Cbx3 ELISA Kit for Mouse(Mus musculus) | EIAab.comCbx3 ELISA Kit for Mouse(Mus musculus)

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Cbx3 (Gene name),

Chromobox protein homolog 3 (Protein name ), CBX3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cbx3;

Protein name:

Chromobox protein homolog 3;

Alternative:

M32;Heterochromatin protein 1 homolog gamma(HP1 gamma);Modifier 2 protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2 (By similarity). Interacts with LBR, INCENP, TRIM28/TIF1B and SP100. Interacts with TIF1/TIF1A. Interacts with MIS12 and DSN1 (By similarity). Can interact directly with CBX5 via the chromoshadow domain (By similarity). Interacts with SUV420H1 and SUV420H2. Interacts with POGZ.

Function:

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Subcellular Location:

Nucleus May be associated with microtubules and mitotic poles during mitosis (Potential). Associates with euchromatin and is largely excluded from constitutive heterochromatin.

Protein Attributes:

Sequence length:

183

Sequence:

50:

100:

150:

183:

VLAKEANMKC | PQIVIAFYEE | RLTWHSCPED | EAQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.280968

String:

P23198

STRING:

10090.ENSMUSP00000031862

SMR:

P23198

Pfam:

PF00385

Uniprot:

P23198

FOR

ELISA Kit for Mouse Chromobox protein homolog 3

CLIA Kit for Mouse Chromobox protein homolog 3

Polyclonal Antibody for Mouse Chromobox protein homolog 3

Monoclonal Antibody for Mouse Chromobox protein homolog 3

Protein for Mouse Chromobox protein homolog 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The gene and pseudogenes of Cbx3."
Jones D.O. , Mattei M.-G. , Horsley D. , Cowell I.G. , Singh P.B.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants."
Singh P.B. , Miller J.R. , Pearce J. , Kothary R. , Burton R.D. , Paro R. , James T.C. , Gaunt S.J.
Nucleic Acids Res.19:789-794(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-183
strain: C57BL/6.
tissue: Embryo.
3.

Lubec G. , Yang J.W. , Zigmond M.
Submitted (2007-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 160-171
tissue: Brain.
4.

"M32, a murine homologue of Drosophila heterochromatin protein 1 (HP1), localises to euchromatin within interphase nuclei and is largely excluded from constitutive heterochromatin."
Horsley D. , Hutchings A. , Butcher G.W. , Singh P.B.
Cytogenet. Cell Genet.73:308-311(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
5.

"A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors."
le Douarin B. , Nielsen A.L. , Garnier J.-M. , Ichinose H. , Jeanmougin F. , Losson R. , Chambon P.
EMBO J.15:6701-6715(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIF1A
6.

"A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin."
Schotta G. , Lachner M. , Sarma K. , Ebert A. , Sengupta R. , Reuter G. , Reinberg D. , Jenuwein T.
Genes Dev.18:1251-1262(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUV420H1 AND SUV420H2
7.

"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
8.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2; LYS-5 AND LYS-44;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
10.

"Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes."
Duong H.A. , Weitz C.J.
Nat. Struct. Mol. Biol.21:126-132(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN RHYTHMS;IDENTIFIACTION IN A LARGE PER COMPLEX

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