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Index > Protein center > CA4(Gene name) > Human
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  • CA4 (Gene name),
  • Carbonic anhydrase 4 (Protein name ),  CAH4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CA4;
    Protein name:
    Carbonic anhydrase 4;
    Alternative:
    Carbonic anhydrase IV(CA-IV);Carbonate dehydratase IV;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SLC4A4.
    Function:
    Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    312
    Sequence:
    50:
    MRMLLALLAL | SAARPSASAE | SHWCYEVQAE | SSNYPCLVPV | KWGGNCQKDR | 
    100:
    QSPINIVTTK | AKVDKKLGRF | FFSGYDKKQT | WTVQNNGHSV | MMLLENKASI | 
    150:
    SGGGLPAPYQ | AKQLHLHWSD | LPYKGSEHSL | DGEHFAMEMH | IVHEKEKGTS | 
    200:
    RNVKEAQDPE | DEIAVLAFLV | EAGTQVNEGF | QPLVEALSNI | PKPEMSTTMA | 
    250:
    ESSLLDLLPK | EEKLRHYFRY | LGSLTTPTCD | EKVVWTVFRE | PIQLHREQIL | 
    300:
    AFSQKLYYDK | EQTVSMKDNV | RPLQQLGQRT | VIKSGAPGRP | LPWALPALLG | 
    312:
    PMLACLLAGF | LR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    SMR:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Carbonic anhydrase 4
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    E1110h
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    96T
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    ELISA Kit for Human Carbonic anhydrase 4
    Cat.:
    E1110r
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    Packing:
    96T
    ELISA Kit for Human Carbonic anhydrase 4
    Cat.:
    E1110b
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    96T
    ELISA Kit for Human Carbonic anhydrase 4
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    E1110m
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    Packing:
    96T
    ELISA Kit for Human Carbonic anhydrase 4
    MSDS:
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    CLIA Kit for Human Carbonic anhydrase 4
    Cat.:
    U1110b
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    Packing:
    96T
    CLIA Kit for Human Carbonic anhydrase 4
    Cat.:
    U1110m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Carbonic anhydrase 4
    Cat.:
    U1110h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Carbonic anhydrase 4
    MSDS:
    Please sign in first.
    CLIA Kit for Human Carbonic anhydrase 4
    Cat.:
    U1110r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Carbonic anhydrase 4
    Polyclonal Antibody for Human Carbonic anhydrase 4
    Cat.:
    P1110Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Carbonic anhydrase 4
    Polyclonal Antibody for Human Carbonic anhydrase 4
    Cat.:
    P1110Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Carbonic anhydrase 4
    Cat.:
    P1110Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Carbonic anhydrase 4
    Monoclonal Antibody for Human Carbonic anhydrase 4
    Monoclonal Antibody for Human Carbonic anhydrase 4
    Monoclonal Antibody for Human Carbonic anhydrase 4
    Monoclonal Antibody for Human Carbonic anhydrase 4
    Protein for Human Carbonic anhydrase 4
    Protein for Human Carbonic anhydrase 4
    Protein for Human Carbonic anhydrase 4
    Protein for Human Carbonic anhydrase 4
    Protein for Human Carbonic anhydrase 4

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    References
    1. 1.
      "Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes."
      Okuyama T. , Sato S. , Zhu X.L. , Waheed A. , Sly W.S.
      Proc. Natl. Acad. Sci. U.S.A.89:1315-1319(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q."
      Okuyama T. , Batanian J.R. , Sly W.S.
      Genomics16:678-684(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Placenta.
    7. 8.
      "Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney."
      Zhu X.L. , Sly W.S.
      J. Biol. Chem.265:8795-8801(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-35; 113-123 AND 233-239
      tissue: Lung.
    8. 9.
      "Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds."
      Waheed A. , Okuyama T. , Heyduk T. , Sly W.S.
      Arch. Biochem. Biophys.333:432-438(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    9. 10.
      "Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity."
      Okuyama T. , Waheed A. , Kusumoto W. , Zhu X.L. , Sly W.S.
      Arch. Biochem. Biophys.320:315-322(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR AT SER-284;MUTAGENESIS OF SER-284
    10. 11.
      "Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme."
      Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
      Chemistry12:7057-7066(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    11. 12.
      "Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design."
      Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
      J. Med. Chem.49:3019-3027(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    12. 13.
      "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
      Koehler K. , Hillebrecht A. , Schulze Wischeler J. , Innocenti A. , Heine A. , Supuran C.T. , Klebe G.
      Angew. Chem. Int. Ed. Engl.46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    13. 14.
      "Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV."
      Temperini C. , Innocenti A. , Scozzafava A. , Mastrolorenzo A. , Supuran C.T.
      Bioorg. Med. Chem. Lett.17:628-635(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    14. 15.
      "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
      Temperini C. , Innocenti A. , Guerri A. , Scozzafava A. , Rusconi S. , Supuran C.T.
      Bioorg. Med. Chem. Lett.17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    15. 16.
      "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
      Crocetti L. , Maresca A. , Temperini C. , Hall R.A. , Scozzafava A. , Muehlschlegel F.A. , Supuran C.T.
      Bioorg. Med. Chem. Lett.19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    16. 17.
      "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
      Maresca A. , Temperini C. , Vu H. , Pham N.B. , Poulsen S.-A. , Scozzafava A. , Quinn R.J. , Supuran C.T.
      J. Am. Chem. Soc.131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    17. 18.
      "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
      Di Fiore A. , Monti S.M. , Hilvo M. , Parkkila S. , Romano V. , Scaloni A. , Pedone C. , Scozzafava A. , Supuran C.T. , De Simone G.
      Proteins74:164-175(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
    18. 19.
      "Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution."
      Stams T. , Nair S.K. , Okuyama T. , Waheed A. , Sly W.S. , Christianson D.W.
      Proc. Natl. Acad. Sci. U.S.A.93:13589-13594(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 19-284 IN COMPLEX WITH ZINC ION
    19. 20.
      "Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation."
      Vernier W.F. , Chong W. , Rewolinski D. , Greasley S. , Pauly T.A. , Shaw M. , Dinh D.M. , Ferre R.A.A. , Meador J.W. III , Nukui S. , Ornelas M. , Paz R.L. , Reyner E.
      Bioorg. Med. Chem.18:3307-3319(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 19-284 IN COMPLEX WITH INHIBITORS
    20. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RP17;VARIANTS RP17 TRP-14 AND SER-219;FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH SLC4A4
    21. 22.
      "Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa."
      Alvarez B.V. , Vithana E.N. , Yang Z. , Koh A.H. , Yeung K. , Yong V. , Shandro H.J. , Chen Y. , Kolatkar P. , Palasingam P. , Zhang K. , Aung T. , Casey J.R.
      Invest. Ophthalmol. Vis. Sci.48:3459-3468(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC4A4;VARIANT RP17 HIS-69;VARIANT LYS-177;CHARACTERIZATION OF VARIANT RP17 HIS-69
    22. 23.
      "Screening for the carbonic anhydrase IV gene mutations in Chinese retinitis pigmentosa patients."
      Tian Y. , Tang L. , Cui J. , Zhu X.
      Curr. Eye Res.35:440-444(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RP17 THR-12
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