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Index > Protein center > Capn6(Gene name) > Mouse
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  • Capn6 (Gene name),
  • Calpain-6 (Protein name ),  CAN6_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Capn6(Capa6);
    Protein name:
    Calpain-6;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).
    Function:
    Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
    Subcellular Location:
    Cytoplasm perinuclear region Cytoplasm cytoskeleton spindle
    Protein Attributes:
    Sequence length:
    641
    Sequence:
    50:
    MGPPLKLFKN | QKYQELKQEC | MKDGRLFCDP | TFLPENDSLF | FNRLLPGKVV | 
    100:
    WKRPQDISDD | PHLIVGNISN | HQLIQGRLGN | KAMISAFSCL | AVQESHWTKA | 
    150:
    IPNHKDQEWD | PRKPEKYAGI | FHFRFWHFGE | WTEVVIDDLL | PTINGDLVFS | 
    200:
    FSTSMNEFWN | ALLEKAYAKL | LGCYEALDGL | TITDIIMDFT | GTLAEIIDMQ | 
    250:
    KGRYTDLVEE | KYKLFGELYK | TFTKGGLICC | SIESPSQEEQ | EVETDWGLLK | 
    300:
    GYTYTMTDIR | KLRLGERLVE | VFSTEKLYMV | RLRNPLGRQE | WSGPWSEISE | 
    350:
    EWQQLTVTDR | KNLGLVMSDD | GEFWMSLEDF | CHNFHKLNVC | RNVNNPVFGR | 
    400:
    KELESVVGCW | TVDDDPLMNR | SGGCYNNRDT | FLQNPQYIFT | VPEDGHKVIM | 
    450:
    SLQQKDLRTY | RRMGRPDNYI | IGFELFKVEM | NRRFRLHHLY | IQERAGTSTY | 
    500:
    IDTRTVFLSK | YLKKGSYVLV | PTMFQHGRTS | EFLLRIFSEV | PVQLRELTLD | 
    550:
    MPKMSCWNLA | RGYPKVVTQI | TVHSAEGLEK | KYANETVNPY | LIIKCGKEEV | 
    600:
    RSPVQKNTVH | AIFDTQAIFY | RRTTDIPIII | QVWNSRKFCD | QFLGQVTLDA | 
    641:
    DPSDCRDLKS | LYLRKKGGPT | AKVKQGHISF | KVISSDDLTE | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Calpain-6
    Cat.:
    E2252h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Calpain-6
    Cat.:
    E2252r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Calpain-6
    Cat.:
    E2252m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Calpain-6
    Cat.:
    U2252r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Calpain-6
    Cat.:
    U2252h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Calpain-6
    Cat.:
    U2252m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Calpain-6
    Cat.:
    P2252Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Calpain-6
    Cat.:
    P2252Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Calpain-6
    Cat.:
    P2252Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Calpain-6
    Monoclonal Antibody for Mouse Calpain-6
    Monoclonal Antibody for Mouse Calpain-6
    Protein for Mouse Calpain-6
    Protein for Mouse Calpain-6
    Protein for Mouse Calpain-6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily."
      Matena K. , Boehm T. , Dear N.T.
      Genomics48:117-120(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Mammary gland.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "Calpain 6 is involved in microtubule stabilization and cytoskeletal organization."
      Tonami K. , Kurihara Y. , Aburatani H. , Uchijima Y. , Asano T. , Kurihara H.
      Mol. Cell. Biol.27:2548-2561(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;FUNCTION;INTERACTION WITH MICROTUBULE;SUBCELLULAR LOCATION
    5. 5.
      "Calpain-6, a target molecule of glucocorticoids, regulates osteoclastic bone resorption via cytoskeletal organization and microtubule acetylation."
      Hong J.M. , Teitelbaum S.L. , Kim T.H. , Ross F.P. , Kim S.Y. , Kim H.J.
      J. Bone Miner. Res.26:657-665(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION
    6. 6.
      "Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1."
      Tonami K. , Kurihara Y. , Arima S. , Nishiyama K. , Uchijima Y. , Asano T. , Sorimachi H. , Kurihara H.
      J. Cell Sci.124:1214-1223(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ARHGEF2
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