CCDC62 ELISA Kit for Human(Homo sapiens) | EIAab.comCCDC62 ELISA Kit for Human(Homo sapiens) | EIAab.com

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CCDC62 (Gene name),

Coiled-coil domain-containing protein 62 (Protein name ), CCD62_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

CCDC62;

Protein name:

Coiled-coil domain-containing protein 62;

Alternative:

Protein aaa;Protein TSP-NY;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter.

Function:

Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.

Subcellular Location:

Cytoplasm Nucleus Mainly nuclear.

Protein Attributes:

Sequence length:

684

Sequence:

50:

MNPPAAFLAG | RQNIGSEVEI | STIEKQRKEL | QLLIGELKDR | DKELNDMVAV |

100:

HQQQLLSWEE | DRQKVLTLEE | RCSKLEGELH | KRTEIIRSLT | KKVKALESNQ |

150:

MECQTALQKT | QLQLQEMAQK | ATHSSLLSED | LEARNETLSN | TLVELSAQVG |

200:

QLQAREQALT | TMIKLKDKDI | IEAVNHIADC | SGKFKMLEHA | LRDAKMAETC |

250:

IVKEKQDYKQ | KLKALKIEVN | KLKEDLNEKT | TENNEQREEI | IRLKQEKSCL |

300:

HDELLFTVER | EKRKDELLNI | AKSKQERTNS | ELHNLRQIYV | KQQSDLQFLN |

350:

FNVENSQELI | QMYDSKMEES | KALDSSRDMC | LSDLENNHPK | VDIKREKNQK |

400:

SLFKDQKFEA | MLVQQNRSDK | SSCDECKEKK | QQIDTVFGEK | SVITLSSIFT |

450:

KDLVEKHNLP | WSLGGKTQIE | PENKITLCKI | HTKSPKCHGT | GVQNEGKQPS |

500:

ETPTLSDEKQ | WHDVSVYLGL | TNCPSSKHPE | KLDVECQDQM | ERSEISCCQK |

550:

NEACLGESGM | CDSKCCHPSN | FIIEAPGHMS | DVEWMSIFKP | SKMQRIVRLK |

600:

SGCTCSESIC | GTQHDSPASE | LIAIQDSHSL | GSSKSALRED | ETESSSNKKN |

650:

SPTSLLIYKD | APAFNEKASI | VLPSQDDFSP | TSKLQRLLAE | SRQMVTDLEL |

684:

STLLPISHEN | LTGSATNKSE | VPEESAQKNT | FVSY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

MIM:

UniGene:

KEGG:

STRING:

9606.ENSP00000253079

Uniprot:

FOR

ELISA Kit for Human Coiled-coil domain-containing protein 62

ELISA Kit for Human Coiled-coil domain-containing protein 62

CLIA Kit for Human Coiled-coil domain-containing protein 62

CLIA Kit for Human Coiled-coil domain-containing protein 62

Polyclonal Antibody for Human Coiled-coil domain-containing protein 62

Polyclonal Antibody for Human Coiled-coil domain-containing protein 62

Monoclonal Antibody for Human Coiled-coil domain-containing protein 62

Monoclonal Antibody for Human Coiled-coil domain-containing protein 62

Protein for Human Coiled-coil domain-containing protein 62

Protein for Human Coiled-coil domain-containing protein 62

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of a novel gene highly expressed in testis."
Shan Y.X. , Yu L.
Submitted (2003-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Cerebellum.
tissue: Testis.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LYS-394
tissue: Brain.
4.

"A novel testis specific protein (TSP-NY) gene from adult testis."
Li J.M. , Chen R.H. , Chen Q. , Zhu H. , Lin M. , Zhou Z.M. , Wang L.R. , Zhou Y.D. , Cheng L.J. , Ying L.L. , Zhu H. , Sha J.H.
Submitted (2000-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 176-684 (ISOFORM 2);TISSUE SPECIFICITY
tissue: Testis.
5.

"ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells."
Chen M. , Ni J. , Zhang Y. , Muyan M. , Yeh S.
Prostate68:1273-1282(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ESR1;MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654
6.

"CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells."
Chen M. , Ni J. , Chang H.C. , Lin C.Y. , Muyan M. , Yeh S.
Carcinogenesis30:841-850(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ESR2;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654
7.

"Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity."
Domae S. , Nakamura Y. , Nakamura Y. , Uenaka A. , Wada H. , Nakata M. , Oka M. , Kishimoto K. , Tsukamoto G. , Yoshihama Y. , Matsuoka J. , Gochi A. , Kohno S. , Saika T. , Sasaki A. , Nakayama E. , Ono T.
Int. J. Cancer124:2347-2352(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-31

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