CA4 ELISA Kit for Human(Homo sapiens) | EIAab.comCA4 ELISA Kit for Human(Homo sapiens)

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CA4 (Gene name),

Carbonic anhydrase 4 (Protein name ), CAH4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CA4;

Protein name:

Carbonic anhydrase 4;

Alternative:

Carbonic anhydrase IV(CA-IV);Carbonate dehydratase IV;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SLC4A4.

Function:

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.

Subcellular Location:

Cell membrane Lipid-anchor GPI-anchor

Protein Attributes:

Sequence length:

312

Sequence:

50:

100:

150:

200:

250:

300:

312:

PMLACLLAGF | LR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

114760

KEGG:

hsa:762

SMR:

P22748

String:

P22748

STRING:

9606.ENSP00000300900

UniGene:

Hs.89485

Pfam:

PF00194

Uniprot:

P22748

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ELISA Kit for Human Carbonic anhydrase 4

Cat.:

E1110h

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Manual:

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96T

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ELISA Kit for Human Carbonic anhydrase 4

Cat.:

E1110r

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MSDS:

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Packing:

96T

ELISA Kit for Human Carbonic anhydrase 4

Cat.:

E1110b

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Packing:

96T

ELISA Kit for Human Carbonic anhydrase 4

Cat.:

E1110m

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MSDS:

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Packing:

96T

ELISA Kit for Human Carbonic anhydrase 4

MSDS:

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CLIA Kit for Human Carbonic anhydrase 4

Cat.:

U1110b

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Packing:

96T

CLIA Kit for Human Carbonic anhydrase 4

Cat.:

U1110m

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MSDS:

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Packing:

96T

CLIA Kit for Human Carbonic anhydrase 4

Cat.:

U1110h

Price:

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Human Carbonic anhydrase 4

MSDS:

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CLIA Kit for Human Carbonic anhydrase 4

Cat.:

U1110r

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Packing:

96T

Polyclonal Antibody for Human Carbonic anhydrase 4

Cat.:

P1110Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Carbonic anhydrase 4

Cat.:

P1110Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Carbonic anhydrase 4

Cat.:

P1110Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Carbonic anhydrase 4

Protein for Human Carbonic anhydrase 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes."
Okuyama T. , Sato S. , Zhu X.L. , Waheed A. , Sly W.S.
Proc. Natl. Acad. Sci. U.S.A.89:1315-1319(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q."
Okuyama T. , Batanian J.R. , Sly W.S.
Genomics16:678-684(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
tissue: Placenta.
8.

"Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney."
Zhu X.L. , Sly W.S.
J. Biol. Chem.265:8795-8801(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-35; 113-123 AND 233-239
tissue: Lung.
9.

"Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds."
Waheed A. , Okuyama T. , Heyduk T. , Sly W.S.
Arch. Biochem. Biophys.333:432-438(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
10.

"Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity."
Okuyama T. , Waheed A. , Kusumoto W. , Zhu X.L. , Sly W.S.
Arch. Biochem. Biophys.320:315-322(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR AT SER-284;MUTAGENESIS OF SER-284
11.

"Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme."
Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
Chemistry12:7057-7066(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
12.

"Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design."
Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
J. Med. Chem.49:3019-3027(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
13.

"Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
Koehler K. , Hillebrecht A. , Schulze Wischeler J. , Innocenti A. , Heine A. , Supuran C.T. , Klebe G.
Angew. Chem. Int. Ed. Engl.46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
14.

"Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV."
Temperini C. , Innocenti A. , Scozzafava A. , Mastrolorenzo A. , Supuran C.T.
Bioorg. Med. Chem. Lett.17:628-635(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
15.

"Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
Temperini C. , Innocenti A. , Guerri A. , Scozzafava A. , Rusconi S. , Supuran C.T.
Bioorg. Med. Chem. Lett.17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
16.

"A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
Crocetti L. , Maresca A. , Temperini C. , Hall R.A. , Scozzafava A. , Muehlschlegel F.A. , Supuran C.T.
Bioorg. Med. Chem. Lett.19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
17.

"Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
Maresca A. , Temperini C. , Vu H. , Pham N.B. , Poulsen S.-A. , Scozzafava A. , Quinn R.J. , Supuran C.T.
J. Am. Chem. Soc.131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
18.

"Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
Di Fiore A. , Monti S.M. , Hilvo M. , Parkkila S. , Romano V. , Scaloni A. , Pedone C. , Scozzafava A. , Supuran C.T. , De Simone G.
Proteins74:164-175(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
19.

"Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution."
Stams T. , Nair S.K. , Okuyama T. , Waheed A. , Sly W.S. , Christianson D.W.
Proc. Natl. Acad. Sci. U.S.A.93:13589-13594(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 19-284 IN COMPLEX WITH ZINC ION
20.

"Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation."
Vernier W.F. , Chong W. , Rewolinski D. , Greasley S. , Pauly T.A. , Shaw M. , Dinh D.M. , Ferre R.A.A. , Meador J.W. III , Nukui S. , Ornelas M. , Paz R.L. , Reyner E.
Bioorg. Med. Chem.18:3307-3319(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 19-284 IN COMPLEX WITH INHIBITORS
21.

"Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration."
Yang Z. , Alvarez B.V. , Chakarova C. , Jiang L. , Karan G. , Frederick J.M. , Zhao Y. , Sauve Y. , Li X. , Zrenner E. , Wissinger B. , Den Hollander A.I. , Katz B. , Baehr W. , Cremers F.P. , Casey J.R. , Bhattacharya S.S. , Zhang K.
Hum. Mol. Genet.14:255-265(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RP17;VARIANTS RP17 TRP-14 AND SER-219;FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH SLC4A4
22.

"Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa."
Alvarez B.V. , Vithana E.N. , Yang Z. , Koh A.H. , Yeung K. , Yong V. , Shandro H.J. , Chen Y. , Kolatkar P. , Palasingam P. , Zhang K. , Aung T. , Casey J.R.
Invest. Ophthalmol. Vis. Sci.48:3459-3468(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC4A4;VARIANT RP17 HIS-69;VARIANT LYS-177;CHARACTERIZATION OF VARIANT RP17 HIS-69
23.

"Screening for the carbonic anhydrase IV gene mutations in Chinese retinitis pigmentosa patients."
Tian Y. , Tang L. , Cui J. , Zhu X.
Curr. Eye Res.35:440-444(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RP17 THR-12

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