Cacna1b ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCacna1b ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Cacna1b(Gene name) > Rat

Cacna1b (Gene name),

Voltage-dependent N-type calcium channel subunit alpha-1B (Protein name ), CAC1B_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1b(Cach5;Cacnl1a5);

Protein name:

Voltage-dependent N-type calcium channel subunit alpha-1B;

Alternative:

Calcium channel, L type, alpha-1 polypeptide isoform 5;Brain calcium channel III(BIII);Voltage-gated calcium channel subunit alpha Cav2.2;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2336

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2336:

SHPLRRVPNG | YHCTLGLSTG | VRARHSYHHP | DQDHWC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

UniGene:

Rn.85880

String:

Q02294

Uniprot:

Q02294

FOR

ELISA Kit for Rat Voltage-dependent N-type calcium channel subunit alpha-1B

CLIA Kit for Rat Voltage-dependent N-type calcium channel subunit alpha-1B

Polyclonal Antibody for Rat Voltage-dependent N-type calcium channel subunit alpha-1B

Monoclonal Antibody for Rat Voltage-dependent N-type calcium channel subunit alpha-1B

Protein for Rat Voltage-dependent N-type calcium channel subunit alpha-1B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel."
Dubel S.J. , Starr T.V.B. , Hell J.W. , Ahlijanian M.K. , Enyeart J.J. , Catterall W.A. , Snutch T.P.
Proc. Natl. Acad. Sci. U.S.A.89:5058-5062(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Brain.
2.

"Rat brain expresses a heterogeneous family of calcium channels."
Snutch T.P. , Leonard J.P. , Gilbert M.M. , Lester H.A. , Davidson N.
Proc. Natl. Acad. Sci. U.S.A.87:3391-3395(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1516-1679 (CLONE RBB-10)
3.

"Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini."
Hell J.W. , Appleyard S.M. , Yokoyama C.T. , Warner C. , Catterall W.A.
J. Biol. Chem.269:7390-7396(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
4.

"Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit."
Pragnell M. , de Waard M. , Mori Y. , Tanabe T. , Snutch T.P. , Campbell K.P.
Nature368:67-70(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BETA-SUBUNIT BINDING DOMAIN

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