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Index > Protein center > C1QC(Gene name) > Human
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  • C1QC (Gene name),
  • Complement C1q subcomponent subunit C (Protein name ),  C1QC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    C1QC(C1QG);
    Protein name:
    Complement C1q subcomponent subunit C;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.
    Function:
    C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    245
    Sequence:
    50:
    MDVGPSSLPH | LGLKLLLLLL | LLPLRGQANT | GCYGIPGMPG | LPGAPGKDGY | 
    100:
    DGLPGPKGEP | GIPAIPGIRG | PKGQKGEPGL | PGHPGKNGPM | GPPGMPGVPG | 
    150:
    PMGIPGEPGE | EGRYKQKFQS | VFTVTRQTHQ | PPAPNSLIRF | NAVLTNPQGD | 
    200:
    YDTSTGKFTC | KVPGLYYFVY | HASHTANLCV | LLYRSGVKVV | TFCGHTSKTN | 
    245:
    QVNSGGVLLR | LQVGEEVWLA | VNDYYDMVGI | QGSDSVFSGF | LLFPD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement C1q subcomponent subunit C
    Cat.:
    E0339h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Complement C1q subcomponent subunit C
    Cat.:
    E0339r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Complement C1q subcomponent subunit C
    Cat.:
    E0339m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement C1q subcomponent subunit C
    Cat.:
    U0339m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement C1q subcomponent subunit C
    Cat.:
    U0339h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Complement C1q subcomponent subunit C
    Cat.:
    U0339r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Complement C1q subcomponent subunit C
    Cat.:
    P0339Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement C1q subcomponent subunit C
    Cat.:
    P0339Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement C1q subcomponent subunit C
    Cat.:
    P0339Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Complement C1q subcomponent subunit C
    Monoclonal Antibody for Human Complement C1q subcomponent subunit C
    Monoclonal Antibody for Human Complement C1q subcomponent subunit C
    Protein for Human Complement C1q subcomponent subunit C
    Protein for Human Complement C1q subcomponent subunit C
    Protein for Human Complement C1q subcomponent subunit C

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q."
      Sellar G.C. , Blake D.J. , Reid K.B.M.
      Biochem. J.274:481-490(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Monocyte.
    2. 2.
      "Cloning and characterization of a novel human cDNA homology to murine C1q C-chain mRNA."
      Dai F.Y. , Yu L. , Wan Y.Z. , Zhang H.L. , Huang J. , Zhao S.Y.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cerebellum.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement."
      Reid K.B.M.
      Biochem. J.179:367-371(1979) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-122;HYDROXYLATION AT PRO-36; PRO-39; PRO-42; PRO-45; PRO-54; PRO-63; LYS-75; PRO-81; PRO-93; PRO-96; PRO-99 AND PRO-105
    7. 7.
      "The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties."
      Gaboriaud C. , Juanhuix J. , Gruez A. , Lacroix M. , Darnault C. , Pignol D. , Verger D. , Fontecilla-Camps J.-C. , Arlaud G.J.
      J. Biol. Chem.278:46974-46982(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 117-245
    8. 8.
      "Molecular basis of hereditary C1q deficiency."
      Petry F.
      Immunobiology199:286-294(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON C1Q DEFICIENCY
    9. 9.
      "Homozygous hereditary C1q deficiency and systemic lupus erythematosus. A new family and the molecular basis of C1q deficiency in three families."
      Slingsby J.H. , Norsworthy P. , Pearce G. , Vaishnaw A.K. , Issler H. , Morley B.J. , Walport M.J.
      Arthritis Rheum.39:663-670(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C1QD ARG-34
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