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Index > Protein center > CDH3(Gene name) > Human
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  • CDH3 (Gene name),
  • Cadherin-3 (Protein name ),  CADH3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CDH3(CDHP);
    Protein name:
    Cadherin-3;
    Alternative:
    Placental cadherin(P-cadherin);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CDCP1.
    Function:
    Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    829
    Sequence:
    50:
    MGLPRGPLAS | LLLLQVCWLQ | CAASEPCRAV | FREAEVTLEA | GGAEQEPGQA | 
    100:
    LGKVFMGCPG | QEPALFSTDN | DDFTVRNGET | VQERRSLKER | NPLKIFPSKR | 
    150:
    ILRRHKRDWV | VAPISVPENG | KGPFPQRLNQ | LKSNKDRDTK | IFYSITGPGA | 
    200:
    DSPPEGVFAV | EKETGWLLLN | KPLDREEIAK | YELFGHAVSE | NGASVEDPMN | 
    250:
    ISIIVTDQND | HKPKFTQDTF | RGSVLEGVLP | GTSVMQVTAT | DEDDAIYTYN | 
    300:
    GVVAYSIHSQ | EPKDPHDLMF | TIHRSTGTIS | VISSGLDREK | VPEYTLTIQA | 
    350:
    TDMDGDGSTT | TAVAVVEILD | ANDNAPMFDP | QKYEAHVPEN | AVGHEVQRLT | 
    400:
    VTDLDAPNSP | AWRATYLIMG | GDDGDHFTIT | THPESNQGIL | TTRKGLDFEA | 
    450:
    KNQHTLYVEV | TNEAPFVLKL | PTSTATIVVH | VEDVNEAPVF | VPPSKVVEVQ | 
    500:
    EGIPTGEPVC | VYTAEDPDKE | NQKISYRILR | DPAGWLAMDP | DSGQVTAVGT | 
    550:
    LDREDEQFVR | NNIYEVMVLA | MDNGSPPTTG | TGTLLLTLID | VNDHGPVPEP | 
    600:
    RQITICNQSP | VRQVLNITDK | DLSPHTSPFQ | AQLTDDSDIY | WTAEVNEEGD | 
    650:
    TVVLSLKKFL | KQDTYDVHLS | LSDHGNKEQL | TVIRATVCDC | HGHVETCPGP | 
    700:
    WKGGFILPVL | GAVLALLFLL | LVLLLLVRKK | RKIKEPLLLP | EDDTRDNVFY | 
    750:
    YGEEGGGEED | QDYDITQLHR | GLEARPEVVL | RNDVAPTIIP | TPMYRPRPAN | 
    800:
    PDEIGNFIIE | NLKAANTDPT | APPYDTLLVF | DYEGSGSDAA | SLSSLTSSAS | 
    829:
    DQDQDYDYLN | EWGSRFKKLA | DMYGGGEDD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cadherin-3
    Cat.:
    E1013h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Cadherin-3
    Cat.:
    E1013m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Human Cadherin-3
    MSDS:
    Please sign in first.
    ELISA Kit for Human Cadherin-3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cadherin-3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cadherin-3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cadherin-3
    Cat.:
    U1013h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cadherin-3
    Cat.:
    U1013m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cadherin-3
    Cat.:
    P1013Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cadherin-3
    Cat.:
    P1013Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cadherin-3
    Polyclonal Antibody for Human Cadherin-3
    Monoclonal Antibody for Human Cadherin-3
    Monoclonal Antibody for Human Cadherin-3
    Monoclonal Antibody for Human Cadherin-3
    Monoclonal Antibody for Human Cadherin-3
    Protein for Human Cadherin-3
    Protein for Human Cadherin-3
    Protein for Human Cadherin-3
    Protein for Human Cadherin-3

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues."
      Shimoyama Y. , Yoshida T. , Terada M. , Shimosato Y. , Abe O. , Hirohashi S.
      J. Cell Biol.109:1787-1794(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT HIS-563
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT HIS-563
      tissue: Tongue.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT HIS-563
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT MET-237
      tissue: Skin.
      tissue: Testis.
    5. 5.
      "P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer."
      Jarrard D.F. , Paul R. , Van Bokhoven A. , Nguyen S.H. , Bova G.S. , Wheelock M.J. , Johnson K.R. , Schalken J. , Bussemakers M. , Isaacs W.B.
      Clin. Cancer Res.3:2121-2128(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15
      tissue: Fetal brain.
    6. 6.
      "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas."
      Shimoyama Y. , Hirohashi S. , Hirano S. , Noguchi M. , Shimosato Y. , Takeichi M. , Abe O.
      Cancer Res.49:2128-2133(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      "Adhesion signaling by a novel mitotic substrate of src kinases."
      Bhatt A.S. , Erdjument-Bromage H. , Tempst P. , Craik C.S. , Moasser M.M.
      Oncogene24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDCP1
    8. 8.
      "Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin."
      Sprecher E. , Bergman R. , Richard G. , Lurie R. , Shalev S. , Petronius D. , Shalata A. , Anbinder Y. , Leibu R. , Perlman I. , Cohen N. , Szargel R.
      Nat. Genet.29:134-136(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HJMD
    9. 9.
      "Crystal structure of a beta-catenin/BCL9/Tcf4 complex."
      Sampietro J. , Dahlberg C.L. , Cho U.S. , Hinds T.R. , Kimelman D. , Xu W.
      Mol. Cell24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy."
      Indelman M. , Bergman R. , Lurie R. , Richard G. , Miller B. , Petronius D. , Ciubutaro D. , Leibu R. , Sprecher E.
      J. Invest. Dermatol.119:1210-1213(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HJMD HIS-503
    12. 12.
      "Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome)."
      Kjaer K.W. , Hansen L. , Schwabe G.C. , Marques-de-Faria A.P. , Eiberg H. , Mundlos S. , Tommerup N. , Rosenberg T.
      J. Med. Genet.42:292-298(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EEM ILE-322;VARIANT HIS-563
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