CACNA1H ELISA Kit for Human(Homo sapiens) | EIAab.comCACNA1H ELISA Kit for Human(Homo sapiens)

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CACNA1H (Gene name),

Voltage-dependent T-type calcium channel subunit alpha-1H (Protein name ), CAC1H_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CACNA1H;

Protein name:

Voltage-dependent T-type calcium channel subunit alpha-1H;

Alternative:

Voltage-gated calcium channel subunit alpha Cav3.2;Low-voltage-activated calcium channel alpha1 3.2 subunit;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2353

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DPV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O95180

KEGG:

hsa:8912

MIM:

607904

Pfam:

PF00520

SMR:

O95180

UniGene:

Hs.459642

STRING:

9606.ENSP00000334198

Uniprot:

O95180

FOR

ELISA Kit for Human Voltage-dependent T-type calcium channel subunit alpha-1H

CLIA Kit for Human Voltage-dependent T-type calcium channel subunit alpha-1H

Polyclonal Antibody for Human Voltage-dependent T-type calcium channel subunit alpha-1H

Monoclonal Antibody for Human Voltage-dependent T-type calcium channel subunit alpha-1H

Protein for Human Voltage-dependent T-type calcium channel subunit alpha-1H

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family."
Cribbs L.L. , Lee J.-H. , Yang J. , Satin J. , Zhang Y. , Daud A.N. , Barclay J. , Wiliamson M.P. , Fox M. , Rees M. , Perez-Reyes E.
Circ. Res.83:103-109(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-664
tissue: Heart.
2.

Cribbs L.L. , Lee J.-H. , Yang J. , Daud A.N. , Perez-Reyes E.
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"Structure and functional characterization of a novel human low-voltage activated calcium channel."
Williams M.E. , Washburn M.S. , Hans M. , Urrutia A. , Brust P.F. , Prodanovich P. , Harpold M.M. , Stauderman K.A.
J. Neurochem.72:791-799(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT HIS-2077
tissue: Thyroid carcinoma.
4.

"Identification and localization of T-type voltage-operated calcium channel subunits in human male germ cells. Expression of multiple isoforms."
Jagannathan S. , Punt E.L. , Gu Y. , Arnoult C. , Sakkas D. , Barratt C.L. , Publicover S.J.
J. Biol. Chem.277:8449-8456(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ALA-664
tissue: Testis.
5.

"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J. , Peden J.F. , Lloyd C. , Horsley S.W. , Clark K. , Tufarelli C. , Kearney L. , Buckle V.J. , Doggett N.A. , Flint J. , Higgs D.R.
Hum. Mol. Genet.10:339-352(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS VAL-313 AND HIS-2060
6.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT VAL-313
7.

"Organization and alternative splicing of CACNA1H."
Mittman S. , Agnew W.S.
Submitted (2001-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 424-661 AND 838-2373 (ISOFORM 1);VARIANTS LEU-640 AND HIS-2077
8.

"Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channels."
Kang H.W. , Vitko I. , Lee S.S. , Perez-Reyes E. , Lee J.H.
J. Biol. Chem.285:3271-3281(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ZINC-BINDING SITES
9.

"Association between genetic variation of CACNA1H and childhood absence epilepsy."
Chen Y. , Lu J. , Pan H. , Zhang Y. , Wu H. , Xu K. , Liu X. , Jiang Y. , Bao X. , Yao Z. , Ding K. , Lo W.H. , Qiang B. , Chan P. , Shen Y. , Wu X.
Ann. Neurol.54:239-243(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ECA6 LEU-161; LYS-282; SER-456; SER-499; LEU-648; GLN-744; VAL-748; ASP-773; SER-784; MET-831; SER-848 AND ASN-1463;VARIANTS VAL-313; LEU-640; ALA-664; SER-684; CYS-788; HIS-2060; HIS-2077 AND SER-2173
10.

"Genetic variation of CACNA1H in idiopathic generalized epilepsy."
Heron S.E. , Phillips H.A. , Mulley J.C. , Mazarib A. , Neufeld M.Y. , Berkovic S.F. , Scheffer I.E.
Ann. Neurol.55:595-596(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IGE6 LEU-618 AND ASP-755

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