Gene name:
CACNA2D1 (CACNL2A;CCHL2A) ;
Protein name:
Voltage-dependent calcium channel subunit alpha-2/delta-1 ;
Alternative:
Voltage-gated calcium channel subunit alpha-2/delta-1 ;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio.
Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MAAGRPLAWT | LTLWQAWLIL | IGPSSEEPFP | SAVTIKSWVD | KMQEDLVTLA |
100:
KTASGVHQLV | DIYEKYQDLY | TVEPNNARQL | VEIAARDIEK | LLSNRSKALV |
150:
RLALEAEKVQ | AAHQWREDFA | SNEVVYYNAK | DDLDPEKNDS | EPGSQRIKPV |
200:
FIDDANFRRQ | VSYQHAAVHI | PTDIYEGSTI | VLNELNWTSA | LDDVFKKNRE |
250:
EDPSLLWQVF | GSATGLARYY | PASPWVDNSR | TPNKIDLYDV | RRRPWYIQGA |
300:
ASPKDMLILV | DVSGSVSGLT | LKLIRTSVSE | MLETLSDDDF | VNVASFNSNA |
350:
QDVSCFQHLV | QANVRNKKVL | KDAVNNITAK | GITDYKKGFS | FAFEQLLNYN |
400:
VSRANCNKII | MLFTDGGEER | AQEIFAKYNK | DKKVRVFTFS | VGQHNYDRGP |
450:
IQWMACENKG | YYYEIPSIGA | IRINTQEYLD | VLGRPMVLAG | DKAKQVQWTN |
500:
VYLDALELGL | VITGTLPVFN | ITGQFENKTN | LKNQLILGVM | GVDVSLEDIK |
550:
RLTPRFTLCP | NGYYFAIDPN | GYVLLHPNLQ | PKPIGVGIPT | INLRKRRPNV |
600:
QNPKSQEPVT | LDFLDAELEN | DIKVEIRNKM | IDGESGEKTF | RTLVKSQDER |
650:
YIDKGNRTYT | WTPVNGTDYS | SLALVLPTYS | FYYIKAKIEE | TITQARYSET |
700:
LKPDNFEESG | YTFLAPRDYC | SDLKPSDNNT | EFLLNFNEFI | DRKTPNNPSC |
750:
NTDLINRVLL | DAGFTNELVQ | NYWSKQKNIK | GVKARFVVTD | GGITRVYPKE |
800:
AGENWQENPE | TYEDSFYKRS | LDNDNYVFTA | PYFNKSGPGA | YESGIMVSKA |
850:
VEIYIQGKLL | KPAVVGIKID | VNSWIENFTK | TSIRDPCAGP | VCDCKRNSDV |
900:
MDCVILDDGG | FLLMANHDDY | TNQIGRFFGE | IDPSLMRHLV | NISVYAFNKS |
950:
YDYQSVCEPG | AAPKQGAGHR | SAYVPSIADI | LQIGWWATAA | AWSILQQFLL |
1000:
SLTFPRLLEA | ADMEDDDFTA | SMSKQSCITE | QTQYFFDNDS | KSFSGVLDCG |
1050:
NCSRIFHVEK | LMNTNLIFIM | VESKGTCPCD | TRLLIQAEQT | SDGPDPCDMV |
1100:
KQPRYRKGPD | VCFDNNVLED | YTDCGGVSGL | NPSLWSIIGI | QFVLLWLVSG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rabbit
Human
Rat
ELISA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
ELISA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
ELISA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
ELISA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
CLIA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
CLIA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
CLIA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
CLIA Kit for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Polyclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Polyclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Polyclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Polyclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Monoclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Monoclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Monoclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Monoclonal Antibody for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Protein for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Protein for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Protein for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
Protein for Rabbit Voltage-dependent calcium channel subunit alpha-2/delta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel."
Ellis S.B.
,
Williams M.E.
,
Ways N.R.
,
Brenner R.
,
Sharp A.H.
,
Leung A.T.
,
Campbell K.P.
,
McKenna E.
,
Koch W.J.
,
Hui A.
,
Schwartz A.
,
Harpold M.M.
Science241:1661-1664(1988)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 27-47
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 961-973
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 961-975; 992-1000 AND 1033-1050;PROTEOLYTIC PROCESSING;SUBUNIT