C1S ELISA Kit for Human(Homo sapiens) | EIAab.comC1S ELISA Kit for Human(Homo sapiens)

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Index > Protein center > C1S(Gene name) > Human

C1S (Gene name),

Complement C1s subcomponent (Protein name ), C1S_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

C1S;

Protein name:

Complement C1s subcomponent;

Alternative:

Complement component 1 subcomponent s;C1 esterase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.

Function:

C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

688

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

688:

GLVSWGPQCG | TYGLYTRVKN | YVDWIMKTMQ | ENSTPRED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

120580

SMR:

P09871

Pfam:

PF00431

KEGG:

hsa:716

String:

P09871

UniGene:

Hs.458355

Uniprot:

P09871

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ELISA Kit for Human Complement C1s subcomponent

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ELISA Kit for Human Complement C1s subcomponent

Cat.:

E15018h

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Manual:

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Packing:

96T

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ELISA Kit for Human Complement C1s subcomponent

MSDS:

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CLIA Kit for Human Complement C1s subcomponent

MSDS:

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CLIA Kit for Human Complement C1s subcomponent

MSDS:

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CLIA Kit for Human Complement C1s subcomponent

Cat.:

U15018h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Complement C1s subcomponent

Monoclonal Antibody for Human Complement C1s subcomponent

Protein for Human Complement C1s subcomponent

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence."
McKinnon C.M. , Carter P.E. , Smyth S.J. , Dunbar B. , Fothergill J.E.
Eur. J. Biochem.169:547-553(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr."
Tosi M. , Duponchel C. , Meo T. , Julier C.
Biochemistry26:8516-8524(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Human genes for complement components C1r and C1s in a close tail-to-tail arrangement."
Kusumoto H. , Hirosawa S. , Salier J.-P. , Hagen F.S. , Kurachi K.
Proc. Natl. Acad. Sci. U.S.A.85:7307-7311(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: PNS.
6.

"Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates."
Endo Y. , Takahashi M. , Nakao M. , Saiga H. , Sekine H. , Matsushita M. , Nonaka M. , Fujita T.
J. Immunol.161:4924-4930(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-329
tissue: Peripheral blood leukocyte.
7.

"Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin."
Tosi M. , Duponchel C. , Meo T. , Couture-Tosi E.
J. Mol. Biol.208:709-714(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 291-688
8.

"Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation."
Spycher S.E. , Nick H. , Rickli E.E.
Eur. J. Biochem.156:49-57(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 16-61; 168-219; 287-334 AND 384-445
9.

"The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments."
Carter P.E. , Dunbar B. , Fothergill J.E.
Biochem. J.215:565-571(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 438-500; 503-534; 542-601; 617-623 AND 626-656
10.

"Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region."
Thielens N.M. , van Dorsselaer A. , Gagnon J. , Arlaud G.J.
Biochemistry29:3570-3578(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT ASN-174;HYDROXYLATION AT ASN-149
11.

"Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites."
Illy C. , Thielens N.M. , Gagnon J. , Arlaud G.J.
Biochemistry30:7135-7141(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
tissue: Plasma.
12.

"Identification of the disulfide bonds of human complement C1s."
Hess D. , Schaller J. , Rickli E.E.
Biochemistry30:2827-2833(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
13.

"Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling."
Rossi V. , Gaboriaud C. , Lacroix M. , Ulrich J. , Fontecilla-Camps J.-C. , Gagnon J. , Arlaud G.J.
Biochemistry34:7311-7321(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;3D-STRUCTURE MODELING OF CATALYTIC DOMAIN
14.

"Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2."
Rossi V. , Cseh S. , Bally I. , Thielens N.M. , Jensenius J.C. , Arlaud G.J.
J. Biol. Chem.276:40880-40887(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
15.

"Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases."
Dragon-Durey M.-A. , Quartier P. , Fremeaux-Bacchi V. , Blouin J. , de Barace C. , Prieur A.-M. , Weiss L. , Fridman W.-H.
J. Immunol.166:7612-7616(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN COMPLEMENT COMPONENT C1S DEFICIENCY
16.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-406
tissue: Plasma.
17.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174 AND ASN-406
tissue: Liver.
18.

"Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle."
Gaboriaud C. , Rossi V. , Bally I. , Arlaud G.J. , Fontecilla-Camps J.-C.
EMBO J.19:1755-1765(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 358-688
19.

"X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement."
Gregory L.A. , Thielens N.M. , Arlaud G.J. , Fontecilla-Camps J.-C. , Gaboriaud C.
J. Biol. Chem.278:32157-32164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 16-174;CALCIUM-BINDING SITES;GLYCOSYLATION AT ASN-406

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