Protein name:
Carbonic anhydrase 9 ;
Alternative:
Carbonic anhydrase IX (CA-IX;CAIX) ;Carbonate dehydratase IX ;P54/58N ;Membrane antigen MN ;pMW1 ;Renal cell carcinoma-associated antigen G250 (RCC-associated antigen G250) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms oligomers linked by disulfide bonds.
Function:
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Subcellular Location:
Nucleus
Nucleus
nucleolus
Cell membrane
Single-pass type I membrane protein
Cell projection
microvillus membrane
Single-pass type I membrane protein
Found on the surface microvilli and in the nucleus, particularly in nucleolus.
Protein Attributes:
50:
MAPLCPSPWL | PLLIPAPAPG | LTVQLLLSLL | LLVPVHPQRL | PRMQEDSPLG |
100:
GGSSGEDDPL | GEEDLPSEED | SPREEDPPGE | EDLPGEEDLP | GEEDLPEVKP |
150:
KSEEEGSLKL | EDLPTVEAPG | DPQEPQNNAH | RDKEGDDQSH | WRYGGDPPWP |
200:
RVSPACAGRF | QSPVDIRPQL | AAFCPALRPL | ELLGFQLPPL | PELRLRNNGH |
250:
SVQLTLPPGL | EMALGPGREY | RALQLHLHWG | AAGRPGSEHT | VEGHRFPAEI |
300:
HVVHLSTAFA | RVDEALGRPG | GLAVLAAFLE | EGPEENSAYE | QLLSRLEEIA |
350:
EEGSETQVPG | LDISALLPSD | FSRYFQYEGS | LTTPPCAQGV | IWTVFNQTVM |
400:
LSAKQLHTLS | DTLWGPGDSR | LQLNFRATQP | LNGRVIEASF | PAGVDSSPRA |
450:
AEPVQLNSCL | AAGDILALVF | GLLFAVTSVA | FLVQMRRQHR | RGTKGGVSYR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Carbonic anhydrase 9
ELISA Kit for Human Carbonic anhydrase 9
CLIA Kit for Human Carbonic anhydrase 9
CLIA Kit for Human Carbonic anhydrase 9
Polyclonal Antibody for Human Carbonic anhydrase 9
Polyclonal Antibody for Human Carbonic anhydrase 9
Monoclonal Antibody for Human Carbonic anhydrase 9
Monoclonal Antibody for Human Carbonic anhydrase 9
Protein for Human Carbonic anhydrase 9
Protein for Human Carbonic anhydrase 9
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment."
Pastorek J.
,
Pastorekova S.
,
Callebaut I.
,
Mornon J.-P.
,
Zelnik V.
,
Opavsky R.
,
Zat'Ovicova M.
,
Liao S.
,
Portetelle D.
,
Stanbridge E.J.
,
Zavada J.
,
Burny A.
,
Kettmann R.
Oncogene9:2877-2888(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;VARIANT MET-33
tissue :
Carcinoma .
2.
"Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250."
Grabmaier K.
,
Vissers J.L.M.
,
De Weijert M.C.A.
,
Oosterwijk-Wakka J.C.
,
Van Bokhoven A.
,
Brakenhoff R.H.
,
Noessner E.
,
Mulders P.A.
,
Merkx G.
,
Figdor C.G.
,
Adema G.J.
,
Oosterwijk E.
Int. J. Cancer85:865-870(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Renal cell carcinoma .
3.
"DNA sequence and analysis of human chromosome 9."
Humphray S.J.
,
Oliver K.
,
Hunt A.R.
,
Plumb R.W.
,
Loveland J.E.
,
Howe K.L.
,
Andrews T.D.
,
Searle S.
,
Hunt S.E.
,
Scott C.E.
,
Jones M.C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Babbage S.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Barker D.J.
,
Barlow K.F.
,
Bates K.
,
Beasley H.
,
Beasley O.
,
Bird C.P.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.
,
Burrill W.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Chen Y.
,
Clarke G.
,
Clark S.Y.
,
Clee C.M.
