CDH5 ELISA Kit for Human(Homo sapiens) | EIAab.comCDH5 ELISA Kit for Human(Homo sapiens)

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CDH5 (Gene name),

Cadherin-5 (Protein name ), CADH5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CDH5;

Protein name:

Cadherin-5;

Alternative:

Vascular endothelial cadherin(VE-cadherin);7B4 antigen;

CD:

CD144;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts via cadherin 5 domain with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1.

Function:

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Subcellular Location:

Cell junction Cell membrane Single-pass type I membrane protein Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

Protein Attributes:

Sequence length:

784

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

784:

SDSDVDYDFL | NDWGPRFKML | AELYGSDPRE | ELLY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

601120

STRING:

9606.ENSP00000344115

UniGene:

Hs.76206

String:

P33151

Pfam:

PF00028

SMR:

P33151

KEGG:

hsa:1003

Uniprot:

P33151

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ELISA Kit for Human Cadherin-5

Cat.:

E1366h

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Cadherin-5

Cat.:

E1366b

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MSDS:

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Packing:

96T

ELISA Kit for Human Cadherin-5

Cat.:

E1366m

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MSDS:

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Packing:

96T

ELISA Kit for Human Cadherin-5

Cat.:

E1366c

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MSDS:

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Packing:

96T

ELISA Kit for Human Cadherin-5

Cat.:

E1366p

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MSDS:

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Packing:

96T

CLIA Kit for Human Cadherin-5

Cat.:

U1366c

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Cadherin-5

Cat.:

U1366h

Price:

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Cadherin-5

Cat.:

U1366b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Cadherin-5

Cat.:

U1366p

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Cadherin-5

Cat.:

U1366m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Cadherin-5

Cat.:

P1366Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Cadherin-5

Cat.:

P1366Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cadherin-5

Protein for Human Cadherin-5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin."
Breviario F. , Caveda L. , Corada M. , Martin-Padura I. , Navarro P. , Golay J. , Introna M. , Gulino D. , Lampugnani M.G. , Dejana E.
Arterioscler. Thromb. Vasc. Biol.15:1229-1239(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT THR-517
tissue: Endothelial cell.
2.

"Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion."
Ali J. , Liao F. , Martens E. , Muller W.A.
Microcirculation4:267-277(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Placenta.
3.

"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
Shimoyama Y. , Tsujimoto G. , Kitajima M. , Natori M.
Biochem. J.349:159-167(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT THR-517
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT THR-517
5.

"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
Suzuki S. , Sano K. , Tanihara H.
Cell Regul.2:261-270(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-784 (ISOFORM 1)
tissue: Brain.
6.

"A novel endothelial-specific membrane protein is a marker of cell-cell contacts."
Lampugnani M.G. , Resnati M. , Raiteri M. , Pigott R. , Pisacane A. , Houen G. , Ruco L.P. , Dejana E.
J. Cell Biol.118:1511-1522(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
tissue: Endothelial cell.
7.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112; ASN-442; ASN-523 AND ASN-535
tissue: Plasma.
8.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-61; ASN-112 AND ASN-442
9.

"Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction."
Graziani A. , Poteser M. , Heupel W.M. , Schleifer H. , Krenn M. , Drenckhahn D. , Romanin C. , Baumgartner W. , Groschner K.
J. Biol. Chem.285:4213-4223(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRPC4
10.

"CCM1 regulates vascular-lumen organization by inducing endothelial polarity."
Lampugnani M.G. , Orsenigo F. , Rudini N. , Maddaluno L. , Boulday G. , Chapon F. , Dejana E.
J. Cell Sci.123:1073-1080(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH KRIT1
11.

"Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin."
Brasch J. , Harrison O.J. , Ahlsen G. , Carnally S.M. , Henderson R.M. , Honig B. , Shapiro L.
J. Mol. Biol.408:57-73(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;GLYCOSYLATION AT ASN-61; ASN-112; ASN-157; ASN-362 AND ASN-442

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