"Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death."
Boldin M.P. , Goncharov T.M. , Goltsev Y.V. , Wallach D.
Cell85:803-815(1996) [PubMed] [Europe PMC] [Abstract]

"FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex."
Muzio M. , Chinnaiyan A.M. , Kischkel F.C. , O'Rourke K. , Shevchenko A. , Ni J. , Scaffidi C. , Bretz J.D. , Zhang M. , Gentz R. , Mann M. , Krammer P.H. , Peter M.E. , Dixit V.M.
Cell85:817-827(1996) [PubMed] [Europe PMC] [Abstract]

"In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains."
Fernandes-Alnemri T. , Armstrong R.C. , Krebs J.F. , Srinivasula S.M. , Wang L. , Bullrich F. , Fritz L.C. , Trapani J.A. , Tomaselli K.J. , Litwack G. , Alnemri E.S.
Proc. Natl. Acad. Sci. U.S.A.93:7464-7469(1996) [PubMed] [Europe PMC] [Abstract]

"FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis."
Srinivasula S.M. , Ahmad M. , Ottilie S. , Bullrich F. , Banks S. , Wang Y. , Fernandes-Alnemri T. , Croce C.M. , Litwack G. , Tomaselli K.J. , Armstrong R.C. , Alnemri E.S.
J. Biol. Chem.272:18542-18545(1997) [PubMed] [Europe PMC] [Abstract]

"Structure and chromosome localization of the human CASP8 gene."
Grenet J. , Teitz T. , Wei T. , Valentine V. , Kidd V.J.
Gene226:225-232(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."
Hadano S. , Yanagisawa Y. , Skaug J. , Fichter K. , Nasir J. , Martindale D. , Koop B.F. , Scherer S.W. , Nicholson D.W. , Rouleau G.A. , Ikeda J.-E. , Hayden M.R.
Genomics71:200-213(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade."
Himeji D. , Horiuchi T. , Tsukamoto H. , Hayashi K. , Watanabe T. , Harada M.
Blood99:4070-4078(2002) [PubMed] [Europe PMC] [Abstract]

"The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum."
Breckenridge D.G. , Nguyen M. , Kuppig S. , Reth M. , Shore G.C.
Proc. Natl. Acad. Sci. U.S.A.99:4331-4336(2002) [PubMed] [Europe PMC] [Abstract]

NIEHS SNPs program
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , Sun H. , Bradshaw-Cordum H. , Ali J. , Carter J. , Cordes M. , Harris A. , Isak A. , van Brunt A. , Nguyen C. , Du F. , Courtney L. , Kalicki J. , Ozersky P. , Abbott S. , Armstrong J. , Belter E.A. , Caruso L. , Cedroni M. , Cotton M. , Davidson T. , Desai A. , Elliott G. , Erb T. , Fronick C. , Gaige T. , Haakenson W. , Haglund K. , Holmes A. , Harkins R. , Kim K. , Kruchowski S.S. , Strong C.M. , Grewal N. , Goyea E. , Hou S. , Levy A. , Martinka S. , Mead K. , McLellan M.D. , Meyer R. , Randall-Maher J. , Tomlinson C. , Dauphin-Kohlberg S. , Kozlowicz-Reilly A. , Shah N. , Swearengen-Shahid S. , Snider J. , Strong J.T. , Thompson J. , Yoakum M. , Leonard S. , Pearman C. , Trani L. , Radionenko M. , Waligorski J.E. , Wang C. , Rock S.M. , Tin-Wollam A.-M. , Maupin R. , Latreille P. , Wendl M.C. , Yang S.-P. , Pohl C. , Wallis J.W. , Spieth J. , Bieri T.A. , Berkowicz N. , Nelson J.O. , Osborne J. , Ding L. , Meyer R. , Sabo A. , Shotland Y. , Sinha P. , Wohldmann P.E. , Cook L.L. , Hickenbotham M.T. , Eldred J. , Williams D. , Jones T.A. , She X. , Ciccarelli F.D. , Izaurralde E. , Taylor J. , Schmutz J. , Myers R.M. , Cox D.R. , Huang X. , McPherson J.D. , Mardis E.R. , Clifton S.W. , Warren W.C. , Chinwalla A.T. , Eddy S.R. , Marra M.A. , Ovcharenko I. , Furey T.S. , Miller W. , Eichler E.E. , Bork P. , Suyama M. , Torrents D. , Waterston R.H. , Wilson R.K. more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases."
Srinivasula S.M. , Ahmad M. , Fernandes-Alnemri T. , Litwack G. , Alnemri E.S.
Proc. Natl. Acad. Sci. U.S.A.93:14486-14491(1996) [PubMed] [Europe PMC] [Abstract]

"FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens."
Muzio M. , Salvesen G.S. , Dixit V.M.
J. Biol. Chem.272:2952-2956(1997) [PubMed] [Europe PMC] [Abstract]

"FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)."
Medema J.P. , Scaffidi C. , Kischkel F.C. , Shevchenko A. , Mann M. , Krammer P.H. , Peter M.E.
EMBO J.16:2794-2804(1997) [PubMed] [Europe PMC] [Abstract]

"Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes."
Horiuchi T. , Himeji D. , Tsukamoto H. , Harashima S. , Hashimura C. , Hayashi K.
Biochem. Biophys. Res. Commun.272:877-881(2000) [PubMed] [Europe PMC] [Abstract]

"p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum."
Ng F.W.H. , Nguyen M. , Kwan T. , Branton P.E. , Nicholson D.W. , Cromlish J.A. , Shore G.C.
J. Cell Biol.139:327-338(1997) [PubMed] [Europe PMC] [Abstract]

"PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis."
Condorelli G. , Vigliotta G. , Cafieri A. , Trencia A. , Andalo P. , Oriente F. , Miele C. , Caruso M. , Formisano P. , Beguinot F.
Oncogene18:4409-4415(1999) [PubMed] [Europe PMC] [Abstract]

"A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation."
Skaletskaya A. , Bartle L.M. , Chittenden T. , McCormick A.L. , Mocarski E.S. , Goldmacher V.S.
Proc. Natl. Acad. Sci. U.S.A.98:7829-7834(2001) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

"Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth."
McDonald E.R. III , El-Deiry W.S.
Proc. Natl. Acad. Sci. U.S.A.101:6170-6175(2004) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway."
Jun J.-I. , Chung C.-W. , Lee H.-J. , Pyo J.-O. , Lee K.N. , Kim N.-S. , Kim Y.S. , Yoo H.-S. , Lee T.-H. , Kim E. , Jung Y.-K.
Oncogene24:688-696(2005) [PubMed] [Europe PMC] [Abstract]

"FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies."
Milovic-Holm K. , Krieghoff E. , Jensen K. , Will H. , Hofmann T.G.
EMBO J.26:391-401(2007) [PubMed] [Europe PMC] [Abstract]

"Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity."
Matthess Y. , Raab M. , Sanhaji M. , Lavrik I.N. , Strebhardt K.
Mol. Cell. Biol.30:5726-5740(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The E.coli effector protein NleF is a caspase inhibitor."
Blasche S. , Moertl M. , Steuber H. , Siszler G. , Nisa S. , Schwarz F. , Lavrik I. , Gronewold T.M.A. , Maskos K. , Donnenberg M.S. , Ullmann D. , Uetz P. , Koegl M.
PLoS ONE0:0-0(2013)

"The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis."
Blanchard H. , Kodandapani L. , Mittl P.R.E. , Di Marco S. , Krebs J.F. , Wu J.C. , Tomaselli K.J. , Gruetter M.G.
Structure7:1125-1133(1999) [PubMed] [Europe PMC] [Abstract]

"The atomic-resolution structure of human caspase-8, a key activator of apoptosis."
Watt W. , Koeplinger K.A. , Mildner A.M. , Heinrikson R.L. , Tomasselli A.G. , Watenpaugh K.D.
Structure7:1135-1143(1999) [PubMed] [Europe PMC] [Abstract]

"Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency."
Chun H.J. , Zheng L. , Ahmad M. , Wang J. , Speirs C.K. , Siegel R.M. , Dale J.K. , Puck J. , Davis J. , Hall C.G. , Skoda-Smith S. , Atkinson T.P. , Straus S.E. , Lenardo M.J.
Nature419:395-399(2002) [PubMed] [Europe PMC] [Abstract]

"Association of a common variant of the CASP8 gene with reduced risk of breast cancer."
MacPherson G. , Healey C.S. , Teare M.D. , Balasubramanian S.P. , Reed M.W.R. , Pharoah P.D. , Ponder B.A.J. , Meuth M. , Bhattacharyya N.P. , Cox A.
J. Natl. Cancer Inst.96:1866-1869(2004) [PubMed] [Europe PMC] [Abstract]

