CASP3 ELISA Kit for Human(Homo sapiens) | EIAab.comCASP3 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CASP3(Gene name) > Human

CASP3 (Gene name),

Caspase-3 (Protein name ), CASP3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CASP3(CPP32);

Protein name:

Caspase-3(CASP-3);

Alternative:

Cysteine protease CPP32(CPP-32);Apopain;SREBP cleavage activity 1(SCA-1);Protein Yama;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.

Function:

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

277

Sequence:

50:

100:

150:

200:

250:

277:

SFDATFHAKK | QIPCIVSMLT | KELYFYH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P42574

Pfam:

PF00656

MIM:

600636

UniGene:

Hs.141125

KEGG:

hsa:836

String:

P42574

STRING:

9606.ENSP00000311032

Uniprot:

P42574

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ELISA Kit for Human CASP-3

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E0626b

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96T

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ELISA Kit for Human CASP-3

Cat.:

E0626h

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96T

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ELISA Kit for Human CASP-3

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E0626m

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96T

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ELISA Kit for Human CASP-3

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E0626r

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96T

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ELISA Kit for Human CASP-3

Cat.:

E0626p

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96T

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ELISA Kit for Human CASP-3

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ELISA Kit for Human CASP-3

Cat.:

E0626d

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Packing:

96T

CLIA Kit for Human CASP-3

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CLIA Kit for Human CASP-3

Cat.:

U0626h

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96T

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CLIA Kit for Human CASP-3

Cat.:

U0626p

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Looking for manual.

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96T

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CLIA Kit for Human CASP-3

Cat.:

U0626m

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96T

CLIA Kit for Human CASP-3

Cat.:

U0626d

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96T

CLIA Kit for Human CASP-3

Cat.:

U0626r

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96T

CLIA Kit for Human CASP-3

Cat.:

U0626b

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96T

Polyclonal Antibody for Human CASP-3

Cat.:

P0626Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human CASP-3

Cat.:

P0626Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human CASP-3

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P0626Rb-r

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Polyclonal Antibody for Human CASP-3

Monoclonal Antibody for Human CASP-3

Protein for Human CASP-3

Cat.:

R0626h

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme."
Fernandes-Alnemri T. , Litwack G. , Alnemri E.S.
J. Biol. Chem.269:30761-30764(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-190
tissue: T-cell.
2.

"Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase."
Tewari M. , Quan L.T. , O'Rourke K. , Desnoyers S. , Zeng Z. , Beidler D.R. , Poirier G.G. , Salvesen G.S. , Dixit V.M.
Cell81:801-809(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit."
Pelletier M. , Cartron P.F. , Delaval F. , Meflah K. , Vallette F.M. , Oliver L.
Biochem. Biophys. Res. Commun.316:93-99(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-190
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Tongue.
5.

NIEHS SNPs program
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
8.

"Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis."
Nicholson D.W. , Ali A. , Thornberry N.A. , Vaillancourt J.P. , Ding C.K. , Gallant M. , Gareau Y. , Griffin P.R. , Labelle M. , Lazebnik Y.A. , Munday N.A. , Raju S.M. , Smulson M.E. , Yamin T.-T. , Li V.L. , Miller D.K.
Nature376:37-43(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-46 AND 176-193;FUNCTION;VARIANT ASP-190
9.

"In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains."
Fernandes-Alnemri T. , Armstrong R.C. , Krebs J.F. , Srinivasula S.M. , Wang L. , Bullrich F. , Fritz L.C. , Trapani J.A. , Tomaselli K.J. , Litwack G. , Alnemri E.S.
Proc. Natl. Acad. Sci. U.S.A.93:7464-7469(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
10.

"Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract."
Goldberg Y.P. , Nicholson D.W. , Rasper D.M. , Kalchman M.A. , Koide H.B. , Graham R.K. , Bromm M. , Kazemi-Esfarjani P. , Thornberry N.A. , Vaillancourt J.P. , Hayden M.R.
Nat. Genet.13:442-449(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE OF HUNTINGTIN
11.

"Fas-induced caspase denitrosylation."
Mannick J.B. , Hausladen A. , Liu L. , Hess D.T. , Zeng M. , Miao Q.X. , Kane L.S. , Gow A.J. , Stamler J.S.
Science284:651-654(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-163
12.

"Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."
Bartke T. , Pohl C. , Pyrowolakis G. , Jentsch S.
Mol. Cell14:801-811(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BIRC6/BRUCE
13.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons."
Cabrera J.R. , Bouzas-Rodriguez J. , Tauszig-Delamasure S. , Mehlen P.
J. Biol. Chem.286:14628-14638(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL ADHESION
16.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis."
Rotonda J. , Nicholson D.W. , Fazil K.M. , Gallant M. , Gareau Y. , Labelle M. , Peterson E.P. , Rasper D.M. , Ruel R. , Vaillancourt J.P. , Thornberry N.A. , Becker J.W.
Nat. Struct. Biol.3:619-625(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 28-277
18.

"Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone."
Mittl P.R.E. , di Marco S. , Krebs J.F. , Bai X. , Karanewsky D.S. , Priestle J.P. , Tomaselli K.J. , Gruetter M.G.
J. Biol. Chem.272:6539-6547(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 35-173 AND 185-277
19.

"Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality."
Lee D. , Long S.A. , Adams J.L. , Chan G. , Vaidya K.S. , Francis T.A. , Kikly K. , Winkler J.D. , Sung C.-M. , Debouck C. , Richardson S. , Levy M.A. , DeWolf W.E. Jr. , Keller P.M. , Tomaszek T. , Head M.S. , Ryan M.D. , Haltiwanger R.C. , more...
J. Biol. Chem.275:16007-16014(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS)

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