Casp8ap2 ELISA Kit for Mouse(Mus musculus) | EIAab.comCasp8ap2 ELISA Kit for Mouse(Mus musculus)

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Casp8ap2 (Gene name),

CASP8-associated protein 2 (Protein name ), C8AP2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Casp8ap2(Flash);

Protein name:

CASP8-associated protein 2;

Alternative:

FLICE-associated huge protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with NPAT and SRRT/ARS2 (By similarity). Self-associates. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with NCOA2, NCOA3 and TRAF2.

Function:

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis.

Subcellular Location:

Cytoplasm Nucleus Localizes to discrete nuclear foci.

Protein Attributes:

Sequence length:

1962

Sequence:

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1962:

QLKKLFEKSK | CR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000029950

SMR:

Q9WUF3

String:

Q9WUF3

UniGene:

Mm.22279

KEGG:

mmu:26885

Uniprot:

Q9WUF3

FOR

ELISA Kit for Mouse CASP8-associated protein 2

CLIA Kit for Mouse CASP8-associated protein 2

Polyclonal Antibody for Mouse CASP8-associated protein 2

Monoclonal Antibody for Mouse CASP8-associated protein 2

Protein for Mouse CASP8-associated protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis."
Imai Y. , Kimura T. , Murakami A. , Yajima N. , Sakamaki K. , Yonehara S.
Nature398:777-785(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN DISC COMPLEX WITH CASP8; FADD AND FAS;TISSUE SPECIFICITY
tissue: T-cell lymphoma.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1766-1962
strain: C57BL/6J.
tissue: Embryo.
5.

"FLASH coordinates NF-kappa B activity via TRAF2."
Choi Y.-H. , Kim K.-B. , Kim H.-H. , Hong G.-S. , Kwon Y.-K. , Chung C.-W. , Park Y.-M. , Shen Z.-J. , Kim B.J. , Lee S.-Y. , Jung Y.-K.
J. Biol. Chem.276:25073-25077(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRAF2
6.

"Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway."
Jun J.-I. , Chung C.-W. , Lee H.-J. , Pyo J.-O. , Lee K.N. , Kim N.-S. , Kim Y.S. , Yoo H.-S. , Lee T.-H. , Kim E. , Jung Y.-K.
Oncogene24:688-696(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"FLASH is required for histone transcription and S-phase progression."
Barcaroli D. , Bongiorno-Borbone L. , Terrinoni A. , Hofmann T.G. , Rossi M. , Knight R.A. , Matera A.G. , Melino G. , De Laurenzi V.
Proc. Natl. Acad. Sci. U.S.A.103:14808-14812(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
8.

"FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies."
Milovic-Holm K. , Krieghoff E. , Jensen K. , Will H. , Hofmann T.G.
EMBO J.26:391-401(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASP8
9.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1323;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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