"A common coding variant in CASP8 is associated with breast cancer risk."
The Kathleen Cunningham foundation consortium for research into familial breast cancer , Breast cancer association consortium , Cox A. , Dunning A.M. , Garcia-Closas M. , Balasubramanian S. , Reed M.W.R. , Pooley K.A. , Scollen S. , Baynes C. , Ponder B.A.J. , Chanock S. , Lissowska J. , Brinton L. , Peplonska B. , Southey M.C. , Hopper J.L. , McCredie M.R.E. , Giles G.G. , Fletcher O. , Johnson N. , dos Santos Silva I. , Gibson L. , Bojesen S.E. , Nordestgaard B.G. , Axelsson C.K. , Torres D. , Hamann U. , Justenhoven C. , Brauch H. , Chang-Claude J. , Kropp S. , Risch A. , Wang-Gohrke S. , Schuermann P. , Bogdanova N. , Doerk T. , Fagerholm R. , Aaltonen K. , Blomqvist C. , Nevanlinna H. , Seal S. , Renwick A. , Stratton M.R. , Rahman N. , Sangrajrang S. , Hughes D. , Odefrey F. , Brennan P. , Spurdle A.B. , Chenevix-Trench G. , Beesley J. , Mannermaa A. , Hartikainen J. , Kataja V. , Kosma V.M. , Couch F.J. , Olson J.E. , Goode E.L. , Broeks A. , Schmidt M.K. , Hogervorst F.B.L. , Van't Veer L.J. , Kang D. , Yoo K.-Y. , Noh D.-Y. , Ahn S.-H. , Wedren S. , Hall P. , Low Y.-L. , Liu J. , Milne R.L. , Ribas G. , Gonzalez-Neira A. , Benitez J. , Sigurdson A.J. , Stredrick D.L. , Alexander B.H. , Struewing J.P. , Pharoah P.D.P. , Easton D.F. more...
Nat. Genet.39:352-358(2007) [PubMed] [Europe PMC] [Abstract]

The Kathleen Cunningham foundation consortium for research into familial breast cancer , Breast cancer association consortium , Cox A. , Dunning A.M. , Garcia-Closas M. , Balasubramanian S. , Reed M.W.R. , Pooley K.A. , Scollen S. , Baynes C. , Ponder B.A.J. , Chanock S. , Lissowska J. , Brinton L. , Peplonska B. , Southey M.C. , Hopper J.L. , McCredie M.R.E. , Giles G.G. , Fletcher O. , Johnson N. , dos Santos Silva I. , Gibson L. , Bojesen S.E. , Nordestgaard B.G. , Axelsson C.K. , Torres D. , Hamann U. , Justenhoven C. , Brauch H. , Chang-Claude J. , Kropp S. , Risch A. , Wang-Gohrke S. , Schuermann P. , Bogdanova N. , Doerk T. , Fagerholm R. , Aaltonen K. , Blomqvist C. , Nevanlinna H. , Seal S. , Renwick A. , Stratton M.R. , Rahman N. , Sangrajrang S. , Hughes D. , Odefrey F. , Brennan P. , Spurdle A.B. , Chenevix-Trench G. , Beesley J. , Mannermaa A. , Hartikainen J. , Kataja V. , Kosma V.M. , Couch F.J. , Olson J.E. , Goode E.L. , Broeks A. , Schmidt M.K. , Hogervorst F.B.L. , Van't Veer L.J. , Kang D. , Yoo K.-Y. , Noh D.-Y. , Ahn S.-H. , Wedren S. , Hall P. , Low Y.-L. , Liu J. , Milne R.L. , Ribas G. , Gonzalez-Neira A. , Benitez J. , Sigurdson A.J. , Stredrick D.L. , Alexander B.H. , Struewing J.P. , Pharoah P.D.P. , Easton D.F. more...
Nat. Genet.39:688-688(2007)

"A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers."
Sun T. , Gao Y. , Tan W. , Ma S. , Shi Y. , Yao J. , Guo Y. , Yang M. , Zhang X. , Zhang Q. , Zeng C. , Lin D.
Nat. Genet.39:605-613(2007) [PubMed] [Europe PMC] [Abstract]

"Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma."
Li C. , Zhao H. , Hu Z. , Liu Z. , Wang L.-E. , Gershenwald J.E. , Prieto V.G. , Lee J.E. , Duvic M. , Grimm E.A. , Wei Q.
Hum. Mutat.29:1443-1451(2008) [PubMed] [Europe PMC] [Abstract]