Cables1 ELISA Kit for Mouse(Mus musculus) | EIAab.comCables1 ELISA Kit for Mouse(Mus musculus)

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Cables1 (Gene name),

CDK5 and ABL1 enzyme substrate 1 (Protein name ), CABL1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cables1(Cables);

Protein name:

CDK5 and ABL1 enzyme substrate 1;

Alternative:

Interactor with CDK3 1(Ik3-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Found in a complex with p53/TP53 (By similarity). Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7.

Function:

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death.

Subcellular Location:

Nucleus Cytoplasm Cell projection growth cone Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.

Protein Attributes:

Sequence length:

568

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

568:

HLPEHEVMPH | YRRLIQSS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9ESJ1

KEGG:

mmu:63955

SMR:

Q9ESJ1

UniGene:

Mm.40717

Pfam:

PF00134

Uniprot:

Q9ESJ1

FOR

ELISA Kit for Mouse CDK5 and ABL1 enzyme substrate 1

CLIA Kit for Mouse CDK5 and ABL1 enzyme substrate 1

Polyclonal Antibody for Mouse CDK5 and ABL1 enzyme substrate 1

Monoclonal Antibody for Mouse CDK5 and ABL1 enzyme substrate 1

Protein for Mouse CDK5 and ABL1 enzyme substrate 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth."
Zukerberg L.R. , Patrick G.N. , Nikolic M. , Humbert S. , Wu C.-L. , Lanier L.M. , Gertler F.B. , Vidal M. , Van Etten R.A. , Tsai L.-H.
Neuron26:633-646(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;PHOSPHORYLATION BY CDK5 AND ABL1;IDENTIFICATION IN A TRIMOLECULAR COMPLEX WITH CDK5 AND ABL1;INTERACTION WITH CDK5 AND ABL1
tissue: Brain.
2.

"Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo."
Matsuoka M. , Matsuura Y. , Semba K. , Nishimoto I.
Biochem. Biophys. Res. Commun.273:442-447(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROBABLE FUNCTION IN G1-S CELL CYCLE TRANSITION;TISSUE SPECIFICITY;INTERACTION WITH CDK3
strain: BALB/c.
tissue: Brain.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)."
Yamochi T. , Semba K. , Tsuji K. , Mizumoto K. , Sato H. , Matsuura Y. , Nishimoto I. , Matsuoka M.
Eur. J. Biochem.268:6076-6082(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CCNA1/CDK2; CCNE1/CDK2; CCNA1/CDK3 AND CCNE1/CDK3;PHOSPHORYLATION AT SER-274;MUTAGENESIS OF SER-274
5.

"ik3-1/Cables is associated with Trap and Pctaire2."
Yamochi T. , Nishimoto I. , Okuda T. , Matsuoka M.
Biochem. Biophys. Res. Commun.286:1045-1050(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH TDRD7;IDENTIFICATION IN A COMPLEX WITH TDRD7 AND CDK17
6.

"Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
Wu C.-L. , Kirley S.D. , Xiao H. , Chuang Y. , Chung D.C. , Zukerberg L.R.
Cancer Res.61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION IN A COMPLEX WITH CDK2; CCNA1 AND CCNE1;INTERACTION WITH CDK2
7.

"Differential effect of ik3-1/cables on p53- and p73-induced cell death."
Tsuji K. , Mizumoto K. , Yamochi T. , Nishimoto I. , Matsuoka M.
J. Biol. Chem.277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL DEATH;SUBCELLULAR LOCATION;IDENTIFICATION IN A COMPLEX WITH TP53 AND TP73

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