlett N.G. , Taniguchi T. , Olson S. , Cox B. , Waisfisz Q. , de Die-Smulders C. , Persky N. , Grompe M. , Joenje H. , Pals G. , Ikeda H. , Fox E.A. , D'Andrea A.D.
Science297:606-609(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN FANCD1
55.

"BRCA2 germline mutations in Cypriot patients with familial breast/ovarian cancer."
Hadjisavvas A. , Charalambous E. , Adamou A. , Christodoulou C.G. , Kyriacou K.
Hum. Mutat.21:171-171(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-289; ASN-372; GLY-462; ASP-991; SER-1279; TYR-1420; ASP-1771 AND VAL-2466
56.

"Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families in Southern Germany."
Meyer P. , Voigtlaender T. , Bartram C.R. , Klaes R.
Hum. Mutat.22:259-259(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC ILE-431; LYS-1036; ARG-1106 AND VAL-1524
57.

"Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1and BRCA2genes in familial breast cancer."
Sakayori M. , Kawahara M. , Shiraishi K. , Nomizu T. , Shimada A. , Kudo T. , Abe R. , Ohuchi N. , Takenoshita S. , Kanamaru R. , Ishioka C.
J. Hum. Genet.48:130-137(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-582; PHE-1522 AND VAL-2044
58.

"BRCA2 germline mutations in familial pancreatic carcinoma."
Hahn S.A. , Greenhalf B. , Ellis I. , Sina-Frey M. , Rieder H. , Korte B. , Gerdes B. , Kress R. , Ziegler A. , Raeburn J.A. , Campra D. , Gruetzmann R. , Rehder H. , Rothmund M. , Schmiegel W. , Neoptolemos J.P. , Bartsch D.K.
J. Natl. Cancer Inst.95:214-221(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-2034 AND GLU-3076
59.

"Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood."
Hirsch B. , Shimamura A. , Moreau L. , Baldinger S. , Hag-alshiekh M. , Bostrom B. , Sencer S. , D'Andrea A.D.
Blood103:2554-2559(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FANCD1 PRO-2510
60.

"BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families."
Claes K. , Poppe B. , Coene I. , De Paepe A. , Messiaen L.
Br. J. Cancer90:1244-1251(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC SER-60; ARG-405; HIS-448; GLY-462; GLY-2275; ARG-2353; LYS-2488; HIS-2723; ASN-2950; ILE-3013 AND HIS-3098;VARIANTS ASP-991; ALA-2856 AND VAL-3412
61.

"Hereditary breast and ovarian cancer in Cyprus: identification of a founder BRCA2 mutation."
Hadjisavvas A. , Charalambous E. , Adamou A. , Neuhausen S.L. , Christodoulou C.G. , Kyriacou K.
Cancer Genet. Cytogenet.151:152-156(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC ILE-64; GLY-462; ASN-1690; ASP-1771; MET-1887; MET-1915 AND GLU-2456;VARIANTS HIS-289; ASN-372; ASP-991; SER-1279; TYR-1420; CYS-2108 AND VAL-2466
62.

"One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: results of a prospective study in Southern Sweden."
Malander S. , Ridderheim M. , Masbaeck A. , Loman N. , Kristoffersson U. , Olsson H. , Nilbert M. , Borg A.
Eur. J. Cancer40:422-428(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OVARIAN CANCER CYS-42;VARIANTS SER-3063 AND VAL-3412
63.

"Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families."
Valarmathi M.T. , Sawhney M. , Deo S.S.V. , Shukla N.K. , Das S.N.
Hum. Mutat.23:205-205(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC ILE-1679; ALA-1804; LYS-1901 AND LEU-2096
64.

"RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1."
Sharp A. , Pichert G. , Lucassen A. , Eccles D.
Hum. Mutat.24:272-272(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-225;CHARACTERIZATION OF VARIANT ALA-225
65.

"BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer."
Seo J.H. , Cho D.-Y. , Ahn S.-H. , Yoon K.-S. , Kang C.-S. , Cho H.M. , Lee H.S. , Choe J.J. , Choi C.W. , Kim B.S. , Shin S.W. , Kim Y.H. , Kim J.S. , Son G.-S. , Lee J.-B. , Koo B.H.
Hum. Mutat.24:350-350(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC THR-1445; VAL-1929 AND ALA-2031;VARIANTS HIS-289; ASN-372; VAL-784; ASP-991 AND VAL-3412
66.

"Prevalence of BRCA2 mutations in a hospital based series of unselected breast cancer cases."
Kim S.-W. , Lee C.S. , Fey J.V. , Borgen P.I. , Boyd J.
J. Med. Genet.42:E5-E5(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-1172; TYR-1420; PHE-2944; ASN-2950 AND ILE-3013
67.

"A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes."
Easton D.F. , Deffenbaugh A.M. , Pruss D. , Frye C. , Wenstrup R.J. , Allen-Brady K. , Tavtigian S.V. , Monteiro A.N.A. , Iversen E.S. , Couch F.J. , Goldgar D.E.
Am. J. Hum. Genet.81:873-883(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-2336; CYS-2502; CYS-2626; PHE-2627; PRO-2653; LYS-2659; VAL-2663; ARG-2722; GLY-2723; ASP-2748 AND GLU-3095
68.

"Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2."
Alter B.P. , Rosenberg P.S. , Brody L.C.
J. Med. Genet.44:1-9(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FANCD1 HIS-2336 AND CYS-2626
69.

"Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity."
Walker L.C. , Whiley P.J. , Couch F.J. , Farrugia D.J. , Healey S. , Eccles D.M. , Lin F. , Butler S.A. , Goff S.A. , Thompson B.A. , Lakhani S.R. , Da Silva L.M. , Tavtigian S.V. , Goldgar D.E. , Brown M.A. , Spurdle A.B.
Hum. Mutat.31:E1484-E1505(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS VAL-2663; GLY-2723 AND TRP-3052

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