Cadm1 ELISA Kit for Mouse(Mus musculus) | EIAab.comCadm1 ELISA Kit for Mouse(Mus musculus)

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Cadm1 (Gene name),

Cell adhesion molecule 1 (Protein name ), CADM1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cadm1(Igsf4;Necl2;Ra175;Syncam;SynCam1;Tslc1);

Protein name:

Cell adhesion molecule 1;

Alternative:

Nectin-like protein 2(NECL-2);Immunoglobulin superfamily member 4(IgSF4);Synaptic cell adhesion molecule(SynCAM);Spermatogenic immunoglobulin superfamily(SgIgSF);Tumor suppressor in lung cancer 1(TSLC-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with CRTAM and EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6.

Function:

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.

Protein Attributes:

Sequence length:

456

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

456:

KKEYFI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8R5M8

KEGG:

mmu:54725

Pfam:

PF08205

STRING:

10090.ENSMUSP00000083073

SMR:

Q8R5M8

UniGene:

Mm.234832

Uniprot:

Q8R5M8

FOR

ELISA Kit for Mouse Cell adhesion molecule 1

CLIA Kit for Mouse Cell adhesion molecule 1

Polyclonal Antibody for Mouse Cell adhesion molecule 1

Monoclonal Antibody for Mouse Cell adhesion molecule 1

Protein for Mouse Cell adhesion molecule 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene."
Fukami T. , Satoh H. , Fujita E. , Maruyama T. , Fukuhara H. , Kuramochi M. , Takamoto S. , Momoi T. , Murakami Y.
Gene295:7-12(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
strain: 129/SvJ.
2.

"SynCAM, a synaptic adhesion molecule that drives synapse assembly."
Biederer T. , Sara Y. , Mozhayeva M. , Atasoy D. , Liu X. , Kavalali E.T. , Sudhof T.C.
Science297:1525-1531(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;TISSUE SPECIFICITY
strain: C57BL/6.
3.

"RA175, which is the mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer, is a cell adhesion molecule."
Fujita E. , Soyama A. , Momoi T.
Exp. Cell Res.287:57-66(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6 AND 7);FUNCTION
tissue: Embryonic carcinoma.
4.

"Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells."
Shingai T. , Ikeda W. , Kakunaga S. , Morimoto K. , Takekuni K. , Itoh S. , Satoh K. , Takeuchi M. , Imai T. , Monden M. , Takai Y.
J. Biol. Chem.278:35421-35427(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);FUNCTION;INTERACTION WITH MPP6;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: C57BL/6.
tissue: Brain.
5.

"Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane."
Zhou Y. , Du G. , Hu X. , Yu S. , Liu Y. , Xu Y. , Huang X. , Liu J. , Yin B. , Fan M. , Peng X. , Qiang B. , Yuan J.
Biochim. Biophys. Acta1669:142-154(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-456 (ISOFORM 2)
6.

"A secretion form of SgIGSF/TSLC1."
Ito A. , Koma Y. , Nagano T.
Submitted (2002-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
strain: C57BL/6.
tissue: Mast cell.
7.

"Neuron-specific isoforms of RA175/TSLC1/SynCAM."
Fujita E. , Aikawa K. , Momoi T.
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5)
8.

"Expression and functional characterization of the adhesion molecule spermatogenic immunoglobulin superfamily in the mouse testis."
Wakayama T. , Koami H. , Ariga H. , Kobayashi D. , Sai Y. , Tsuji A. , Yamamoto M. , Iseki S.
Biol. Reprod.68:1755-1763(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;GLYCOSYLATION
9.

"Contribution of the SgIGSF adhesion molecule to survival of cultured mast cells in vivo."
Ito A. , Koma Y. , Watabe K. , Jippo T. , Wakayama T. , Iseki S. , Kitamura Y.
Biochem. Biophys. Res. Commun.319:200-206(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."
Boles K.S. , Barchet W. , Diacovo T. , Cella M. , Colonna M.
Blood106:779-786(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CADM1
11.

"Distribution of RA175/TSLC1/SynCAM, a member of the immunoglobulin superfamily, in the developing nervous system."
Fujita E. , Urase K. , Soyama A. , Kouroku Y. , Momoi T.
Brain Res. Dev. Brain Res.154:199-209(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule."
Galibert L. , Diemer G.S. , Liu Z. , Johnson R.S. , Smith J.L. , Walzer T. , Comeau M.R. , Rauch C.T. , Wolfson M.F. , Sorensen R.A. , Van der Vuurst de Vries A.-R. , Branstetter D.G. , Koelling R.M. , Scholler J. , Fanslow W.C. , Baum P.R. , Derry J.M. , Yan W.
J. Biol. Chem.280:21955-21964(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRTAM
13.

"MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells."
Kitamura Y.
Novartis Found. Symp.271:4-11(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily."
Fujita E. , Kouroku Y. , Ozeki S. , Tanabe Y. , Toyama Y. , Maekawa M. , Kojima N. , Senoo H. , Toshimori K. , Momoi T.
Mol. Cell. Biol.26:718-726(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
15.

"Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis."
van der Weyden L. , Arends M.J. , Chausiaux O.E. , Ellis P.J. , Lange U.C. , Surani M.A. , Affara N. , Murakami Y. , Adams D.J. , Bradley A.
Mol. Cell. Biol.26:3595-3609(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
16.

"Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule."
Yamada D. , Yoshida M. , Williams Y.N. , Fukami T. , Kikuchi S. , Masuda M. , Maruyama T. , Ohta T. , Nakae D. , Maekawa A. , Kitamura T. , Murakami Y.
Mol. Cell. Biol.26:3610-3624(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
17.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104 AND ASN-116
tissue: Myoblast.
19.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-104; ASN-116; ASN-168; ASN-304; ASN-307 AND ASN-311
20.

"N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion."
Fogel A.I. , Li Y. , Giza J. , Wang Q. , Lam T.T. , Modis Y. , Biederer T.
J. Biol. Chem.285:34864-34874(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-70 AND ASN-104;SUBCELLULAR LOCATION
21.

"The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization."
Cheadle L. , Biederer T.
J. Cell Biol.199:985-1001(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FARP1

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