,
Clegg S.
,
Collier R.E.
,
Corby N.
,
Crosier M.
,
Cummings A.T.
,
Davies J.
,
Dhami P.
,
Dunn M.
,
Dutta I.
,
Dyer L.W.
,
Earthrowl M.E.
,
Faulkner L.
,
Fleming C.J.
,
Frankish A.
,
Frankland J.A.
,
French L.
,
Fricker D.G.
,
Garner P.
,
Garnett J.
,
Ghori J.
,
Gilbert J.G.R.
,
Glison C.
,
Grafham D.V.
,
Gribble S.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Guy J.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Harrison E.S.I.
,
Hart E.A.
,
Heath P.D.
,
Henderson C.D.
,
Hopkins B.L.
,
Howard P.J.
,
Howden P.J.
,
Huckle E.
,
Johnson C.
,
Johnson D.
,
Joy A.A.
,
Kay M.
,
Keenan S.
,
Kershaw J.K.
,
Kimberley A.M.
,
King A.
,
Knights A.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leongamornlert D.A.
,
Leversha M.
,
Lloyd C.
,
Lloyd D.M.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
McLaren S.
,
McLay K.E.
,
McMurray A.
,
Milne S.
,
Nickerson T.
,
Nisbett J.
,
Nordsiek G.
,
Pearce A.V.
,
Peck A.I.
,
Porter K.M.
,
Pandian R.
,
Pelan S.
,
Phillimore B.
,
Povey S.
,
Ramsey Y.
,
Rand V.
,
Scharfe M.
,
Sehra H.K.
,
Shownkeen R.
,
Sims S.K.
,
Skuce C.D.
,
Smith M.
,
Steward C.A.
,
Swarbreck D.
,
Sycamore N.
,
Tester J.
,
Thorpe A.
,
Tracey A.
,
Tromans A.
,
Thomas D.W.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
Whitehead S.L.
,
Willey D.L.
,
Williams S.A.
,
Wilming L.
,
Wray P.W.
,
Young L.
,
Ashurst J.L.
,
Coulson A.
,
Blocker H.
,
Durbin R.M.
,
Sulston J.E.
,
Hubbard T.
,
Jackson M.J.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
,
Dunham I.
more...
Nature429:369-374(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-33
tissue :
Colon .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 38-52
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-449
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION
12.
"Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes."
Hilvo M.
,
Baranauskiene L.
,
Salzano A.M.
,
Scaloni A.
,
Matulis D.
,
Innocenti A.
,
Scozzafava A.
,
Monti S.M.
,
Di Fiore A.
,
De Simone G.
,
Lindfors M.
,
Janis J.
,
Valjakka J.
,
Pastorekova S.
,
Pastorek J.
,
Kulomaa M.S.
,
Nordlund H.R.
,
Supuran C.T.
,
Parkkila S.
more...
J. Biol. Chem.283:27799-27809(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT;INDUCTION;GLYCOSYLATION AT THR-115 AND ASN-346;DISULFIDE BONDS
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION
16.
"Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations."
Kral V.
,
Mader P.
,
Collard R.
,
Fabry M.
,
Horejsi M.
,
Rezacova P.
,
Kozisek M.
,
Zavada J.
,
Sedlacek J.
,
Rulisek L.
,
Brynda J.
Proteins71:1275-1287(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 83-91 IN COMPLEX WITH SPECIFIC ANTIBODIES
17.
"Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX."
Alterio V.
,
Hilvo M.
,
Di Fiore A.
,
Supuran C.T.
,
Pan P.
,
Parkkila S.
,
Scaloni A.
,
Pastorek J.
,
Pastorekova S.
,
Pedone C.
,
Scozzafava A.
,
Monti S.M.
,
De Simone G.
Proc. Natl. Acad. Sci. U.S.A.106:16233-16238(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 137-391 IN COMPLEX WITH ZINC ION AND THE INHIBITOR ACETAZOLAMIDE;GLYCOSYLATION AT ASN-346;DISULFIDE BOND;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES