Casp3 ELISA Kit for Mouse(Mus musculus) | EIAab.comCasp3 ELISA Kit for Mouse(Mus musculus)

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Casp3 (Gene name),

Caspase-3 (Protein name ), CASP3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

Casp3(Cpp32);

Protein name:

Caspase-3(CASP-3);

Alternative:

Cysteine protease CPP32(CPP-32);Apopain;Protein Yama;LICE;SREBP cleavage activity 1(SCA-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.

Function:

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

277

Sequence:

50:

100:

150:

200:

250:

277:

SLDSTFHAKK | QIPCIVSMLT | KELYFYH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P70677

KEGG:

mmu:12367

Pfam:

PF00656

UniGene:

Mm.34405

String:

P70677

Uniprot:

P70677

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ELISA Kit for Mouse CASP-3

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E0626b

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96T

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ELISA Kit for Mouse CASP-3

Cat.:

E0626h

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96T

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ELISA Kit for Mouse CASP-3

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E0626m

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ELISA Kit for Mouse CASP-3

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E0626r

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ELISA Kit for Mouse CASP-3

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E0626p

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ELISA Kit for Mouse CASP-3

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ELISA Kit for Mouse CASP-3

Cat.:

E0626d

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Packing:

96T

CLIA Kit for Mouse CASP-3

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CLIA Kit for Mouse CASP-3

Cat.:

U0626h

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96T

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CLIA Kit for Mouse CASP-3

Cat.:

U0626p

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96T

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CLIA Kit for Mouse CASP-3

Cat.:

U0626m

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96T

CLIA Kit for Mouse CASP-3

Cat.:

U0626d

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96T

CLIA Kit for Mouse CASP-3

Cat.:

U0626r

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96T

CLIA Kit for Mouse CASP-3

Cat.:

U0626b

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96T

Polyclonal Antibody for Mouse CASP-3

Cat.:

P0626Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse CASP-3

Cat.:

P0626Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse CASP-3

Cat.:

P0626Rb-r

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Polyclonal Antibody for Mouse CASP-3

Monoclonal Antibody for Mouse CASP-3

Protein for Mouse CASP-3

Cat.:

R0626h

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2/HO-1 pathway"

R S. Abdelrahman, N Abdel-Rahman.

From:Life Sciences

[2].

"Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration"

Ke Wang, Jia Xiao, Bo Peng, et al.

From:Scientific Reports

References

1.

"Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3."
Juan T.S.-C. , McNiece I.K. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Fletcher F.A.
Oncogene13:749-755(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.

"Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF."
Mukasa T. , Urase K. , Momoi M.Y. , Kimura I. , Momoi T.
Biochem. Biophys. Res. Commun.231:770-774(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Characterization of seven murine caspase family members."
van de Craen M. , Vandenabeele P. , Declercq W. , van den Brande I. , van Loo G. , Molemans F. , Schotte P. , van Criekinge W. , Beyaert R. , Fiers W.
FEBS Lett.403:61-69(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C3H/An.
4.

Fernandes-Alnemri T. , Litwack G. , Alnemri E.S.
Submitted (1997-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary gland.
6.

"Multiple pathways of apoptosis converging on the CPP32 protease."
Denis F. , Alam A. , Cohen L. , Hartgers F. , Braun M. , Martinez O. , Fortin J.-P. , Sekaly R.-P.
Submitted (1996-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 58-277
7.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
8.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
9.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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