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Index > Protein center > NEDD9(Gene name) > Human
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  • NEDD9 (Gene name),
  • Enhancer of filamentation 1 (Protein name ),  CASL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NEDD9(CASL;CASS2);
    Protein name:
    Enhancer of filamentation 1(hEF1);
    Alternative:
    Cas scaffolding protein family member 2;CRK-associated substrate-related protein(CAS-L;CasL);Renal carcinoma antigen NY-REN-12;Neural precursor cell expressed developmentally down-regulated protein 9(NEDD-9);p105;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BCAR3 and SH2D3C (By similarity). Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1.
    Function:
    Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
    Subcellular Location:
    Enhancer of filamentation 1 p55 Cytoplasm cytoskeleton spindle
    Protein Attributes:
    Sequence length:
    834
    Sequence:
    50:
    MKYKNLMARA | LYDNVPECAE | ELAFRKGDIL | TVIEQNTGGL | EGWWLCSLHG | 
    100:
    RQGIVPGNRV | KLLIGPMQET | ASSHEQPASG | LMQQTFGQQK | LYQVPNPQAA | 
    150:
    PRDTIYQVPP | SYQNQGIYQV | PTGHGTQEQE | VYQVPPSVQR | SIGGTSGPHV | 
    200:
    GKKVITPVRT | GHGYVYEYPS | RYQKDVYDIP | PSHTTQGVYD | IPPSSAKGPV | 
    250:
    FSVPVGEIKP | QGVYDIPPTK | GVYAIPPSAC | RDEAGLREKD | YDFPPPMRQA | 
    300:
    GRPDLRPEGV | YDIPPTCTKP | AGKDLHVKYN | CDIPGAAEPV | ARRHQSLSPN | 
    350:
    HPPPQLGQSV | GSQNDAYDVP | RGVQFLEPPA | ETSEKANPQE | RDGVYDVPLH | 
    400:
    NPPDAKGSRD | LVDGINRLSF | SSTGSTRSNM | STSSTSSKES | SLSASPAQDK | 
    450:
    RLFLDPDTAI | ERLQRLQQAL | EMGVSSLMAL | VTTDWRCYGY | MERHINEIRT | 
    500:
    AVDKVELFLK | EYLHFVKGAV | ANAACLPELI | LHNKMKRELQ | RVEDSHQILS | 
    550:
    QTSHDLNECS | WSLNILAINK | PQNKCDDLDR | FVMVAKTVPD | DAKQLTTTIN | 
    600:
    TNAEALFRPG | PGSLHLKNGP | ESIMNSTEYP | HGGSQGQLLH | PGDHKAQAHN | 
    650:
    KALPPGLSKE | QAPDCSSSDG | SERSWMDDYD | YVHLQGKEEF | ERQQKELLEK | 
    700:
    ENIMKQNKMQ | LEHHQLSQFQ | LLEQEITKPV | ENDISKWKPS | QSLPTTNSGV | 
    750:
    SAQDRQLLCF | YYDQCETHFI | SLLNAIDALF | SCVSSAQPPR | IFVAHSKFVI | 
    800:
    LSAHKLVFIG | DTLTRQVTAQ | DIRNKVMNSS | NQLCEQLKTI | VMATKMAALH | 
    834:
    YPSTTALQEM | VHQVTDLSRN | AQLFKRSLLE | MATF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    UniGene:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human hEF1
    Cat.:
    E15036h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human hEF1
    MSDS:
    Please sign in first.
    CLIA Kit for Human hEF1
    MSDS:
    Please sign in first.
    CLIA Kit for Human hEF1
    Cat.:
    U15036h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human hEF1
    Polyclonal Antibody for Human hEF1
    Monoclonal Antibody for Human hEF1
    Monoclonal Antibody for Human hEF1
    Protein for Human hEF1
    Protein for Human hEF1

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae."
      Law S.F. , Estojak J. , Wang B. , Mysliwiec T. , Kruh G. , Golemis E.A.
      Mol. Cell. Biol.16:3327-3337(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    2. 2.
      "Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes."
      Minegishi M. , Tachibana K. , Sato T. , Iwata S. , Nojima Y. , Morimoto C.
      J. Exp. Med.184:1365-1375(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lymphoma.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Thymus.
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Lung.
    7. 7.
      "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells."
      Manie S.N. , Beck A.R.P. , Astier A. , Law S.F. , Canty T. , Hirai H. , Druker B.J. , Avraham H. , Haghayeghi N. , Sattler M. , Salgia R. , Griffin J.D. , Golemis E.A. , Freedman A.S.
      J. Biol. Chem.272:4230-4236(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INCREASED TYROSINE PHOSPHORYLATION BY LIGATION OF INTEGRIN-B1 AND BCR
    8. 8.
      "Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates."
      Tachibana K. , Urano T. , Fujita H. , Ohashi Y. , Kamiguchi K. , Iwata S. , Hirai H. , Morimoto C.
      J. Biol. Chem.272:29083-29090(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYROSINE RESIDUES BY PTK2/FAK1
    9. 9.
      "Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments."
      Law S.F. , Zhang Y.-Z. , Klein-Szanto A.J.P. , Golemis E.A.
      Mol. Cell. Biol.18:3540-3551(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    10. 10.
      "T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G."
      Ohashi Y. , Tachibana K. , Kamiguchi K. , Fujita H. , Morimoto C.
      J. Biol. Chem.273:6446-6451(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYROSINE RESIDUES UPON CD3 CROSS-LINKING
    11. 11.
      "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
      Scanlan M.J. , Gordan J.D. , Williamson B. , Stockert E. , Bander N.H. , Jongeneel C.V. , Gure A.O. , Jaeger D. , Jaeger E. , Knuth A. , Chen Y.-T. , Old L.J.
      Int. J. Cancer83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN
      tissue: Renal cell carcinoma.
    12. 12.
      "Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain."
      Law S.F. , Zhang Y.-Z. , Fashena S.J. , Toby G. , Estojak J. , Golemis E.A.
      Exp. Cell Res.252:224-235(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF CARBOXY-TERMINAL DOMAIN
    13. 13.
      "Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1."
      Zhang Y.-Z. , Lindblom T. , Chang A. , Sudol M. , Sluder A.E. , Golemis E.A.
      Gene257:33-43(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXNL4
    14. 14.
      "MICAL, a novel CasL interacting molecule, associates with vimentin."
      Suzuki T. , Nakamoto T. , Ogawa S. , Seo S. , Matsumura T. , Tachibana K. , Morimoto C. , Hirai H.
      J. Biol. Chem.277:14933-14941(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MICAL
    15. 15.
      "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."
      Salomon A.R. , Ficarro S.B. , Brill L.M. , Brinker A. , Phung Q.T. , Ericson C. , Sauer K. , Brock A. , Horn D.M. , Schultz P.G. , Peters E.C.
      Proc. Natl. Acad. Sci. U.S.A.100:443-448(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
      Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    17. 17.
      "Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation."
      Hivert V. , Pierre J. , Raingeaud J.
      Biochem. Pharmacol.78:1017-1025(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-296 AND SER-369
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Northeast structural genomics consortium target HR5554A."
      Northeast structural genomics consortium (NESG)
      Submitted (2011-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 399-563
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