C1R ELISA Kit for Human(Homo sapiens) | EIAab.comC1R ELISA Kit for Human(Homo sapiens)

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Index > Protein center > C1R(Gene name) > Human

C1R (Gene name),

Complement C1r subcomponent (Protein name ), C1R_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

C1R;

Protein name:

Complement C1r subcomponent;

Alternative:

Complement component 1 subcomponent r;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.

Function:

C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

705

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

705:

MEEED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P00736

UniGene:

Hs.524224

String:

P00736

Pfam:

PF00431

KEGG:

hsa:715

STRING:

9606.ENSP00000290575

MIM:

216950

Uniprot:

P00736

FOR

ELISA Kit for Human Complement C1r subcomponent

CLIA Kit for Human Complement C1r subcomponent

Polyclonal Antibody for Human Complement C1r subcomponent

Monoclonal Antibody for Human Complement C1r subcomponent

Protein for Human Complement C1r subcomponent

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Nucleotide sequence of the cDNA coding for human complement C1r."
Leytus S.P. , Kurachi K. , Sakariassen K.S. , Davie E.W.
Biochemistry25:4855-4863(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-186
2.

"Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r."
Journet A. , Tosi M.
Biochem. J.240:783-787(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS LEU-152 AND ARG-186
3.

"The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity."
Nakagawa M. , Yuasa I. , Irizawa Y. , Umetsu K.
Ann. Hum. Genet.67:207-215(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-131; LEU-152; TYR-163; LYS-184; ARG-186 AND ARG-261
4.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon endothelium.
5.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS LEU-152 AND ARG-186
tissue: Skin.
7.

"Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r."
Arlaud G.J. , Willis A.C. , Gagnon J.
Biochem. J.241:711-720(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-463
8.

"Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r."
Arlaud G.J. , Gagnon J.
Biochemistry22:1758-1764(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 464-705
9.

"Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r."
Arlaud G.J. , van Dorsselaer A. , Bell A. , Mancini M. , Aude C. , Gagnon J.
FEBS Lett.222:129-134(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 152-186;HYDROXYLATION AT ASN-167
10.

"Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction."
Pelloux S. , Thielens N.M. , Hudry-Clergeon G. , Petillot Y. , Filhol O. , Arlaud G.J.
FEBS Lett.386:15-20(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 133-137; 187-211 AND 609-613;PHOSPHORYLATION AT SER-206 BY CK2
11.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125; ASN-221 AND ASN-514
tissue: Plasma.
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-514
tissue: Liver.
13.

"Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family."
Bersch B. , Hernandez J.-F. , Marion D. , Arlaud G.J.
Biochemistry37:1204-1214(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 140-192
14.

"The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex."
Budayova-Spano M. , Lacroix M. , Thielens N.M. , Arlaud G.J. , Fontecilla-Camps J.-C. , Gaboriaud C.
EMBO J.21:231-239(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 307-702
15.

"Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism."
Budayova-Spano M. , Grabarse W. , Thielens N.M. , Hillen H. , Lacroix M. , Schmidt M. , Fontecilla-Camps J.-C. , Arlaud G.J. , Gaboriaud C.
Structure10:1509-1519(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 375-702
16.

"A common amino acid polymorphism in complement component C1R."
Nothen M.M. , Dewald G.
Hum. Mol. Genet.3:217-217(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-152
17.

"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
Su Z.D. , Sun L. , Yu D.X. , Li R.X. , Li H.X. , Yu Z.J. , Sheng Q.H. , Lin X. , Zeng R. , Wu J.R.
J. Mol. Cell Biol.3:309-315(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-184 AND ARG-261;IDENTIFICATION BY MASS SPECTROMETRY

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