Gene name:
NEDD9 (CASL;CASS2) ;
Protein name:
Enhancer of filamentation 1 (hEF1) ;
Alternative:
Cas scaffolding protein family member 2 ;CRK-associated substrate-related protein (CAS-L;CasL) ;Renal carcinoma antigen NY-REN-12 ;Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) ;p105 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with BCAR3 and SH2D3C (By similarity). Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1.
Function:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
Subcellular Location:
Enhancer of filamentation 1 p55
Cytoplasm
cytoskeleton
spindle
Protein Attributes:
50:
MKYKNLMARA | LYDNVPECAE | ELAFRKGDIL | TVIEQNTGGL | EGWWLCSLHG |
100:
RQGIVPGNRV | KLLIGPMQET | ASSHEQPASG | LMQQTFGQQK | LYQVPNPQAA |
150:
PRDTIYQVPP | SYQNQGIYQV | PTGHGTQEQE | VYQVPPSVQR | SIGGTSGPHV |
200:
GKKVITPVRT | GHGYVYEYPS | RYQKDVYDIP | PSHTTQGVYD | IPPSSAKGPV |
250:
FSVPVGEIKP | QGVYDIPPTK | GVYAIPPSAC | RDEAGLREKD | YDFPPPMRQA |
300:
GRPDLRPEGV | YDIPPTCTKP | AGKDLHVKYN | CDIPGAAEPV | ARRHQSLSPN |
350:
HPPPQLGQSV | GSQNDAYDVP | RGVQFLEPPA | ETSEKANPQE | RDGVYDVPLH |
400:
NPPDAKGSRD | LVDGINRLSF | SSTGSTRSNM | STSSTSSKES | SLSASPAQDK |
450:
RLFLDPDTAI | ERLQRLQQAL | EMGVSSLMAL | VTTDWRCYGY | MERHINEIRT |
500:
AVDKVELFLK | EYLHFVKGAV | ANAACLPELI | LHNKMKRELQ | RVEDSHQILS |
550:
QTSHDLNECS | WSLNILAINK | PQNKCDDLDR | FVMVAKTVPD | DAKQLTTTIN |
600:
TNAEALFRPG | PGSLHLKNGP | ESIMNSTEYP | HGGSQGQLLH | PGDHKAQAHN |
650:
KALPPGLSKE | QAPDCSSSDG | SERSWMDDYD | YVHLQGKEEF | ERQQKELLEK |
700:
ENIMKQNKMQ | LEHHQLSQFQ | LLEQEITKPV | ENDISKWKPS | QSLPTTNSGV |
750:
SAQDRQLLCF | YYDQCETHFI | SLLNAIDALF | SCVSSAQPPR | IFVAHSKFVI |
800:
LSAHKLVFIG | DTLTRQVTAQ | DIRNKVMNSS | NQLCEQLKTI | VMATKMAALH |
834:
YPSTTALQEM | VHQVTDLSRN | AQLFKRSLLE | MATF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Human hEF1
Polyclonal Antibody for Human hEF1
Monoclonal Antibody for Human hEF1
Monoclonal Antibody for Human hEF1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Lymphoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Thymus .
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Brain .
tissue :
Lung .
7.
"Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells."
Manie S.N.
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Beck A.R.P.
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Astier A.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYROSINE RESIDUES UPON CD3 CROSS-LINKING
11.
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Renal cell carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TXNL4
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MICAL
15.
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Proc. Natl. Acad. Sci. U.S.A.100:443-448(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-296 AND SER-369
18.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
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,
Lasa M.
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,
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Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
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Cited for : STRUCTURE BY NMR OF 399-563