Protein name:
Cadherin-5 ;
Alternative:
Vascular endothelial cadherin (VE-cadherin) ;
CD:
CD144 ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Interacts via cadherin 5 domain with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1.
Function:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Subcellular Location:
Cell junction
Cell membrane
Single-pass type I membrane protein
Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Protein Attributes:
50:
MQVLVMLLAA | AGTYLGLLTA | PTAASNPGRQ | DTPSTLPLHR | RQKRDWIWNQ |
100:
MHIDEEKNGS | LPHYVGKIKS | SVNHKNTKYQ | LKGESAGKVF | RVDENTGDVY |
150:
AFERLDREKI | PEYQLVALVV | DKNTEKNLES | PSSFTIKVHD | INDNWPVFTQ |
200:
LVFNASVPEM | SVIGTSVIQL | TAVDADDPTV | ADHASVIYRL | KEGEEHFRIR |
250:
GPGLIETASK | NLDRETVPMY | KIVVETQDAQ | GLRGDSGTAT | VFITLQDVND |
300:
NFPVFTQTRY | TFSVPEDIRV | GSPLGSLFVK | DPDEPQNRKT | KYSIVQGEYR |
350:
DTFTIEPDPT | RNEGIIKPMK | PLDYERIQQY | SFTIEATDPT | IDLRYLSGTS |
400:
TKNIARVIIN | VTDVDEPPNF | KQPFYHFQLR | ENEKKPWIGS | VLAVDPDAAQ |
450:
RSIGYSIRRT | SDKGQFFGIN | KHGNIYNVKE | LDREVYPWYN | LTVEAKELDS |
500:
RGTPTGKESI | VQVHIEVLDE | NDNAPEFAKP | YEAKVCEDAP | QGKLVVQISA |
550:
IDKDVTPRDV | KFKFSLSTED | SNFTLTDNHD | NTANITVKHG | YFDRERAKVH |
600:
HLPILISDNG | RPSLTGTSTL | HVTVCKCNER | GEFTLCEEMG | AQVGVSIQAL |
650:
VAIFLCILTI | AVISLLVYLR | RRLRKQARAH | GKSVPEIHEQ | LVTYDEEGGG |
700:
EMDTTSYDVS | VLNSVRHGGA | KPPRPALDAR | PSLYAQVQKP | PRHAPGAHAP |
750:
GEMAAMIEVK | KDEADHDGGG | PPYDTLHIFG | YEGAESIAES | LSSLGTDSSD |
782:
SDIDYDFLND | WGPRFKMLAE | LYGSDPREEL | LY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Chicken
Pig
ELISA Kit for Pig Cadherin-5
ELISA Kit for Pig Cadherin-5
ELISA Kit for Pig Cadherin-5
ELISA Kit for Pig Cadherin-5
ELISA Kit for Pig Cadherin-5
CLIA Kit for Pig Cadherin-5
CLIA Kit for Pig Cadherin-5
CLIA Kit for Pig Cadherin-5
CLIA Kit for Pig Cadherin-5
CLIA Kit for Pig Cadherin-5
Polyclonal Antibody for Pig Cadherin-5
Polyclonal Antibody for Pig Cadherin-5
Polyclonal Antibody for Pig Cadherin-5
Polyclonal Antibody for Pig Cadherin-5
Polyclonal Antibody for Pig Cadherin-5
Monoclonal Antibody for Pig Cadherin-5
Monoclonal Antibody for Pig Cadherin-5
Monoclonal Antibody for Pig Cadherin-5
Monoclonal Antibody for Pig Cadherin-5
Monoclonal Antibody for Pig Cadherin-5
Protein for Pig Cadherin-5
Protein for Pig Cadherin-5
Protein for Pig Cadherin-5
Protein for Pig Cadherin-5
Protein for Pig Cadherin-5
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
Kilshaw P.J.
Submitted (1997-06) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]