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Index > Protein center > Capn1(Gene name) > Rat
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  • Capn1 (Gene name),
  • Calpain-1 catalytic subunit (Protein name ),  CAN1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Capn1(Cls1);
    Protein name:
    Calpain-1 catalytic subunit;
    Alternative:
    Calpain mu-type;Calcium-activated neutral proteinase 1(CANP 1);Micromolar-calpain(muCANP);Calpain-1 large subunit;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
    Function:
    Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
    Subcellular Location:
    Cytoplasm Cell membrane Translocates to the plasma membrane upon Ca(2+) binding.
    Protein Attributes:
    Sequence length:
    713
    Sequence:
    50:
    MAEELITPVY | CTGVSAQVQK | QRDKELGLGR | HENAIKYLGQ | DYENLRARCL | 
    100:
    QNGVLFQDDA | FPPVSHSLGF | KELGPNSSKT | YGIKWKRPTE | LLSNPQFIVD | 
    150:
    GATRTDICQG | ALGDCWLLAA | IASLTLNETI | LHRVVPYGQS | FQEGYAGIFH | 
    200:
    FQLWQFGEWV | DVVVDDLLPT | KDGKLVFVHS | AQGNEFWSAL | LEKAYAKVNG | 
    250:
    SYEALSGGCT | SEAFEDFTGG | VTEWYDLQKA | PSDLYQIILK | ALERGSLLGC | 
    300:
    SINISDIRDL | EAITFKNLVR | GHAYSVTDAK | QVTYQGQRVN | LIRMRNPWGE | 
    350:
    VEWKGPWSDN | SYEWNKVDPY | EREQLRVKME | DGEFWMSFRD | FIREFTKLEI | 
    400:
    CNLTPDALKS | RTLRNWNTTF | YEGTWRRGST | AGGCRNYPAT | FWVNPQFKIR | 
    450:
    LEEVDDADDY | DSRESGCSFL | LALMQKHRRR | ERRFGRDMET | IGFAVYQVPR | 
    500:
    ELAGQPVHLK | RDFFLANASR | AQSEHFINLR | EVSNRIRLPP | GEYIVVPSTF | 
    550:
    EPNKEGDFLL | RFFSEKKAGT | QELDDQIQAN | LPDEKVLSEE | EIDDNFKTLF | 
    600:
    SKLAGDDMEI | SVKELQTILN | RIISKHKDLR | TNGFSLESCR | SMVNLMDRDG | 
    650:
    NGKLGLVEFN | ILWNRIRNYL | TIFRKFDLDK | SGSMSAYEMR | MAIEAAGFKL | 
    700:
    NKKLHELIIT | RYSEPDLAVD | FDNFVCCLVR | LETMFRFFKI | LDTDLDGVVT | 
    713:
    FDLFKWLQLT | MFA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Calpain-1 catalytic subunit
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    E2248r
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    ELISA Kit for Rat Calpain-1 catalytic subunit
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    E2248h
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    ELISA Kit for Rat Calpain-1 catalytic subunit
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    E2248p
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    ELISA Kit for Rat Calpain-1 catalytic subunit
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    ELISA Kit for Rat Calpain-1 catalytic subunit
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    E2248m
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    96T
    ELISA Kit for Rat Calpain-1 catalytic subunit
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    E2248b
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    Packing:
    96T
    CLIA Kit for Rat Calpain-1 catalytic subunit
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    U2248r
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    Packing:
    96T
    CLIA Kit for Rat Calpain-1 catalytic subunit
    Cat.:
    U2248b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Calpain-1 catalytic subunit
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Calpain-1 catalytic subunit
    Cat.:
    U2248p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Calpain-1 catalytic subunit
    Cat.:
    U2248h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Calpain-1 catalytic subunit
    Cat.:
    U2248m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Calpain-1 catalytic subunit
    Polyclonal Antibody for Rat Calpain-1 catalytic subunit
    Cat.:
    P2248Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Calpain-1 catalytic subunit
    Cat.:
    P2248Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Calpain-1 catalytic subunit
    Cat.:
    P2248Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Calpain-1 catalytic subunit
    Polyclonal Antibody for Rat Calpain-1 catalytic subunit
    Monoclonal Antibody for Rat Calpain-1 catalytic subunit
    Monoclonal Antibody for Rat Calpain-1 catalytic subunit
    Monoclonal Antibody for Rat Calpain-1 catalytic subunit
    Monoclonal Antibody for Rat Calpain-1 catalytic subunit
    Monoclonal Antibody for Rat Calpain-1 catalytic subunit
    Monoclonal Antibody for Rat Calpain-1 catalytic subunit
    Protein for Rat Calpain-1 catalytic subunit
    Protein for Rat Calpain-1 catalytic subunit
    Protein for Rat Calpain-1 catalytic subunit
    Protein for Rat Calpain-1 catalytic subunit
    Protein for Rat Calpain-1 catalytic subunit
    Protein for Rat Calpain-1 catalytic subunit

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human."
      Sorimachi H. , Amano S. , Ishiura S. , Suzuki K.
      Biochim. Biophys. Acta1309:37-41(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    3. 3.
      "A Ca(2+) switch aligns the active site of calpain."
      Moldoveanu T. , Hosfield C.M. , Lim D. , Elce J.S. , Jia Z. , Davies P.L.
      Cell108:649-660(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) OF 27-356;CALCIUM-BINDING REGIONS
    4. 4.
      "Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement."
      Pal G.P. , De Veyra T. , Elce J.S. , Jia Z.
      Structure11:1521-1526(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 60-647
    5. 5.
      "Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site."
      Moldoveanu T. , Campbell R.L. , Cuerrier D. , Davies P.L.
      J. Mol. Biol.343:1313-1326(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 27-356 IN COMPLEX WITH INHIBITORS;CALCIUM-BINDING REGIONS
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