Cacna1i ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCacna1i ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Cacna1i(Gene name) > Rat

Cacna1i (Gene name),

Voltage-dependent T-type calcium channel subunit alpha-1I (Protein name ), CAC1I_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1i;

Protein name:

Voltage-dependent T-type calcium channel subunit alpha-1I;

Alternative:

Voltage-gated calcium channel subunit alpha Cav3.3;CaVT.3;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2201

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3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00520

UniGene:

Rn.48680

KEGG:

rno:56827

Uniprot:

Q9Z0Y8

FOR

ELISA Kit for Rat Voltage-dependent T-type calcium channel subunit alpha-1I

CLIA Kit for Rat Voltage-dependent T-type calcium channel subunit alpha-1I

Polyclonal Antibody for Rat Voltage-dependent T-type calcium channel subunit alpha-1I

Monoclonal Antibody for Rat Voltage-dependent T-type calcium channel subunit alpha-1I

Protein for Rat Voltage-dependent T-type calcium channel subunit alpha-1I

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family."
Lee J.-H. , Daud A.N. , Cribbs L.L. , Lacerda A.E. , Pereverzev A. , Kloeckner U. , Schneider T. , Perez-Reyes E.
J. Neurosci.19:1912-1921(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: Sprague-Dawley.
tissue: Brain.
2.

Perez-Reyes E.
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 345; 1656 AND 1737
3.

"Molecular and functional characterization of a family of rat brain T-type calcium channels."
McRory J.E. , Santi C.M. , Hamming K.S.C. , Mezeyova J. , Sutton K.G. , Baillie D.L. , Stea A. , Snutch T.P.
J. Biol. Chem.276:3999-4011(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
4.

McRory J.E.
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION

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