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Index > Protein center > CAPN2(Gene name) > Human
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  • CAPN2 (Gene name),
  • Calpain-2 catalytic subunit (Protein name ),  CAN2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CAPN2(CANPL2);
    Protein name:
    Calpain-2 catalytic subunit;
    Alternative:
    Calpain M-type;Calcium-activated neutral proteinase 2(CANP 2);Calpain-2 large subunit;Calpain large polypeptide L2;Millimolar-calpain(M-calpain);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
    Function:
    Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
    Subcellular Location:
    Cytoplasm Cell membrane Translocates to the plasma membrane upon Ca(2+) binding.
    Protein Attributes:
    Sequence length:
    700
    Sequence:
    50:
    MAGIAAKLAK | DREAAEGLGS | HDRAIKYLNQ | DYEALRNECL | EAGTLFQDPS | 
    100:
    FPAIPSALGF | KELGPYSSKT | RGIEWKRPTE | ICADPQFIIG | GATRTDICQG | 
    150:
    ALGDCWLLAA | IASLTLNEEI | LARVVPLNQS | FQENYAGIFH | FQFWQYGEWV | 
    200:
    EVVVDDRLPT | KDGELLFVHS | AEGSEFWSAL | LEKAYAKING | CYEALSGGAT | 
    250:
    TEGFEDFTGG | IAEWYELKKP | PPNLFKIIQK | ALQKGSLLGC | SIDITSAADS | 
    300:
    EAITFQKLVK | GHAYSVTGAE | EVESNGSLQK | LIRIRNPWGE | VEWTGRWNDN | 
    350:
    CPSWNTIDPE | ERERLTRRHE | DGEFWMSFSD | FLRHYSRLEI | CNLTPDTLTS | 
    400:
    DTYKKWKLTK | MDGNWRRGST | AGGCRNYPNT | FWMNPQYLIK | LEEEDEDEED | 
    450:
    GESGCTFLVG | LIQKHRRRQR | KMGEDMHTIG | FGIYEVPEEL | SGQTNIHLSK | 
    500:
    NFFLTNRARE | RSDTFINLRE | VLNRFKLPPG | EYILVPSTFE | PNKDGDFCIR | 
    550:
    VFSEKKADYQ | AVDDEIEANL | EEFDISEDDI | DDGFRRLFAQ | LAGEDAEISA | 
    600:
    FELQTILRRV | LAKRQDIKSD | GFSIETCKIM | VDMLDSDGSG | KLGLKEFYIL | 
    650:
    WTKIQKYQKI | YREIDVDRSG | TMNSYEMRKA | LEEAGFKMPC | QLHQVIVARF | 
    700:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    Pfam:
    KEGG:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    E2249r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    E2249h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Calpain-2 catalytic subunit
    MSDS:
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    ELISA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    E2249b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    E2249c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Calpain-2 catalytic subunit
    MSDS:
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    ELISA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    E2249m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    U2249h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    U2249c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    U2249b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    U2249m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calpain-2 catalytic subunit
    MSDS:
    Please sign in first.
    CLIA Kit for Human Calpain-2 catalytic subunit
    MSDS:
    Please sign in first.
    CLIA Kit for Human Calpain-2 catalytic subunit
    Cat.:
    U2249r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Calpain-2 catalytic subunit
    Polyclonal Antibody for Human Calpain-2 catalytic subunit
    Cat.:
    P2249Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calpain-2 catalytic subunit
    Polyclonal Antibody for Human Calpain-2 catalytic subunit
    Cat.:
    P2249Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calpain-2 catalytic subunit
    Polyclonal Antibody for Human Calpain-2 catalytic subunit
    Polyclonal Antibody for Human Calpain-2 catalytic subunit
    Cat.:
    P2249Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Calpain-2 catalytic subunit
    Monoclonal Antibody for Human Calpain-2 catalytic subunit
    Monoclonal Antibody for Human Calpain-2 catalytic subunit
    Monoclonal Antibody for Human Calpain-2 catalytic subunit
    Monoclonal Antibody for Human Calpain-2 catalytic subunit
    Monoclonal Antibody for Human Calpain-2 catalytic subunit
    Monoclonal Antibody for Human Calpain-2 catalytic subunit
    Protein for Human Calpain-2 catalytic subunit
    Protein for Human Calpain-2 catalytic subunit
    Protein for Human Calpain-2 catalytic subunit
    Protein for Human Calpain-2 catalytic subunit
    Protein for Human Calpain-2 catalytic subunit
    Protein for Human Calpain-2 catalytic subunit
    Protein for Human Calpain-2 catalytic subunit

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease."
      Imajoh S. , Aoki K. , Ohno S. , Emori Y. , Kawasaki H. , Sugihara H. , Suzuki K.
      Biochemistry27:8122-8128(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-22
    2. 2.
      "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
      Ye Z. , Connor J.R.
      Biochem. Biophys. Res. Commun.275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-22
      tissue: Astrocytoma.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      NIEHS SNPs program
      Submitted (2004-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLU-22; GLY-68; ARG-476; GLN-521; GLN-568 AND GLN-677
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-22
      tissue: Pancreas.
      tissue: Placenta.
      tissue: Skin.
    7. 7.
      "Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease."
      Hata A. , Ohno S. , Akita Y. , Suzuki K.
      J. Biol. Chem.264:6404-6411(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79;VARIANTS GLU-22 AND GLY-68
      tissue: Lymph node.
    8. 8.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-12
      tissue: Platelet.
    9. 9.
      "Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease."
      Sanchez-Sanchez F. , Martinez-Redondo F. , Aroca-Aguilar J.D. , Coca-Prados M. , Escribano J.
      J. Biol. Chem.282:27810-27824(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    11. 11.
      "The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium."
      Strobl S. , Fernandez-Catalan C. , Braun M. , Huber R. , Masumoto H. , Nakagawa K. , Irie A. , Sorimachi H. , Bourenkow G. , Bartunik H. , Suzuki K. , Bode W.
      Proc. Natl. Acad. Sci. U.S.A.97:588-592(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-22;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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