CASP1 ELISA Kit for Human(Homo sapiens) | EIAab.comCASP1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CASP1(Gene name) > Human

CASP1 (Gene name),

Caspase-1 (Protein name ), CASP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CASP1(IL1BC;IL1BCE);

Protein name:

Caspase-1(CASP-1);

Alternative:

Interleukin-1 beta-converting enzyme(ICE;IL-1 beta-converting enzyme);Interleukin-1 beta convertase(IL-1BC);p45;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18.

Function:

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

404

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

404:

FPGH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000410076

String:

P29466

KEGG:

hsa:834

SMR:

P29466

UniGene:

Hs.2490

MIM:

147678

Pfam:

PF00619

Uniprot:

P29466

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ELISA Kit for Human CASP-1

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E1592d

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96T

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ELISA Kit for Human CASP-1

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E1592r

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96T

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ELISA Kit for Human CASP-1

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E1592h

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ELISA Kit for Human CASP-1

Cat.:

E1592m

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96T

ELISA Kit for Human CASP-1

Cat.:

E1592p

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96T

CLIA Kit for Human CASP-1

Cat.:

U1592d

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96T

CLIA Kit for Human CASP-1

Cat.:

U1592p

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MSDS:

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Packing:

96T

CLIA Kit for Human CASP-1

Cat.:

U1592m

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human CASP-1

Cat.:

U1592h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human CASP-1

Cat.:

U1592r

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96T

Polyclonal Antibody for Human CASP-1

Cat.:

P1592Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human CASP-1

Cat.:

P1592Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human CASP-1

Cat.:

P1592Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human CASP-1

Monoclonal Antibody for Human CASP-1

Protein for Human CASP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout"

Chang-Nam Son, So-Young Bang, Ji Hae Kim, Chan-Bum Choi, Tae-Hwan Kim, and Jae-Bum Jun

From:J Korean Med Sci

References

1.

"A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes."
Thornberry N.A. , Bull H.G. , Calaycay J.R. , Chapman K.T. , Howard A.D. , Kostura M.J. , Miller D.K. , Molineaux S.M. , Weidner J.R. , Aunins J. , Elliston K.O. , Ayala J.M. , Casano F.J. , Chin J. , Ding G.J.-F. , Egger L.A. , Gaffney E.P. , Limjuco G. , more...
Nature356:768-774(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA);PARTIAL PROTEIN SEQUENCE;ACTIVE SITE
2.

"Molecular cloning of the interleukin-1 beta converting enzyme."
Cerretti D.P. , Kozlosky C.J. , Mosley B. , Nelson N. , van Ness K. , Greenstreet T.A. , March C.J. , Kronheim S.R. , Druck T. , Cannizzaro L.A. , Huebner K. , Black R.A.
Science256:97-100(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA);PROTEIN SEQUENCE OF 120-142
3.

"Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities."
Alnemri E.S. , Fernandes-Alnemri T. , Litwack G.
J. Biol. Chem.270:4312-4317(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA; DELTA; EPSILON AND GAMMA);ALTERNATIVE SPLICING;FUNCTION
4.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
5.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-404 (ISOFORM BETA)
tissue: Testis.
7.

"Caspase-1 zeta, a new splice variant of caspase-1 gene."
Feng Q. , Li P. , Leung P.C.K. , Auersperg N.
Genomics84:587-591(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-404 (ISOFORM ALPHA);FUNCTION;MUTAGENESIS OF CYS-285;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
8.

"Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor."
Kronheim S.R. , Mumma A. , Greenstreet T. , Glackin P.J. , Van Ness K. , March C.J. , Black R.A.
Arch. Biochem. Biophys.296:698-703(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 120-142
9.

"ICEBERG: a novel inhibitor of interleukin-1beta generation."
Humke E.W. , Shriver S.K. , Starovasnik M.A. , Fairbrother W.J. , Dixit V.M.
Cell103:99-111(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARD18
10.

"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
Agostini L. , Martinon F. , Burns K. , McDermott M.F. , Hawkins P.N. , Tschopp J.
Immunity20:319-325(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COMPONENT OF THE INFLAMMASOME
11.

"INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation."
Lamkanfi M. , Denecker G. , Kalai M. , D'hondt K. , Meeus A. , Declercq W. , Saelens X. , Vandenabeele P.
J. Biol. Chem.279:51729-51738(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARD17
12.

"The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production."
Chae J.J. , Wood G. , Masters S.L. , Richard K. , Park G. , Smith B.J. , Kastner D.L.
Proc. Natl. Acad. Sci. U.S.A.103:9982-9987(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEFV
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer."
Walker N.P.C. , Talanian R.V. , Brady K.D. , Dang L.C. , Bump N.J. , Ferenz C.R. , Franklin S. , Ghayur T. , Hackett M.C. , Hammill L.D. , Herzog L. , Hugunin M. , Houy W. , Mankovich J.A. , McGuiness L. , Orlewicz E. , Paskind M. , Pratt C.A. , more...
Cell78:343-352(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS);SUBUNIT
15.

"A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)."
Rano T.A. , Timkey T. , Peterson E.P. , Rotonda J. , Nicholson D.W. , Becker J.W. , Chapman K.T. , Thornberry N.A.
Chem. Biol.4:149-155(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.73 ANGSTROMS)
16.

"Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex."
Okamoto Y. , Anan H. , Nakai E. , Morihira K. , Yonetoku Y. , Kurihara H. , Sakashita H. , Terai Y. , Takeuchi M. , Shibanuma T. , Isomura Y.
Chem. Pharm. Bull.47:11-21(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH INHIBITORS
17.

"Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding."
Romanowski M.J. , Scheer J.M. , O'Brien T. , McDowell R.S.
Structure12:1361-1371(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 120-404 OF MUTANT ALA-285

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