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Index > Protein center > CA9(Gene name) > Human
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  • CA9 (Gene name),
  • Carbonic anhydrase 9 (Protein name ),  CAH9_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CA9(G250;MN);
    Protein name:
    Carbonic anhydrase 9;
    Alternative:
    Carbonic anhydrase IX(CA-IX;CAIX);Carbonate dehydratase IX;P54/58N;Membrane antigen MN;pMW1;Renal cell carcinoma-associated antigen G250(RCC-associated antigen G250);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms oligomers linked by disulfide bonds.
    Function:
    Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
    Subcellular Location:
    Nucleus Nucleus nucleolus Cell membrane Single-pass type I membrane protein Cell projection microvillus membrane Single-pass type I membrane protein Found on the surface microvilli and in the nucleus, particularly in nucleolus.
    Protein Attributes:
    Sequence length:
    459
    Sequence:
    50:
    MAPLCPSPWL | PLLIPAPAPG | LTVQLLLSLL | LLVPVHPQRL | PRMQEDSPLG | 
    100:
    GGSSGEDDPL | GEEDLPSEED | SPREEDPPGE | EDLPGEEDLP | GEEDLPEVKP | 
    150:
    KSEEEGSLKL | EDLPTVEAPG | DPQEPQNNAH | RDKEGDDQSH | WRYGGDPPWP | 
    200:
    RVSPACAGRF | QSPVDIRPQL | AAFCPALRPL | ELLGFQLPPL | PELRLRNNGH | 
    250:
    SVQLTLPPGL | EMALGPGREY | RALQLHLHWG | AAGRPGSEHT | VEGHRFPAEI | 
    300:
    HVVHLSTAFA | RVDEALGRPG | GLAVLAAFLE | EGPEENSAYE | QLLSRLEEIA | 
    350:
    EEGSETQVPG | LDISALLPSD | FSRYFQYEGS | LTTPPCAQGV | IWTVFNQTVM | 
    400:
    LSAKQLHTLS | DTLWGPGDSR | LQLNFRATQP | LNGRVIEASF | PAGVDSSPRA | 
    450:
    AEPVQLNSCL | AAGDILALVF | GLLFAVTSVA | FLVQMRRQHR | RGTKGGVSYR | 
    459:
    PAEVAETGA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    SMR:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Carbonic anhydrase 9
    Cat.:
    E1426h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Carbonic anhydrase 9
    Cat.:
    E1426m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Carbonic anhydrase 9
    Cat.:
    U1426h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Carbonic anhydrase 9
    Cat.:
    U1426m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Carbonic anhydrase 9
    Cat.:
    P1426Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Carbonic anhydrase 9
    Cat.:
    P1426Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Carbonic anhydrase 9
    Monoclonal Antibody for Human Carbonic anhydrase 9
    Protein for Human Carbonic anhydrase 9
    Protein for Human Carbonic anhydrase 9

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment."
      Pastorek J. , Pastorekova S. , Callebaut I. , Mornon J.-P. , Zelnik V. , Opavsky R. , Zat'Ovicova M. , Liao S. , Portetelle D. , Stanbridge E.J. , Zavada J. , Burny A. , Kettmann R.
      Oncogene9:2877-2888(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;VARIANT MET-33
      tissue: Carcinoma.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Renal cell carcinoma.
    3. 3.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-33
      tissue: Colon.
    6. 6.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 38-52
    7. 7.
      "A novel quasi-viral agent, MaTu, is a two-component system."
      Pastorekova S. , Zavadova Z. , Kostal M. , Babusikova O. , Zavada J.
      Virology187:620-626(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    8. 8.
      "Expression of MaTu-MN protein in human tumor cultures and in clinical specimens."
      Zavada J. , Zavadova Z. , Pastorekova S. , Ciampor F. , Pastorek J. , Zelnik V.
      Int. J. Cancer54:268-274(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "The role of carbonic anhydrase IX overexpression in kidney cancer."
      Dorai T. , Sawczuk I.S. , Pastorek J. , Wiernik P.H. , Dutcher J.P.
      Eur. J. Cancer41:2935-2947(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-449
    10. 10.
      "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
      Koehler K. , Hillebrecht A. , Schulze Wischeler J. , Innocenti A. , Heine A. , Supuran C.T. , Klebe G.
      Angew. Chem. Int. Ed. Engl.46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    11. 11.
      "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
      Temperini C. , Innocenti A. , Guerri A. , Scozzafava A. , Rusconi S. , Supuran C.T.
      Bioorg. Med. Chem. Lett.17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INDUCTION;GLYCOSYLATION AT THR-115 AND ASN-346;DISULFIDE BONDS
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
      Crocetti L. , Maresca A. , Temperini C. , Hall R.A. , Scozzafava A. , Muehlschlegel F.A. , Supuran C.T.
      Bioorg. Med. Chem. Lett.19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    15. 15.
      "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
      Maresca A. , Temperini C. , Vu H. , Pham N.B. , Poulsen S.-A. , Scozzafava A. , Quinn R.J. , Supuran C.T.
      J. Am. Chem. Soc.131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    16. 16.
      "Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations."
      Kral V. , Mader P. , Collard R. , Fabry M. , Horejsi M. , Rezacova P. , Kozisek M. , Zavada J. , Sedlacek J. , Rulisek L. , Brynda J.
      Proteins71:1275-1287(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 83-91 IN COMPLEX WITH SPECIFIC ANTIBODIES
    17. 17.
      "Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX."
      Alterio V. , Hilvo M. , Di Fiore A. , Supuran C.T. , Pan P. , Parkkila S. , Scaloni A. , Pastorek J. , Pastorekova S. , Pedone C. , Scozzafava A. , Monti S.M. , De Simone G.
      Proc. Natl. Acad. Sci. U.S.A.106:16233-16238(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 137-391 IN COMPLEX WITH ZINC ION AND THE INHIBITOR ACETAZOLAMIDE;GLYCOSYLATION AT ASN-346;DISULFIDE BOND;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES
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