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Index > Protein center > CASQ1(Gene name) > Human
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  • CASQ1 (Gene name),
  • Calsequestrin-1 (Protein name ),  CASQ1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CASQ1(CASQ);
    Protein name:
    Calsequestrin-1;
    Alternative:
    Calsequestrin, skeletal muscle isoform;Calmitin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin.
    Subcellular Location:
    Sarcoplasmic reticulum lumen Mitochondrion This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.
    Protein Attributes:
    Sequence length:
    396
    Sequence:
    50:
    MSATDRMGPR | AVPGLRLALL | LLLVLGTPKS | GVQGQEGLDF | PEYDGVDRVI | 
    100:
    NVNAKNYKNV | FKKYEVLALL | YHEPPEDDKA | SQRQFEMEEL | ILELAAQVLE | 
    150:
    DKGVGFGLVD | SEKDAAVAKK | LGLTEVDSMY | VFKGDEVIEY | DGEFSADTIV | 
    200:
    EFLLDVLEDP | VELIEGEREL | QAFENIEDEI | KLIGYFKSKD | SEHYKAFEDA | 
    250:
    AEEFHPYIPF | FATFDSKVAK | KLTLKLNEID | FYEAFMEEPV | TIPDKPNSEE | 
    300:
    EIVNFVEEHR | RSTLRKLKPE | SMYETWEDDM | DGIHIVAFAE | EADPDGFEFL | 
    350:
    ETLKAVAQDN | TENPDLSIIW | IDPDDFPLLV | PYWEKTFDID | LSAPQIGVVN | 
    396:
    VTDADSVWME | MDDEEDLPSA | EELEDWLEDV | LEGEINTEDD | DDDDDD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Calsequestrin-1
    Cat.:
    E15017h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Calsequestrin-1
    Cat.:
    E15017m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Calsequestrin-1
    Cat.:
    E15017r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Calsequestrin-1
    Cat.:
    E15017d
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Calsequestrin-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Calsequestrin-1
    Cat.:
    U15017r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calsequestrin-1
    Cat.:
    U15017m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calsequestrin-1
    Cat.:
    U15017h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calsequestrin-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Calsequestrin-1
    Cat.:
    U15017d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Calsequestrin-1
    Cat.:
    P15017Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calsequestrin-1
    Polyclonal Antibody for Human Calsequestrin-1
    Polyclonal Antibody for Human Calsequestrin-1
    Cat.:
    P15017Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calsequestrin-1
    Cat.:
    P15017Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Calsequestrin-1
    Monoclonal Antibody for Human Calsequestrin-1
    Monoclonal Antibody for Human Calsequestrin-1
    Monoclonal Antibody for Human Calsequestrin-1
    Monoclonal Antibody for Human Calsequestrin-1
    Protein for Human Calsequestrin-1
    Protein for Human Calsequestrin-1
    Protein for Human Calsequestrin-1
    Protein for Human Calsequestrin-1
    Protein for Human Calsequestrin-1

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    References
    1. 1.
      "Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene."
      Fujii J. , Willard H.F. , Maclennan D.H.
      Somat. Cell Mol. Genet.16:185-189(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Molecular cloning of human calmitine, a mitochondrial calcium binding protein, reveals identity with calsequestrine."
      Bataille N. , Schmitt N. , Aumercier-Maes P. , Ollivier B. , Lucas-Heron B. , Lestienne P.
      Biochem. Biophys. Res. Commun.203:1477-1482(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Skeletal muscle.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pericardium.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skeletal muscle.
    7. 7.
      "High-capacity Ca2+ binding of human skeletal calsequestrin."
      Sanchez E.J. , Lewis K.M. , Danna B.R. , Kang C.
      J. Biol. Chem.287:11592-11601(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 35-396 IN COMPLEX WITH CALCIUM;FUNCTION;SUBUNIT
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