Cacna1b ELISA Kit for Mouse(Mus musculus) | EIAab.comCacna1b ELISA Kit for Mouse(Mus musculus)

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Cacna1b (Gene name),

Voltage-dependent N-type calcium channel subunit alpha-1B (Protein name ), CAC1B_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1b(Cach5;Cacnl1a5;Cchn1a);

Protein name:

Voltage-dependent N-type calcium channel subunit alpha-1B;

Alternative:

Calcium channel, L type, alpha-1 polypeptide isoform 5;Brain calcium channel III(BIII);Voltage-gated calcium channel subunit alpha Cav2.2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2327

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2327:

GYHCTLGLST | GVRARHSYHH | PDQDHWC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

String:

O55017

SMR:

O55017

UniGene:

Mm.4424

KEGG:

mmu:12287

Uniprot:

O55017

FOR

ELISA Kit for Mouse Voltage-dependent N-type calcium channel subunit alpha-1B

CLIA Kit for Mouse Voltage-dependent N-type calcium channel subunit alpha-1B

Polyclonal Antibody for Mouse Voltage-dependent N-type calcium channel subunit alpha-1B

Monoclonal Antibody for Mouse Voltage-dependent N-type calcium channel subunit alpha-1B

Protein for Mouse Voltage-dependent N-type calcium channel subunit alpha-1B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Nucleotide sequence polymorphism of mouse alpha1 B."
Hong T. , Birnbaumer L.
Submitted (1998-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Brain.
2.

"Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization."
Coppola T. , Waldmann R. , Borsotto M. , Heurteaux C. , Romey G. , Mattei M.-G. , Lazdunski M.
FEBS Lett.338:1-5(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS NB1 AND NB2)
tissue: Neuroblastoma.
3.

"Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin."
Coppola T. , Magnin-Luethi S. , Perret-Menoud V. , Gattesco S. , Schiavo G. , Regazzi R.
J. Biol. Chem.276:32756-32762(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIMS1
tissue: Brain.
4.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
5.

"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain cortex.

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