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Index > Protein center > C1QA(Gene name) > Human
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  • C1QA (Gene name),
  • Complement C1q subcomponent subunit A (Protein name ),  C1QA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    C1QA;
    Protein name:
    Complement C1q subcomponent subunit A;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.
    Function:
    C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    245
    Sequence:
    50:
    MEGPRGWLVL | CVLAISLASM | VTEDLCRAPD | GKKGEAGRPG | RRGRPGLKGE | 
    100:
    QGEPGAPGIR | TGIQGLKGDQ | GEPGPSGNPG | KVGYPGPSGP | LGARGIPGIK | 
    150:
    GTKGSPGNIK | DQPRPAFSAI | RRNPPMGGNV | VIFDTVITNQ | EEPYQNHSGR | 
    200:
    FVCTVPGYYY | FTFQVLSQWE | ICLSIVSSSR | GQVRRSLGFC | DTTNKGLFQV | 
    245:
    VSGGMVLQLQ | QGDQVWVEKD | PKKGHIYQGS | EADSVFSGFL | IFPSA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    E0747h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    E0747m
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    E0747b
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    E0747p
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    E0747r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    U0747b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    U0747r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    U0747p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    U0747m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Complement C1q subcomponent subunit A
    Cat.:
    U0747h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Complement C1q subcomponent subunit A
    Polyclonal Antibody for Human Complement C1q subcomponent subunit A
    Cat.:
    P0747Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement C1q subcomponent subunit A
    Cat.:
    P0747Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement C1q subcomponent subunit A
    Polyclonal Antibody for Human Complement C1q subcomponent subunit A
    Cat.:
    P0747Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Complement C1q subcomponent subunit A
    Monoclonal Antibody for Human Complement C1q subcomponent subunit A
    Monoclonal Antibody for Human Complement C1q subcomponent subunit A
    Monoclonal Antibody for Human Complement C1q subcomponent subunit A
    Monoclonal Antibody for Human Complement C1q subcomponent subunit A
    Protein for Human Complement C1q subcomponent subunit A
    Protein for Human Complement C1q subcomponent subunit A
    Cat.:
    R0747h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Complement C1q subcomponent subunit A
    Protein for Human Complement C1q subcomponent subunit A
    Protein for Human Complement C1q subcomponent subunit A

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q."
      Sellar G.C. , Blake D.J. , Reid K.B.M.
      Biochem. J.274:481-490(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Monocyte.
    2. 2.
      Wan T. , Zhang W. , Cao X.
      Submitted (1999-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LYS-23
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Spleen.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Spleen.
    8. 8.
      "Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement."
      Reid K.B.M.
      Biochem. J.179:367-371(1979) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-130;HYDROXYLATION AT LYS-33; PRO-39; PRO-45; LYS-48; PRO-54; PRO-57; LYS-67; PRO-73; PRO-79; PRO-85 AND LYS-100
    9. 9.
      "Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement."
      Reid K.B.M. , Gagnon J. , Frampton J.
      Biochem. J.203:559-569(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 131-245
    10. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-146
      tissue: Plasma.
    11. 11.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-146
      tissue: Liver.
    12. 12.
      "The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties."
      Gaboriaud C. , Juanhuix J. , Gruez A. , Lacroix M. , Darnault C. , Pignol D. , Verger D. , Fontecilla-Camps J.-C. , Arlaud G.J.
      J. Biol. Chem.278:46974-46982(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 112-244
    13. 13.
      "Molecular basis of hereditary C1q deficiency."
      Petry F.
      Immunobiology199:286-294(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON C1Q DEFICIENCY
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