Gene name:
CAPN2 (CANPL2) ;
Protein name:
Calpain-2 catalytic subunit ;
Alternative:
Calpain M-type ;Calcium-activated neutral proteinase 2 (CANP 2) ;Calpain-2 large subunit ;Calpain large polypeptide L2 ;Millimolar-calpain (M-calpain) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
Function:
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Subcellular Location:
Cytoplasm
Cell membrane
Translocates to the plasma membrane upon Ca(2+) binding.
Protein Attributes:
50:
MAGIAAKLAK | DREAAEGLGS | HDRAIKYLNQ | DYEALRNECL | EAGTLFQDPS |
100:
FPAIPSALGF | KELGPYSSKT | RGIEWKRPTE | ICADPQFIIG | GATRTDICQG |
150:
ALGDCWLLAA | IASLTLNEEI | LARVVPLNQS | FQENYAGIFH | FQFWQYGEWV |
200:
EVVVDDRLPT | KDGELLFVHS | AEGSEFWSAL | LEKAYAKING | CYEALSGGAT |
250:
TEGFEDFTGG | IAEWYELKKP | PPNLFKIIQK | ALQKGSLLGC | SIDITSAADS |
300:
EAITFQKLVK | GHAYSVTGAE | EVESNGSLQK | LIRIRNPWGE | VEWTGRWNDN |
350:
CPSWNTIDPE | ERERLTRRHE | DGEFWMSFSD | FLRHYSRLEI | CNLTPDTLTS |
400:
DTYKKWKLTK | MDGNWRRGST | AGGCRNYPNT | FWMNPQYLIK | LEEEDEDEED |
450:
GESGCTFLVG | LIQKHRRRQR | KMGEDMHTIG | FGIYEVPEEL | SGQTNIHLSK |
500:
NFFLTNRARE | RSDTFINLRE | VLNRFKLPPG | EYILVPSTFE | PNKDGDFCIR |
550:
VFSEKKADYQ | AVDDEIEANL | EEFDISEDDI | DDGFRRLFAQ | LAGEDAEISA |
600:
FELQTILRRV | LAKRQDIKSD | GFSIETCKIM | VDMLDSDGSG | KLGLKEFYIL |
650:
WTKIQKYQKI | YREIDVDRSG | TMNSYEMRKA | LEEAGFKMPC | QLHQVIVARF |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Pig
Bovine
Chicken
Rabbit
Mouse
ELISA Kit for Human Calpain-2 catalytic subunit
ELISA Kit for Human Calpain-2 catalytic subunit
ELISA Kit for Human Calpain-2 catalytic subunit
ELISA Kit for Human Calpain-2 catalytic subunit
ELISA Kit for Human Calpain-2 catalytic subunit
ELISA Kit for Human Calpain-2 catalytic subunit
ELISA Kit for Human Calpain-2 catalytic subunit
CLIA Kit for Human Calpain-2 catalytic subunit
CLIA Kit for Human Calpain-2 catalytic subunit
CLIA Kit for Human Calpain-2 catalytic subunit
CLIA Kit for Human Calpain-2 catalytic subunit
CLIA Kit for Human Calpain-2 catalytic subunit
CLIA Kit for Human Calpain-2 catalytic subunit
CLIA Kit for Human Calpain-2 catalytic subunit
Polyclonal Antibody for Human Calpain-2 catalytic subunit
Polyclonal Antibody for Human Calpain-2 catalytic subunit
Polyclonal Antibody for Human Calpain-2 catalytic subunit
Polyclonal Antibody for Human Calpain-2 catalytic subunit
Polyclonal Antibody for Human Calpain-2 catalytic subunit
Polyclonal Antibody for Human Calpain-2 catalytic subunit
Polyclonal Antibody for Human Calpain-2 catalytic subunit
Monoclonal Antibody for Human Calpain-2 catalytic subunit
Monoclonal Antibody for Human Calpain-2 catalytic subunit
Monoclonal Antibody for Human Calpain-2 catalytic subunit
Monoclonal Antibody for Human Calpain-2 catalytic subunit
Monoclonal Antibody for Human Calpain-2 catalytic subunit
Monoclonal Antibody for Human Calpain-2 catalytic subunit
Monoclonal Antibody for Human Calpain-2 catalytic subunit
Protein for Human Calpain-2 catalytic subunit
Protein for Human Calpain-2 catalytic subunit
Protein for Human Calpain-2 catalytic subunit
Protein for Human Calpain-2 catalytic subunit
Protein for Human Calpain-2 catalytic subunit
Protein for Human Calpain-2 catalytic subunit
Protein for Human Calpain-2 catalytic subunit
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-22
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-22
tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLU-22; GLY-68; ARG-476; GLN-521; GLN-568 AND GLN-677
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Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-22
tissue :
Pancreas .
tissue :
Placenta .
tissue :
Skin .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79;VARIANTS GLU-22 AND GLY-68
tissue :
Lymph node .
8.
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Cited for : PROTEIN SEQUENCE OF 2-12
tissue :
Platelet .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
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Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
11.
"The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium."
Strobl S.
,
Fernandez-Catalan C.
,
Braun M.
,
Huber R.
,
Masumoto H.
,
Nakagawa K.
,
Irie A.
,
Sorimachi H.
,
Bourenkow G.
,
Bartunik H.
,
Suzuki K.
,
Bode W.
Proc. Natl. Acad. Sci. U.S.A.97:588-592(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] GLU-22;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]