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Index > Protein center > CA12(Gene name) > Human
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  • CA12 (Gene name),
  • Carbonic anhydrase 12 (Protein name ),  CAH12_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CA12;
    Protein name:
    Carbonic anhydrase 12;
    Alternative:
    Carbonic anhydrase XII(CA-XII);Carbonate dehydratase XII;Tumor antigen HOM-RCC-3.1.3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Reversible hydration of carbon dioxide.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    354
    Sequence:
    50:
    MPRRSLHAAA | VLLLVILKEQ | PSSPAPVNGS | KWTYFGPDGE | NSWSKKYPSC | 
    100:
    GGLLQSPIDL | HSDILQYDAS | LTPLEFQGYN | LSANKQFLLT | NNGHSVKLNL | 
    150:
    PSDMHIQGLQ | SRYSATQLHL | HWGNPNDPHG | SEHTVSGQHF | AAELHIVHYN | 
    200:
    SDLYPDASTA | SNKSEGLAVL | AVLIEMGSFN | PSYDKIFSHL | QHVKYKGQEA | 
    250:
    FVPGFNIEEL | LPERTAEYYR | YRGSLTTPPC | NPTVLWTVFR | NPVQISQEQL | 
    300:
    LALETALYCT | HMDDPSPREM | INNFRQVQKF | DERLVYTSFS | QVQVCTAAGL | 
    350:
    SLGIILSLAL | AGILGICIVV | VVSIWLFRRK | SIKKGDNKGV | IYKPATKMET | 
    354:
    EAHA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    KEGG:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Carbonic anhydrase 12
    MSDS:
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    ELISA Kit for Human Carbonic anhydrase 12
    Cat.:
    E15108h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Carbonic anhydrase 12
    MSDS:
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    CLIA Kit for Human Carbonic anhydrase 12
    Cat.:
    U15108h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Carbonic anhydrase 12
    MSDS:
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    CLIA Kit for Human Carbonic anhydrase 12
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Carbonic anhydrase 12
    Polyclonal Antibody for Human Carbonic anhydrase 12
    Polyclonal Antibody for Human Carbonic anhydrase 12
    Monoclonal Antibody for Human Carbonic anhydrase 12
    Monoclonal Antibody for Human Carbonic anhydrase 12
    Monoclonal Antibody for Human Carbonic anhydrase 12
    Protein for Human Carbonic anhydrase 12
    Protein for Human Carbonic anhydrase 12
    Protein for Human Carbonic anhydrase 12

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers."
      Tuereci O. , Sahin U. , Vollmar E. , Siemer S. , Goettert E. , Seitz G. , Parkkila A.-K. , Shah G.N. , Grubb J.H. , Pfreundschuh M. , Sly W.S.
      Proc. Natl. Acad. Sci. U.S.A.95:7608-7613(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION
      tissue: Renal cell carcinoma.
    2. 2.
      "Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes."
      Ivanov S.V. , Kuzmin I. , Wei M.-H. , Pack S. , Geil L. , Johnson B.E. , Stanbridge E.J. , Lerman M.I.
      Proc. Natl. Acad. Sci. U.S.A.95:12596-12601(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lung.
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Trachea.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Eye.
      tissue: Kidney.
    6. 6.
      "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
      Koehler K. , Hillebrecht A. , Schulze Wischeler J. , Innocenti A. , Heine A. , Supuran C.T. , Klebe G.
      Angew. Chem. Int. Ed. Engl.46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    7. 7.
      "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
      Temperini C. , Innocenti A. , Guerri A. , Scozzafava A. , Rusconi S. , Supuran C.T.
      Bioorg. Med. Chem. Lett.17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    8. 8.
      "Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II."
      Srivastava D.K. , Jude K.M. , Banerjee A.L. , Haldar M. , Manokaran S. , Kooren J. , Mallik S. , Christianson D.W.
      J. Am. Chem. Soc.129:5528-5537(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    9. 9.
      "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
      Crocetti L. , Maresca A. , Temperini C. , Hall R.A. , Scozzafava A. , Muehlschlegel F.A. , Supuran C.T.
      Bioorg. Med. Chem. Lett.19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    10. 10.
      "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
      Maresca A. , Temperini C. , Vu H. , Pham N.B. , Poulsen S.-A. , Scozzafava A. , Quinn R.J. , Supuran C.T.
      J. Am. Chem. Soc.131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    11. 11.
      "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
      Di Fiore A. , Monti S.M. , Hilvo M. , Parkkila S. , Romano V. , Scaloni A. , Pedone C. , Scozzafava A. , Supuran C.T. , De Simone G.
      Proteins74:164-175(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
    12. 12.
      "Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells."
      Whittington D.A. , Waheed A. , Ulmasov B. , Shah G.N. , Grubb J.H. , Sly W.S. , Christianson D.W.
      Proc. Natl. Acad. Sci. U.S.A.98:9545-9550(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 30-291 IN COMPLEX WITH ZINC ION AND THE INHIBITOR ACETAZOLAMIDE;DISULFIDE BOND;SUBUNIT
    13. 13.
      "Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII."
      Feldshtein M. , Elkrinawi S. , Yerushalmi B. , Marcus B. , Vullo D. , Romi H. , Ofir R. , Landau D. , Sivan S. , Supuran C.T. , Birk O.S.
      Am. J. Hum. Genet.87:713-720(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HCHLH LYS-143
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